Measurement of the ultrasonic intima-media complex thickness in normal subjects

Veller, Martin; Fisher, Charles; Nicolaides, Andrew; Renton, Sophie; Geroulakos, George; Stafford, Nicolas J.; Sarker, Ajanta; Gabi, Szendro; Belcaro, Gianni

doi:10.1016/0741-5214(93)90116-4

Cited by 174 publications

(95 citation statements)

References 13 publications

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“…High-resolution B-mode ultrasonography is a non-invasive technique used to measure the intima-media thickness (IMT) of the arterial wall [24][25][26]. It is a validated surrogate marker of atherosclerosis [27].…”

Section: Introductionmentioning

confidence: 99%

Increased augmentation of central blood pressure is associated with increases in carotid intima–media thickness in type 2 diabetic patients

et al. 2005

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Aims/hypothesis: Type 2 diabetes is associated with a two-to seven-fold increase in cardiovascular morbidity and mortality. The aim of this study was to determine the relationships between intima-media thickness (IMT), an established marker of atherosclerosis, large artery function and other determinants of cardiovascular risk in type 2 diabetic patients. Methods: We studied 228 type 2 diabetic patients (75 women, aged 62±2 years [mean± SEM]). Carotid IMT was bilaterally measured using ultrasound technology. Applanation tonometry and pulse wave analysis were used to measure aortic systolic and diastolic blood pressures, central pressure augmentation (AG) and the augmentation index (AIx), a measure of systemic arterial stiffness. Conventional cardiovascular risk factors (lipids, HbA 1 c, smoking and diabetes duration) were also assessed. Results: Women had higher AG and AIx (p<0.0001), despite comparable systolic BP and heart rate in women and men. In women, AG (r=0.39, p<0.001), age (r=0.32, p<0.01), brachial systolic BP (r=0.34, p< 0.01) and aortic systolic BP (r=0.34, p<0.01) correlated with IMT. In men, age (r=0.41, p<0.001), diabetes duration (r=0.25, p<0.01), AG (r=0.22, p<0.01), aortic systolic BP (r=0.21, p<0.01), brachial systolic BP (r=0.21, p<0.01) and body weight (r=0.16, p<0.05) correlated with IMT. In multiple linear regression analyses, AG and aortic systolic BP, but not brachial systolic BP, were age-independent determinants of IMT in men and women. In all patients, increased AG (adjusted for sex, age and heart rate) correlated with longer duration of diabetes, urinary albumin excretion and IMT. Conclusions/interpretation: Measures of central systolic pressure correlate with carotid IMT, independently of age and other risk markers.

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Section: Introductionmentioning

confidence: 99%

Increased augmentation of central blood pressure is associated with increases in carotid intima–media thickness in type 2 diabetic patients

et al. 2005

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“…IMT is a main indicator of the early lesions of the arterial wall [16], and is also a risk factor for future cerebral vascular events [17]. Although previous study has reported a significant correlation between IMT and plaque formation rate [18], however, study on the correlation between the degree of CAA stenosis, the echogenicity of the plaque and the IMT is rare. In the present study, we found that relationship between the degree of stenosis, the nature of the plaques and the the IMT were all correlated.…”

Section: Discussionmentioning

confidence: 86%

Relation between Carotid Stenosis Severity, Plaque Echogenicity Characteristics and IMT Assessed by Ultrasound in the Community Population of Southern China

Liao¹,

Hong²,

Wang³

2015

OALib

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Carotid artery atherosclerosis (CAA) is one of the major high-risk mechanisms of stroke. Relationship between IMT, carotid plaque echogenicity and carotid stenosis assessed by ultrasound has not been systemically studied, especially in subjects with mild to moderate carotid stenosis. In this study we measured these 3 different ultrasound-derived quantitative traits concurrently in the community population of southern China and compared their associations. We found that IMTmean in the non-stenosis group (0%), <30% group and ≥30% group were 0.72 ± 0.11 mm, 0.85 ± 0.13 mm, 0.90 ± 0.17 mm respectively. IMT mean of the <30% group and ≥30% group were higher than that of 0% group (P < 0.01), ≥30% group was higher than <30% group (P < 0.01). IMT mean in the no-plaque group, hyperechoic group and hypoechoic group were 0.75 ± 0.13 mm, 0.87 ± 0.17 mm, 0.84 ± 0.15 mm respectively. IMT mean of the hyperechoic group and the hypoechoic group was higher than that of the no-plaque group (P < 0.01), IMT mean of the hypoechoic group was lower than that of the hyperechoic group, though with no statistic significance (P = 0.58). The proportion of hyperechoic or hypoechoic plaque in the <30% group was higher than that in the non-stenosis group (P < 0.01), as well as proportion of hypoechoic plaque in the ≥30% group was higher than that in the <30% group (P < 0.01). Our study indicated that there is definite correlation between stenosis severity, plaque echogenicity characteristics and IMT in evaluation the extent of CAA with ultrasound. The result suggests that the 3 different ultrasound-derived quantitative traits, are a progressing process, and this process increases the risk of stroke, thus medical treatment especially stabilizing the plaques is necessary.

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“…However, this relationship is not a very strong relationship possibly due to relatively younger mean age of the cases (45.94±9.04 years) (r=0.386). Increased carotid artery IMT is the early sign of atherosclerotic diseases (34). In our study, IMT measurement of more than 0.9 mm considered to be atherosclerotic was determined in only 2% (2 patient) of the cases.…”

Section: Discussionmentioning

confidence: 93%

The relationship between mean platelet volume and flow mediated dilatation and intima media thickness of carotid artery in patients with essantial hypertension

Erden¹

2017

J Turgut Ozal Med Cent

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Aim: Hypertension is an important risk factor in the development of atherosclerosis . Our aim in this study was to determine the relationship between mean platelet volume (MPV) which is a risk factor of atherosclerosis and intima media thickness (IMT) of carotid artery and flow-mediated dilatation (FMD), markers of atherosclerosis, in patients with essential hypertension. Material and Methods: 50 adults, applying to Kirikkale University Medical Faculty department of internal medicine, (outpatient) clinics, diagnosed as hypertensive for the first time Were included in the study. Their ages ranaed between 18 to 80 nd. We included 50 healthy participants to the study as control group. Carotid Artery Doppler ultrasonography and flow-mediated dilatation (FMD) with the brachial artery ultrasonographic measurment technique was performed by using Ecography (General Electric Vivid S5) and 12 L probe for each patient. Results: In this study statistically significant relationship was found between IMT and age. In the hypertensive group, IMT of carotid artery was found to be higher in comparison with the control group. However this result was'nt statistically significant. There were no statistically significant difference in MPV, FMD or IMT hypertensive and control groups. Small number of the participants and relatively younger mean age of the groups may lead to this result and can be considered as a limitation of this study. Conclusion: Determining atherosclerosis earlier in patients with essential hypertension may provide development of new treatment modalities. In order to conclude more confidentIy extended studies with larger patient groups are needed.

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Measurement of the ultrasonic intima-media complex thickness in normal subjects

Cited by 174 publications

References 13 publications

Increased augmentation of central blood pressure is associated with increases in carotid intima–media thickness in type 2 diabetic patients

Increased augmentation of central blood pressure is associated with increases in carotid intima–media thickness in type 2 diabetic patients

Relation between Carotid Stenosis Severity, Plaque Echogenicity Characteristics and IMT Assessed by Ultrasound in the Community Population of Southern China

The relationship between mean platelet volume and flow mediated dilatation and intima media thickness of carotid artery in patients with essantial hypertension

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