Measurement of Spontaneous Electrical Activity in the Guinea Pig Pulmonary Bulbus by a Microelectrode

Arita, Makoto; Kawata, Hiroshi; Goto, Masayosi

doi:10.2170/jjphysiol.19.403

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…Ya et al (17) reported that in rat, the distal myocardial boundary of the OT is not a stable landmark but moves proximally over the spiraling course of the pulmonary routes before the semilunar valves develop. Arita et al (18) reported that in guinea pig, microscopical observation showed the myocardium within the pulmonary bulbus to be directly connected to the RV muscle. Although a better understanding of the origin of VT within the PA is needed, we also believe that the origin of arrhythmias within the PA may be related to the short myocardial sleeve extending from the RV to the PA.…”

Section: Discussionmentioning

confidence: 99%

Electrocardiographic and electrophysiologic characteristics of ventricular tachycardia originating within the pulmonary artery

Sekiguchi

Aonuma

Takahashi

et al. 2005

Journal of the American College of Cardiology

141

123

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Section: Discussionmentioning

confidence: 99%

Electrocardiographic and electrophysiologic characteristics of ventricular tachycardia originating within the pulmonary artery

Sekiguchi

Aonuma

Takahashi

et al. 2005

Journal of the American College of Cardiology

141

123

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“…18 Among the several hypotheses for the VPC mechanism, we believe the automaticity observed in the guinea pig pulmonary bulbus could be a potent proof for our modulation theory. 19 Similar automaticity found in the pulmonary vein is a strong rationale for the catheter ablation of atrial fibrillation. 1,20 PIC and its normalized form can clarify the features of the individual VPCs.…”

Section: Limitations and Clinical Implicationsmentioning

confidence: 86%

Ectopic cycle length estimation from the quantified distribution patterns of ventricular bigeminy and trigeminy

Takayanagi¹,

Hori

Sakai

et al. 2021

Heart Rhythm O2

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BACKGROUND Ectopic cycle length (ECL) and the distribution patterns of ventricular bigeminy and trigeminy, expressed as their postextrasystolic intervals (PEIs) and interectopic intervals (IEIs), have been poorly pursued. OBJECTIVE Based on modulation theory, we hypothesized that the PEIs of bigeminy and trigeminy determine their IEIs and ECL. METHODS Ambulatory electrocardiograms of 1290 patients with ventricular premature complexes (3000/day) were studied. To quantify their distribution pattern on the PEI vs IEI curve (PIC), we introduced the following 2 ratios: PEI of trigeminy to PEI of bigeminy ratio (T/B-PEI) and IEI of trigeminy to IEI of bigeminy ratio (T/B-IEI). Distribution patterns were divided into 3 types by T/ B-PEI: standard type (,0.90), intermediate type (between 0.90 and 1.20), and reverse type (.1.20). ECL was defined as the average of the bigeminy and trigeminy intervals in the standard type, and bigeminy intervals in the other 2 types. RESULTS T/B-IEI disclosed significant linear relationship with T/B-PEI (P , .0001). ECLs were longest in the standard type (1905 6 347 ms; n 5 426), followed by the intermediate type (1520 6 239 ms; n 5 607) and reverse type (1317 6 227 ms; n 5 227) (P , .0001). Trigeminy PEI/ECL in the standard type (0.450 6 0.074) was significantly shorter than that of the other 2 types (P , .0001). CONCLUSION We confirmed that T/B-PEI determines T/B-IEI and ECL by discriminating the 3 distribution patterns. Among them, trigeminy PEI/ECL decided the 2 types of modulation by the first sinus QRS, starting at the early delay phase or the later acceleration phase.

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Arrhythmogenic activity of cardiac muscle in pulmonary veins of the dog: implication for the genesis of atrial fibrillation

Chen

Chang

et al. 2000

Cardiovascular Research

250

198

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Objective: Pulmonary veins are important foci of ectopic beats to initiate paroxysmal atrial fibrillation. The purpose of this study were to investigate the electrophysiological characteristics of excitable cells in canine pulmonary veins obtained from healthy and chronic rapid atrial pacing dogs and their responses to cardioactive agents. Methods: Transmembrane action potentials (APs) were recorded from multiple sites of pulmonary veins isolated from 17 healthy dogs and 14 dogs with chronic (6-8 weeks) rapid atrial pacing (780 bpm). Results: In normal superfusate, several types of electrical activities were identified, including silent electrical activity, fast response APs driven by electrical stimulation, and spontaneous fast or slow response APs (with or without early afterdepolarizations). The incidences of AP with an early afterdepolarization (93% versus 41%) was greater in chronic pacing dogs. The spontaneous activities were depressed by beta-adrenoceptor blocker, calcium channel blocker, adenosine and acetylcholine. High frequency (.8 Hz) irregular rhythms occurred spontaneously or were induced by cardioactive agents or electrical stimuli. The incidence of spontaneously occurring tachyarrhythmias was much higher in preparations from chronic pacing dogs (93%) than from control (12%). The tachyarrhythmias were suppressed by sodium channel blocker, potassium channel blocker or magnesium. Conclusions: Pulmonary veins have arrhythmogenic ability through spontaneous activities or high-frequency irregular rhythms. The higher incidence of spontaneously occurring high-frequency irregular rhythms in chronic rapid atrial pacing dogs may account for the increased risk of atrial fibrillation in these dogs.

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Measurement of Spontaneous Electrical Activity in the Guinea Pig Pulmonary Bulbus by a Microelectrode

Cited by 4 publications

References 13 publications

Electrocardiographic and electrophysiologic characteristics of ventricular tachycardia originating within the pulmonary artery

Electrocardiographic and electrophysiologic characteristics of ventricular tachycardia originating within the pulmonary artery

Ectopic cycle length estimation from the quantified distribution patterns of ventricular bigeminy and trigeminy

Arrhythmogenic activity of cardiac muscle in pulmonary veins of the dog: implication for the genesis of atrial fibrillation

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