Measurement of the efficacy of calcium silicate for the protection and repair of dental enamel

Parker, Alexander S.; Patel, Anisha N.; Botros, Rehab Al; Snowden, Michael E.; McKelvey, Kim; Unwin, Patrick R.; Ashcroft, Alexander T.; Carvell, Mel; Joiner, Andrew; Peruffo, Massimo

doi:10.1016/s0300-5712(14)50004-8

Cited by 56 publications

(72 citation statements)

References 43 publications

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“…AFM provides a three-dimensional surface profile with high resolutions. This technique has been widely used to characterize the erosion of enamel and dentine (Parker et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Effect of self‐assembling peptide P₁₁‐4 on enamel erosion: AFM and SEM studies

et al. 2015

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The aim of the present in vitro study was to evaluate the protective effect of self-assembling peptide P11 -4 (Curodont™ Protect/Credentis) on enamel erosion produced by a soft-drink, by using Atomic Force Microscopy (AFM) and Scanning Electron Microscopy (SEM). Thirty human incisors were equally and randomly assigned to 6 groups. Group 1: intact enamel, group 2: soft drink, group 3: Curodont(™) Protect applied, group 4: Curodont(™) Protect applied + soft drink, group 5: soft drink + Curodont(™) Protect applied, group 6: soft drink + Curodont(™) Protect applied + soft drink. Specimens were observed through atomic force microscopy (AFM). The root mean-square roughness (Rrms) was obtained from the AFM images and the differences in the averaged values among the groups were analyzed by Shapiro-Wilk test in order to assess the normality of the distribution. Parametric ANOVA and post hoc Tuckey test were performed to assess the differences between the different groups. After demineralization process, enamel demonstrated a high degree of surface porosity. This morphological aspect was reflected in the increase of Rrms values. No significant differences (p > 0.05) were reported between intact enamel and enamel only treated with P11 -4 and between eroded enamel and enamel treated with P11 -4 and then demineralized. However significant differences (p < 0.05) were recorded when comparing softened enamel with softened enamel further remineralized with biomimetic self-assembling peptides and enamel treated with the protective paste between two acid attacks. The use of P11 -4 remineralizing may offer a degree of protection from enamel erosion. SCANNING 38:344-351, 2016. © 2015 Wiley Periodicals, Inc.

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“…AFM provides a three-dimensional surface profile with high resolutions. This technique has been widely used to characterize the erosion of enamel and dentine (Parker et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Effect of self‐assembling peptide P₁₁‐4 on enamel erosion: AFM and SEM studies

et al. 2015

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“…Atomic Force Microscopy (AFM) is capable of giving images with atomic resolution with minimal sample preparation. This technique has been widely used to characterize the erosion of enamel and dentin (Parker et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Protective effect of casein phosphopeptide‐amorphous calcium phosphate on enamel erosion: Atomic force microscopy studies

et al. 2015

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The aim of this study was to investigate the in vitro effect of a casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) paste (GC Tooth Mousse- TM, GC Corporation, Tokyo, Japan) on preventing enamel erosion, by using Atomic Force Microscopy (AFM). 30 human incisors, were equally assigned to 6 groups: intact enamel, enamel + soft drink, enamel + TM, enamel + TM + soft drink, enamel + soft drink + TM, enamel + soft drink + TM + soft drink. Specimens were observed through atomic force microscopy (AFM). The most common topographical parameters were determined, such as the surface roughness (Rrms ). The use of soft drink on intact enamel has roughened the surface of the sample. The application of the CPP-ACP paste on non-treated enamel made the surface smoother. A significant decrease in roughness was seen after remineralization with CPP-ACP paste. Significant differences were recorded when comparing softened enamel with softened enamel remineralized with CPP-ACP paste. Comparing eroded enamel with demineralized/remineralized specimens, the application of a CPP-ACP paste leads to a significant reduction in roughness values. AFM images of enamel surface treated with CPP-ACP resulted in less morphological changes of the tooth substrate when compared with the only eroded enamel surface morphology; thus, indicating that CPP-ACP paste promoted remineralization. Specimens' surface roughness remained similar regardless that the protective agent is used before or after exposure to coke or between two demineralizing cycles. The results confirmed the effectiveness of the CPP-ACP paste on preventing enamel erosion produced by soft drinks.

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“…There have been many developments in toothpaste manufacturing to include agents that are effective in reducing dental erosion specifically, as this is recognized as requiring a different approach to that of dental caries [11][12][13]. A recently developed oral care product combines the use of calcium silicate, sodium phosphate salts and fluoride in a novel treatment system to help protect sound enamel from erosive attacks, while repairing acid-softened enamel [8,9,14,15]. The system involves the use of a calcium silicate and sodium phosphate salts plus fluoride containing toothpaste, in conjunction with a dual-phase gel used for 3 consecutive days, once a month.…”

Section: Introductionmentioning

confidence: 99%

“…The system involves the use of a calcium silicate and sodium phosphate salts plus fluoride containing toothpaste, in conjunction with a dual-phase gel used for 3 consecutive days, once a month. Enamel is protected and repaired through the deposition of calcium silicate which facilitates the nucleation of hydroxyapatite (HAP), the predominant mineral in teeth [14,16]. Tooth mineral loss from acid challenges has been shown to be significantly decreased by the application of calcium silicate and by the combined use of calcium silicate and fluoride [8,9,13].…”

Section: Introductionmentioning

confidence: 99%

An interproximal model to determine the erosion-protective effect of calcium silicate, sodium phosphate, fluoride formulations

et al. 2018

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Measurement of the efficacy of calcium silicate for the protection and repair of dental enamel

Cited by 56 publications

References 43 publications

Effect of self‐assembling peptide P₁₁‐4 on enamel erosion: AFM and SEM studies

Effect of self‐assembling peptide P₁₁‐4 on enamel erosion: AFM and SEM studies

Protective effect of casein phosphopeptide‐amorphous calcium phosphate on enamel erosion: Atomic force microscopy studies

An interproximal model to determine the erosion-protective effect of calcium silicate, sodium phosphate, fluoride formulations

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Measurement of the efficacy of calcium silicate for the protection and repair of dental enamel

Cited by 56 publications

References 43 publications

Effect of self‐assembling peptide P11‐4 on enamel erosion: AFM and SEM studies

Effect of self‐assembling peptide P11‐4 on enamel erosion: AFM and SEM studies

Protective effect of casein phosphopeptide‐amorphous calcium phosphate on enamel erosion: Atomic force microscopy studies

An interproximal model to determine the erosion-protective effect of calcium silicate, sodium phosphate, fluoride formulations

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Product

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Effect of self‐assembling peptide P₁₁‐4 on enamel erosion: AFM and SEM studies

Effect of self‐assembling peptide P₁₁‐4 on enamel erosion: AFM and SEM studies