Measurement of trabeculated left ventricular mass using cardiac magnetic resonance imaging in the diagnosis of left ventricular non-compaction

Jacquier, Alexis; Thuny, Franck; Jop, Bertrand; Giorgi, Roch; Cohen, F.; Gaubert, Jean-Yves; Vidal, Vincent; Bartoli, Jean Michel; Habib, Gilbert; Moulin, G.

doi:10.1093/eurheartj/ehp595

Cited by 458 publications

(358 citation statements)

References 19 publications

Supporting

Mentioning

301

Contrasting

Unclassified

Order By: Relevance

“…All ll studies in pediatric patients with NCM have shown higher prevalence of familiar cases, facial dysmorphisms and Wolf Parkinson White syndrome compared with adults in whom the usual findings are secondary arrhythmias, [18][19][20][21][22] as well as more cardiovascular symptoms. NCM may be asymptomatic or it can present with symptoms of severe left ventricular dysfunction, arrhythmias and embolic events [23][24][25]. In a small caseseries, mean time to onset of symptoms after diagnosis was 3 years and 6 months [5].…”

Section: Discussionmentioning

confidence: 99%

“…Color Doppler can identify flow among the intertrabecular recesses [23]. For MRI the diagnostic criterionis that of Petersen et al This is the ratio between the compact and noncompact portion of the myocardium greater than 2.3 measured at the end ofdiastole, which is usually bigger than 2,3 [25,26].…”

Section: Discussionmentioning

confidence: 99%

“…Also used are Jaquer's et al [25] criteria which consider the trabecular left ventricular mass, which should be greater than 20% of the overall mass of the same ventricle measured at end of diastole. Other diagnostic aids are CT and ventriculography.…”

Section: Discussionmentioning

confidence: 99%

“…Arrhythmias are treated with beta blockers, calcium channel blockers or amiodarone, as appropriate. Carvedilol has demonstrated beneficial effects in left ventricular function [25]. For the prevention of embolic complications several authors recommend anticoagulation in all the patients.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Non-Compacted Myocardium (Ncm) with Pre-Exitacion Syndrome: Report of Two Cases

Mosquera¹

2015

JCCR

View full text Add to dashboard Cite

Nineteen (19) years old Colombian male,who consulted the cardiology service, for a 7 years history of Grade II NHYA dyspnea, syncope in the last 4 years, and more recently intermittent chest palpitations, accompanied by atypical chest pain.The patient underwent surgical closure of patent arterious ductus at 10 years of age, and ablation of a right septal posterior pathway associated with supraventricular tachycardia (SVT) with. WPW syndrome, at 16 years of age. There is a history of allergy to dipyrone and metoclopropamide. Physical examination and EKGOn admission blood pressure was 110/60mm/Hg, heart rate 136 beats per minuteand respiratory rate 18 breaths per minute. No other abnormalities were found. FBC, renal function tests, blood glucose, coagulation and electrolytes were within normal limits. Natriuretic peptide was 154 pg/ml (normal <100 pg/ml). The EKG documented atrial fibrillation witha high ventricular response to 140 beats per minute. Diagnosis and managementA transesophageal echocardiogram ruledout intracavitary thrombi. The left chambers were dilated with slow flow in the left atrium. The walls of the left ventricle had normal thickness with severe overall decreased contractility, and the endocardium was thickened and hyper refringent at the middle and basal thirds. The apex was also thickened with increased number of trabeculae and obliteration of the cavity. Left ventricular function was 20-25%. A a bicuspid aortic valve,with mildregurgitation was found, the right atrium was severely dilated and the right ventricle was normal in size but its walls were thickened and severely hypo kinetic.Pulmonary arterysystolic pressure was 46 mmHg, with moderate tricuspid regurgitation. No pericardial effusion was seen, and the aorta was normal with atrial septal integrity. Heart MRI revealed an altered left ventricular morphological pattern characterized by the presence of multiple trabeculae forming a reticular pattern, especially affecting the distal half of the ventricle. The interventricular septum bulged from left to right, and there was mild hypokinesia of the middle third of the interventricular septum, mainly towards itsanterior half. No areas of abnormal uptakewere found in the ventricular walls. There was no pericardial effusion and no infiltration of the myocardium or areas of scarring. The findings were compatible with non-compacted myocardium (Figure 1 & 2). An electrophysiological study ruled out the presence of an accessory hidden pathway. Due to the presence of an atypical slow atrial flutter fast degenerating into atrial fibrillation, no ablation was performed. AbstractNon-compaction cardiomyopathy (spongiform cardiomyopathy) is a primary disorder of the ventricular muscle of unknown cause, which can occur at any age, often between 20 to 40 years of age. It affects mainly men, and can be asymptomatic or present with symptoms of heart failure, arrhythmias or embolic events. Color Doppler echocardiography and nuclear magnetic resonance (cMRI) are the most commonly used diagnostic methods. No s...

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Non-Compacted Myocardium (Ncm) with Pre-Exitacion Syndrome: Report of Two Cases

Mosquera¹

2015

JCCR

View full text Add to dashboard Cite

show abstract

“…Cardiac MRI is an emerging modality in the diagnosis of LVNC carrying the advantage of high spatial resolution and image quality [73][74][75] (Figure 3). Three diagnostic criteria have been developed by Petersen et al, Jacquier et al, and Stacey et al (Table 2).…”

Section: Diagnosismentioning

confidence: 99%

Left Ventricular Non-Compaction: Current Controversy and New Insights

E¹

2015

J Genet Syndr Gene Ther

View full text Add to dashboard Cite

Left ventricular non-compaction is an increasingly recognized familial cardiomyopathy characterized morphologically by deep myocardial trabeculations and a highly variable, but potentially aggressive clinical course leading to cardiac death or cardiac transplantation. Great controversy exists regarding the pathophysiology, diagnostic approach, clinical characteristics, and management of the condition. To date, there are no universally accepted precise diagnostic criteria or management guidelines. Recent clinical studies and basic science research have significantly added to our understanding of LVNC in all of these aspects. This article reviews the literature to date on LVNC and addresses current controversies surrounding the pathophysiology, diagnosis, clinical features, and management.

show abstract