Abstract:To understand the current situation of internal radiation exposure in the population around the Chernobyl Nuclear Power Plant (CNPP), we examined the 137Cs body burden in six residents of Belarus, Ukraine and Russia in 2002 and 2004 using the whole-body counter (WBC) at Nagasaki University (Japan). The data were compared with those of our previous study performed in 1993-1994 using the same method. In 2002 and 2004, peaks of 137Cs were detected in two residents from Gomel, which was heavily contaminated by the… Show more
“…To preserve the longitudinal comparisons of the samples, we only used individual whole-body count of 137 Cs for comparison of exposure measures. The body burden of 137 Cs was adjusted for weight (kg) [27]. Because of known variations with season of quantification [28,29], we also took the month of measurement into account.…”
BackgroundAfter the Chernobyl nuclear incident in 1986, children in the Narodichesky region, located 80 km west of the Chernobyl Power Plant, were exposed to 137Cesium (137Cs). Little is known about the effects of chronic low-level radiation on humoral immune responses in children residing in contaminated areas.MethodsIn four different approaches we investigated the effect of residential 137Cs exposure on immunoglobulins A, G, M, and specific immunoglobulin E in children. In a dynamic cohort (1993–1998) we included 617 children providing 2,407 repeated measurements; 421 and 523 children in two cross-sectional samples (1997–1998 and 2008–2010, respectively); and 25 participants in a small longitudinal cohort (1997–2010). All medical exams, blood collections, and analyses were conducted by the same team. We used mixed linear models to analyze repeated measurements in cohorts and general linear regression models for cross-sectional studies.ResultsResidential soil contamination in 2008 was highly correlated with the individual body burden of 137Cs. Serum IgG and IgM concentrations increased between 1993 and 1998. Children with higher 137Cs soil exposure had lower serum IgG levels, which, however, increased in the small cohort assessed between 1997 and 2010. Children within the fourth quintile of 137Cs soil exposure (266–310 kBq/m2) had higher IgM serum concentrations between 1993 and 1998 but these declined between 1997 and 2010. IgA remained stable with median 137Cs exposures related to higher IgA levels, which was corroborated in the cross-sectional study of 2008–2010. Specific IgE against indoor allergens was detected less often in children with higher 137Cs exposure.ConclusionsOur findings show radiation-related alterations of immunoglobulins which by themselves do not constitute adverse health effects. Further investigations are necessary to understand how these changes affect health status.
“…To preserve the longitudinal comparisons of the samples, we only used individual whole-body count of 137 Cs for comparison of exposure measures. The body burden of 137 Cs was adjusted for weight (kg) [27]. Because of known variations with season of quantification [28,29], we also took the month of measurement into account.…”
BackgroundAfter the Chernobyl nuclear incident in 1986, children in the Narodichesky region, located 80 km west of the Chernobyl Power Plant, were exposed to 137Cesium (137Cs). Little is known about the effects of chronic low-level radiation on humoral immune responses in children residing in contaminated areas.MethodsIn four different approaches we investigated the effect of residential 137Cs exposure on immunoglobulins A, G, M, and specific immunoglobulin E in children. In a dynamic cohort (1993–1998) we included 617 children providing 2,407 repeated measurements; 421 and 523 children in two cross-sectional samples (1997–1998 and 2008–2010, respectively); and 25 participants in a small longitudinal cohort (1997–2010). All medical exams, blood collections, and analyses were conducted by the same team. We used mixed linear models to analyze repeated measurements in cohorts and general linear regression models for cross-sectional studies.ResultsResidential soil contamination in 2008 was highly correlated with the individual body burden of 137Cs. Serum IgG and IgM concentrations increased between 1993 and 1998. Children with higher 137Cs soil exposure had lower serum IgG levels, which, however, increased in the small cohort assessed between 1997 and 2010. Children within the fourth quintile of 137Cs soil exposure (266–310 kBq/m2) had higher IgM serum concentrations between 1993 and 1998 but these declined between 1997 and 2010. IgA remained stable with median 137Cs exposures related to higher IgA levels, which was corroborated in the cross-sectional study of 2008–2010. Specific IgE against indoor allergens was detected less often in children with higher 137Cs exposure.ConclusionsOur findings show radiation-related alterations of immunoglobulins which by themselves do not constitute adverse health effects. Further investigations are necessary to understand how these changes affect health status.
“…We estimated the annual exposure dose, based on the effective dose coefficient 2.5*10 -3 mSv/year per Bq/kg (1) . We also calculated the 50-year exposure doses commitment with the 137 Cs peak, according to the formula (3.821* 137 Cs concentration (Bq)*70/4,000,000/body weight (kg)) developed by Shimasaki and Okumura, based on the physiological half-life of 137 Cs (9) . Data are expressed as median (25 th -75 th percentile) or median (minimum-maximum).…”
To determine the current risk of internal radiation exposure after the Chernobyl accident, the (137)Cs body burden of the inhabitants of Bryansk Oblast, Russian Federation was evaluated, from 1998 to 2008. The study population is composed of 84 666 people who visited Bryansk No. 2 Hospital. A whole-body counter was used for measurement of (137)Cs body burden. (137)Cs concentration was significantly higher in the late period during the study and showed seasonal variation, suggesting that inhabitants may have consumed contaminated forest products. However, people with high annual exposure doses were quite rare during all years of the study. In conclusion, although internal radiation exposure from (137)Cs continues to this day in Bryansk Oblast, the annual exposure dose is low in almost all inhabitants. Because of the long half-life of (137)Cs, the long-term follow-up is necessary to monitor the health status and relieve the anxiety of the inhabitants around Chernobyl.
“…Останнім часом досить дискусійним є питання про статус населення, котре проживає на територіях, забруднених радіонуклідами внаслідок аварії на ЧАЕС. З одного боку, основний фактор забруднення цих територій -довгоживучий радіонуклід 137 Cs, період піврозпаду якого -30 років [1,2]. Таким чином, з 1986 р. пройшов час, достатній для істотного зниження радіаційного навантаження на стан здоров'я мешканців IV радіаційної зони -території посиленого радіоекологічного контролю.…”
Вивчали особливості показників імунної системи у мешканців територій, забруднених радіонуклідами, за умов додаткового психоемоційного навантаження. Обстежено 150 осіб з відносно екологічно чистих територій (контрольна група) і 200 осіб з територій посиленого радіоекологічного контролю. Всі обстежені-студенти Черкаського національного університету віком від 18 до 24 років. Роль додаткового фактора психоемоційного навантаження відіграла зимова екзаменаційна сесія. Встановлено, що в міжсесійний період спостерігалися перерозподіл лейкограми на користь гранулоцитарних фракцій, а також зниження відносної і абсолютної кількості лімфоцитів, що експресують антигени CD3, CD5, CD4, CD16, зниження імунорегуляторного індексу CD4 + /CD8 + і підвищення концентрації сироваткового імуноглобуліну G. Психоемоційне навантаження посилювало виявлені тенденції, внаслідок чого значень, нижчих від гомеостатичної норми, сягали відносна (23,41±1,01%) і абсолютна кількість (0,28±0,02•10 9 /л) Т-лімфоцитів з фенотипом CD4 + та імунорегуляторний індекс (1,04±0,03). Для цих же показників спостерігався найдовший період відновлення. Ключові слова: радіаційне забруднення; стрес; кортизол; імуносупресія; відновний період.
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