Measurement of the hyperelastic properties of ex vivo brain tissue slices

Kaster, T.; Sack, Ingolf; Samani, Abbas

doi:10.1016/j.jbiomech.2011.01.019

Cited by 194 publications

(142 citation statements)

References 29 publications

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“…Ten chicken breasts and two rat breasts (the same in-vitro breast samples used in the EIS experiment) were tested within five hours post-mortem interval, consistence with other studies [36][37][38]. To exclude the effect of fibers and, hence, anisotropic character of soft tissues in the study, samples were cut from transverse slices of the tissues in rectangular shape samples and compression testing was performed transversely perpendicular to the matrix of the fibers [2,[39][40][41]. Five samples from each chicken breast and one sample from each rat breast were prepared and compressed.…”

Section: Experimental Setup and Proceduresmentioning

confidence: 99%

Compression-dependency of soft tissue bioimpedance for in-vivo and in-vitro tissue testing

Moqadam

Grewal

Shokoufi

et al. 2015

Journal of Electrical Bioimpedance

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The present study determines the effect of compression over bioimpedance of healthy soft tissue (in-vitro and in-vivo). Electrical impedance spectroscopy (EIS) is a promising tissue characterization and tumor detection technique that uses tissue impedance or admittance to characterize tissue and identify tissue properties as well as cell structure. Variation in EIS measurements while applying pressure suggests that compression tends to affect soft tissue bioimpedance. Moreover, the displacements in tissue caused by applied compression may provide useful information about the structure and state of the tissue. Thus combining the changes to the electrical properties of tissue resulted by applied compression, with the changes in tissue displacements caused by applied compression, and consequently measuring the effect that electrical and mechanical properties have on each other, can be useful to identify tissue structure. In this study, multifrequency bioimpedance measurements were performed on in-vitro and invivo soft tissue at different pressure levels. Increasing compression on the in-vitro tissue results in an increase in both extracellular resistance and membrane capacitance while it causes a reduction in the intracellular resistance. However, as the compression over the in-vivo samples increases, the intracellular and extracellular resistance increase and the membrane capacitance decreases. The in-vivo measurements on human body are also tested on contralateral tissue sites and similar tissue impedance variation trends are observed in the contra-lateral sites of human body. The evidence from these tests suggests the possibility of using this EIS-Pressure combined measurement method to improve tumor detection in soft tissue. Based upon the observations, the authors envision developing an advanced model based upon the Cole model, which is dependent on tissue displacements.

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Section: Experimental Setup and Proceduresmentioning

confidence: 99%

Compression-dependency of soft tissue bioimpedance for in-vivo and in-vitro tissue testing

Moqadam

Grewal

Shokoufi

et al. 2015

Journal of Electrical Bioimpedance

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“…Young's modulus, also known as the tensile or elastic modulus, is a measure of the stiffness of an elastic material. Young's modulus (which used an indentation test apparatus) is about 1800 Pa for white matter and about 1200 Pa for gray matter (Kaster et al, 2011). However, depending on the method and the location of the examination there are different results (Kaster et al, 2011).…”

Section: Different Tissue Structure As Reason For Different Tissue Prmentioning

confidence: 99%

“…Young's modulus (which used an indentation test apparatus) is about 1800 Pa for white matter and about 1200 Pa for gray matter (Kaster et al, 2011). However, depending on the method and the location of the examination there are different results (Kaster et al, 2011). Neuritic fibers are comparable to elastic rubber bands (Van Essen, 1997).…”

Section: Different Tissue Structure As Reason For Different Tissue Prmentioning

confidence: 99%

Increased Tissue Pressure Induces Demyelinated Lesions and Necroses in the Brain

Barz

Schreiber

2015

American Journal of Neuroscience

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A general brain edema increases the size of the brain tissue and stretches the elastic neuronal and glial fibers. Myelinated fibers are more elastic than unmyelinated fibers. The stretching of the neuronal fibers leads particular in regions of the white matter or areas surrounded by myelinated fiber tracts to an increased tissue pressure. This physical principle can be the reason for demyelination and tissue necrosis. The higher the tissue pressure, the lower the blood perfusion. We support the pressure-hypothesis by comparison with well-known pressure related pathologies of the nervous system and other organs. One convincing example is the central pontine myelinolysis. A general or local tissue edema may lead especially in the periventricular and the deep white matter, but also in the cerebellum, the brain stem and the spinal cord to the formation of hypoxemic lesions. In consequence, this could result in diseases like leukoaraiosis, Binswanger encephalopathy, idiopathic intracranial hypertension and Multiple Sclerosis (MS). In cases of brain tissue swelling, capsula-like structures may lead to a rapid increase in tissue pressure within the enclosed areas. This may occur particularly at the optic nerve. A reduced reabsorption of Cerebrospinal Fluid (CSF) can also lead to an increase of the pressure in the Central Nervous System (CNS).

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“…D i is a compressibility coefficient that tends to zero for incompressible tissues. Kaster et al [42] used the model to investigate of hyperelastic properties of brain tissues.…”

Section: Yeoh Elastic Materialsmentioning

confidence: 99%

Remodeling of soft tissues due to cell activity

Stoffel

Weichert

et al. 2014

Proc Appl Math and Mech

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The continuum mechanical modeling of collagenous biological tissues is of interest in the field of biomedical engineering. Particularly, the change of material properties as a result of cell activity is of great interest, as chondrocyte (cartilage cell) implantation yields significant functional improvement. The aim of the contribution is to present the remodeling phenomenon of a cellular material due to cell activity, which results in synthesis of collagen type‐II fibers. For the experimental study, cellular condensed gel is mechanically stimulated in a bioreactor for four weeks. The change of the stiffness of the gel is measured in a compression test. The remodeling process is theoretically derived by an appropriate evolution law in the framework of continuum mechanics. (© 2014 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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Measurement of the hyperelastic properties of ex vivo brain tissue slices

Cited by 194 publications

References 29 publications

Compression-dependency of soft tissue bioimpedance for in-vivo and in-vitro tissue testing

Compression-dependency of soft tissue bioimpedance for in-vivo and in-vitro tissue testing

Increased Tissue Pressure Induces Demyelinated Lesions and Necroses in the Brain

Remodeling of soft tissues due to cell activity

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