Measurement of total respiratory impedance in infants by the forced oscillation technique

Desager, K N; Buhr, W.; Willemen, Marc; Bever, Hugo P. Van; Backer, Wilfried De; Vermeire, P.; Landser, F. J.

doi:10.1152/jappl.1991.71.2.770

Cited by 50 publications

(28 citation statements)

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“…Recommendations have been developed by an American Thoracic Society/European Respiratory Society Working Party [115] and the specific preparation measures for the FOT and details of the methodology have been described by DESAGER et al [116]. The large values of Zrs in infants impose particularly strict performance requirements concerning the measurement set-up and the calibration procedure [117][118][119].…”

Section: Forced Oscillation Technique In Infancymentioning

confidence: 99%

The forced oscillation technique in clinical practice: methodology, recommendations and future developments

Oostveen¹,

MacLeod²,

Lorino³

et al. 2003

European Respiratory Journal

1,083

1,120

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The forced oscillation technique (FOT) is a noninvasive method with which to measure respiratory mechanics. FOT employs small-amplitude pressure oscillations superimposed on the normal breathing and therefore has the advantage over conventional lung function techniques that it does not require the performance of respiratory manoeuvres.The present European Respiratory Society Task Force Report describes the basic principle of the technique and gives guidelines for the application and interpretation of FOT as a routine lung function test in the clinical setting, for both adult and paediatric populations.FOT data, especially those measured at the lower frequencies, are sensitive to airway obstruction, but do not discriminate between obstructive and restrictive lung disorders. There is no consensus regarding the sensitivity of FOT for bronchodilation testing in adults. Values of respiratory resistance have proved sensitive to bronchodilation in children, although the reported cutoff levels remain to be confirmed in future studies.Forced oscillation technique is a reliable method in the assessment of bronchial hyperresponsiveness in adults and children. Moreover, in contrast with spirometry where a deep inspiration is needed, forced oscillation technique does not modify the airway smooth muscle tone. Forced oscillation technique has been shown to be as sensitive as spirometry in detecting impairments of lung function due to smoking or exposure to occupational hazards. Together with the minimal requirement for the subject9s cooperation, this makes forced oscillation technique an ideal lung function test for epidemiological and field studies. Novel applications of forced oscillation technique in the clinical setting include the monitoring of respiratory mechanics during mechanical ventilation and sleep.

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Section: Forced Oscillation Technique In Infancymentioning

confidence: 99%

The forced oscillation technique in clinical practice: methodology, recommendations and future developments

Oostveen¹,

MacLeod²,

Lorino³

et al. 2003

European Respiratory Journal

1,083

1,120

View full text Add to dashboard Cite

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“…This is especially the case in young children or in adult populations where spirometry is not feasible, as the FOT does not require a learned manoeuvre [1][2][3][4][5].…”

mentioning

confidence: 99%

Airway resistance variability and response to bronchodilator in children with asthma

Lall¹,

Cheng²,

Hernández³

et al. 2007

European Respiratory Journal

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Variability of airway function is a feature of asthma, spanning timescales from months to seconds. Short-term variation in airway resistance (Rrs) is elevated in asthma and is thought to be due to increased variation in the contractile activation of airway smooth muscle. If true, then variation in Rrs should decrease in response to bronchodilators, but this has not been investigated.Using the forced oscillation technique, Rrs and the variation in Rrs from 4-34 Hz were measured in 39 children with well-controlled mild-to-moderate asthma and 31 healthy controls (7-13 yrs) before and after an inhaled bronchodilator (200 mg salbutamol) or placebo.In agreement with other findings, baseline Rrs at all frequencies and the SD of Rrs (Rrs SD) below 14 Hz were found to be elevated in asthma while neither forced expiratory volume in one second nor the mean forced expiratory flow between 25 and 75% of forced vital capacity were different compared with controls. The present authors found that Rrs SD changed the most of any measurement in asthma, and this was the only measurement that changed significantly more in children with asthma following bronchodilator administration.The present results show that like airway narrowing, short-term airway variability of resistance may be a characteristic feature of asthma that may be useful for monitoring response to therapy.

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“…min -1 ). Previous studies have shown that the lower frequency ranges have proven very informative in adults [2, 17±19], children [20] and infants [6,8,15]. Furthermore, especially in preterm newborns the breathing pattern is often irregular and disturbed by various physiological occurrences (sighs, swallows, cardiac activities) and technical artefacts (drift, noise, air leaks) [21].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, in newborns the lower cut-off frequency of the respiratory signals may be additionally increased. DESAGER et al [6] reported measuring problems of Zrs(jv) at low frequencies in infants due to spontaneous breathing. They found a high coefficient of variation and a low coherence at f <16 Hz.…”

Section: Discussionmentioning

confidence: 99%

In vitro investigations of jet-pulses for the measurement of respiratory impedance in newborns

Schmidt¹,

Foitzik²,

Hochmuth³

et al. 1999

Eur Respir J

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The aim of this in vitro study was to investigate the measuring range and accuracy of a miniaturized equipment for respiratory impedance (Zrs) measurements in newborns using jet-pulses.Brief flow pulses (peak flow=16 L . min -1 , width=10 ms) were generated by a jet-generator consisting of a solenoid valve and an injector, situated between pneumotachographandoutflowresistance.Seriallyarrangedresistance-inertance-compliance(R-I-C) lung models (RM=1.) were used to measure the real and imaginary part of Zrs between 4 and 50 Hz and to determine R, C and I by means of the method of least squares.The median errors for R, C and I were -0.1 kPa . 19%) in mechanically ventilated models. During spontaneous breathing the influence of the breathing flow on Zrs was neg-ligible. The equipment did not show any nonlinearity when different pulse amplitudes were used (V'max=13±22 L . min -1 ). The investigations have shown that jet-pulses allow reliable measurements of respiratory impedance and have the potential to provide valuable information about lung mechanics in spontaneously breathing and mechanically ventilated newborns. The developed measuring head has a low apparatus dead space, is easy to disinfect, has standard connections and can be used as the T-piece in a ventilator circuit.

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Measurement of total respiratory impedance in infants by the forced oscillation technique

Cited by 50 publications

References 0 publications

The forced oscillation technique in clinical practice: methodology, recommendations and future developments

The forced oscillation technique in clinical practice: methodology, recommendations and future developments

Airway resistance variability and response to bronchodilator in children with asthma

In vitro investigations of jet-pulses for the measurement of respiratory impedance in newborns

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