Measurement of TSH Receptor Antibody in Pregnant Women with Graves’ Disease Predicts Thyroid Function of the Newborn

Sasaki, Nozomu; Ohnishi, Takashi; Sato, Hírokazu; Wataki, Kunio; Tamaru, Kiyoe; T, Tsuyusaki; Inomata, Hiroaki; Miyaji, T; Niimi, Hiroo

doi:10.1297/cpe.7.111

Cited by 1 publication

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“…Since the maternal and transplacental neonatal antibodies against TSH receptors are significantly correlated [28], the reason of early decrease of neonatal TSBAb might be that the elevated titer of maternal TSBAb was not so severe. Because the administration of L-T 4 was not needed permanently, we finally considered that primary hypothyroidism in our neonate was caused by the transplacental passage of maternal TSBAb, not by a defect in the biosynthesis of thyroid hormone.…”

Section: Case Reportmentioning

confidence: 99%

Fetal Goitrous Hypothyroidism due to Maternal Thyroid Stimulation-Blocking Antibody: A Case Report

Ohira

Miyake²,

Kobara³

et al. 2010

Fetal Diagn Ther

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Most fetal goitrous hypothyroidisms are reportedly caused by the maternal use of an antithyroid drug or fetal dyshormonogenesis. However, fetal goitrous hypothyroidism due to the transplacental passage of maternal thyroid stimulation-blocking antibody (TSBAb) is extremely rare. A woman at 28 weeks of gestation was found to have a fetal goiter by ultrasonography. Because the maternal serum showed hypothyroidism with an elevated titer of TSBAb, levothyroxine sodium was administered. The patient delivered a male infant, 3,412 g, with a goiter at term. Umbilical blood revealed primary hypothyroidism with increased TSBAb, and the infant was given levothyroxine sodium. After a month, neonatal thyroid function and TSBAb levels became normal. Attention should be paid to possible fetal hypothyroidism when a fetal goiter is observed to avoid impaired mental development of the neonate.

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Section: Case Reportmentioning

confidence: 99%