East Nusa Tenggara (NTT) is one of the highlights in Indonesian development programs, along with other areas in eastern Indonesia. Some indicators show that NTT is lagging behind other states compared to others, although it has abundant natural resources. Supported by extensive waters, coastal areas, and strategic geographical conditions, NTT's marine sector should be the dominant sector that sustains the economy of NTT. Exploiting these opportunities aligned with the concept of the Blue Economy, which turns the maritime sector into a key economic development basis, in addition to the preservation of nature. Accordingly, the concept of a blue economy is very suitable to be developed in NTT. This study analyzed the topic using a combination of qualitative and quantitative methods, namely LQ analysis, AHP analysis, literature review, and interview. The results indicate that the concept of a blue economy significantly assists the economic development of NTT to create a sustainable economic development.