Measurement of the Corpus Callosum Using Magnetic Resonance Imaging in the North of Iran

Abstract

BackgroundMorphometric measurements of the corpus callosum (CC) are important to have normative values according to sex, age and race/ethnicity.ObjectivesThis study was done to measure the size of CC and to identify its gender- and age-related differences in the North of Iran.Patients and MethodsThe size of CC on midsagittal section was measured in 100 (45 males, 55 females) normal subjects using magnetic resonance imaging (MRI) admitted to the Kowsar MRI center in Gorgan–Northern Iran.Longitudinal and vertical dimensions of the CC, longitudinal and vertical lengths of the brain and the length of genu and splenium were measured. Data were analyzed by student’s unpaired t test, ANOVA and regression analysis.ResultsThe anteroposterior length and vertical dimension of the CC, the length of genu and splenium were larger in males than in females, but these differences were not significant. The anteroposterior and vertical lengths of the brain were significantly larger in males than in females (P < 0.05). The length of CC increased with age and regression equations for predicting age were derived from the length of the CC. There was also a positive significant correlation between the anteroposterior length of the CC and the length of the brain and vertical dimension of the CC.ConclusionsThis study showed that various CC parameters vary with the values documented in the Caucasian, Indian and Japanese population.

Analysis of corpus callosum size depending on age and sex

“…In own elaboration, the focus was on simple linear measurements and CC surface measurements, also demonstrating some correlations with the sex differentials of these parameters. It was demonstrated, that there are no statistically significant differences between women and men in terms of parameters related to the size of the CC, such as the length of its sagittal cross section (CD), the thickness in the isthmus (EF), or the area of the sagittal cross section (A1), which is consistent with previous works on CC morphometry [6,11,20,21,32]. Lee et al [18] measured the volume of CC in the 20-year-old and 40-year-old groups of women and men in the Korean population, showing a significantly greater volume of CC in men than in women in the analysed age groups while there was no significant difference in CC volume between the 20-year-old and 40-year-old groups [16].…”

Morphometric Analysis of Corpus Callosum- A Study in Cadaver and Mri

“…age group 7 and the results are similar to the present study except for the correlation between splenial thickness and age. In other studies, the results varies in parameters, which includes an increase in all the measurements except genu 8 decrease in thickness of body 10 and an increase only in length 13,14,15 according to age. The callosal measurements in the present study were almost the same with the previous studies.…”

Corpus Callosum and Ventricle: MRI Determination of Dementia in Turkish Population and Healthy Geriatric Subjects

“…Using the midsagittal T2-weighted spin echo image, the following parameters of corpus callosum (CC) sub-regions were evaluated (Karakasȩ t al. ; Laissy et al;Mohammadi et al;LeMay, 1984;O'Hayon et al, 1998;Gupta et al, 2009;Mourgela et al, 2007;Gupta et al, 2008) (Fig. 1).…”

“…Additionally, the premotor and suplementary motor cortical regions, primary motor and sensory cortex of the two hemispheres relate with the CC body. Parietal, temporal and occipital fibers of hemispheres cross the CC via splenium (Mohammadi et al, 2011). The variations in morphology of CC are seen in Alzheimer disease (AD), depression, schizophrenia, dyslexia, autism (Karakas et al; Mohammadi et al).…”