Measurement of the orbitofrontal cortex: a validation study of a new method

Lacerda, Acioly L.T.; Hardan, Antonio Y.; Yorbık, Özgür; Keshavan, Matcheri S.

doi:10.1016/s1053-8119(03)00137-x

Cited by 46 publications

(37 citation statements)

References 41 publications

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“…Proportional changes of this kind could pose a problem in comparing studies using different methodologies, especially those concerned with structural-behavioral relationships (e.g., Van Petten, 2004, Allen et al, 2006, regarding the hippocampus and memory). Even with neuroanatomical criteria and volumetric methodology carefully defined, morphometric studies of smaller structures such as the hippocampus (Pedraza et al, 2004) or the orbitofrontal cortex (Lacerda et al, 2003) often produce discrepant results. One thing to be concerned about is that the introduction and wide-spread adoption (because of ease of use) of an automated, spatial-transformation-based volumetric method for smaller anatomical structures could have a disproportionate influence on the field as a whole.…”

Section: Comparing Transformation Methodsmentioning

confidence: 99%

Effects of spatial transformation on regional brain volume estimates

et al. 2008

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Spatial transformation of MR brain images is a standard tool used in automated anatomical parcellation and other quantitative and qualitative methods to assess brain tissue volume, composition, and distribution. Despite widespread use, the quantitative effects of spatial transformation on regional brain volume estimates have been little studied. We report on the effects of transformation on regional brain volumes of 38 (17M, 21F) manually parcellated brains. After tracing in native space, regions of interest were transformed using a classic piecewise linear Talairach transformation (Tal) or a nonlinear registration (AIR 5 th order nonlinear algorithm, 158 parameters) to one of three Talairach-based templates: 1) Tal50, constructed from 50 Talairach-transformed normal brains, 2) the MNI 305 atlas, 3) IA38, constructed from MNI305-transformed scans of the 38 subjects used in this study. Native volumes were compared to the transformed volumes. We found that: 1) significant group level differences can be obtained in transformed data sets that are in the opposite direction of effects obtained in native space; 2) the effects of transformation are heterogeneous across brain regions, even after covarying for total brain volume and age; 3) volumetric intra-class correlations between native and transformed brains differ by registration method and template choice, region, and tissue type; and 4) transformed brains produced hippocampus and corpus callosum volume proportions that were significantly different from those obtained in native space. Our results suggest that region-based volumetric differences uncovered by spatial-transformation-based methods should be replicated in native-space brains, and that metaanalyses should take into account whether volumes are determined using spatially-transformed images and/or specific automated methods.

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Section: Comparing Transformation Methodsmentioning

confidence: 99%

Effects of spatial transformation on regional brain volume estimates

et al. 2008

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“…12,13 A detailed description of the geometrical method utilized to measure the orbitofrontal cortex is presented elsewhere. 20 We started tracing the amygdala on the coronal slice where the mammillary bodies first appeared. The superior and lateral borders were distinguished by the temporal lobe white matter.…”

Section: Regions-of-interestmentioning

confidence: 99%

Fronto-limbic brain structures in suicidal and non-suicidal female patients with major depressive disorder

et al. 2006

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Our knowledge about the neurobiology of suicide is limited. It has been proposed that suicidal behavior generally requires biological abnormalities concomitant with the personality trait of impulsivity/aggression, besides an acute psychiatric illness or psychosocial stressor. We investigated fronto-limbic anatomical brain abnormalities in suicidal and non-suicidal adult female patients with unipolar depression. Our sample consisted of seven suicidal unipolar patients, 10 non-suicidal unipolar patients and 17 healthy female comparison subjects. The criterion for suicidality was one or more documented lifetime suicide attempts. A 1.5T GE Signa Imaging System running version Signa 5.4.3 software was used to acquire the magnetic resonance imaging images. All anatomical structures were measured blindly, with the subjects' identities and group assignments masked. We used analysis of covariance with age and intracranial volume as covariates and the Tukey-Kramer procedure to compare suicidal patients, non-suicidal patients and healthy comparison subjects. Suicidal patients had smaller right and left orbitofrontal cortex gray matter volumes compared with healthy comparison subjects. Suicidal patients had larger right amygdala volumes than non-suicidal patients. Abnormalities in the orbitofrontal cortex and amygdala in suicidal patients may impair decision-making and predispose these patients to act more impulsively and to attempt suicide.

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“…Detailed descriptions of the method utilized to measure the OFC and TBV have previously been published (Hardan et al, in press;Lacerda et al, 2003;Magnotta et al, 2002). The OFC was manually traced in the coronal plane (Fig 1).…”

Section: Tracing Guidelinesmentioning

confidence: 99%

Volumetric alterations of the orbitofrontal cortex in autism

Girgis

Minshew

Melhem

et al. 2007

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Recent evidence has implicated the orbitofrontal cortex (OFC) in the pathophysiology of social deficits in autism. An MRI-based morphometric study of the OFC was conducted involving 11 children with autism (age range 8.1-12.7 years) and 18 healthy, age-matched controls (age range 8.9-12.8 years). Decreased grey matter volume in the right lateral OFC in the patient group was found, and correlations were observed between social deficits and white, but not grey, matter structures of the OFC. These findings support the role of OFC in autism and warrant further investigations of this structure using structural and functional methodologies.

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Measurement of the orbitofrontal cortex: a validation study of a new method

Cited by 46 publications

References 41 publications

Effects of spatial transformation on regional brain volume estimates

Effects of spatial transformation on regional brain volume estimates

Fronto-limbic brain structures in suicidal and non-suicidal female patients with major depressive disorder

Volumetric alterations of the orbitofrontal cortex in autism

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