Measurement of soil/dust arsenic by gas phase chemiluminescence

Sawalha, Maather F.; Sengupta, Mainak; Ohira, Shin Ichi; Idowu, Ademola D.; Gill, Thomas E.; Rojo, Lila; Barnes, Melanie A.; Dasgupta, Purnendu Κ.

doi:10.1016/j.talanta.2008.06.037

Cited by 15 publications

(10 citation statements)

References 55 publications

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“…At 0.85 A, ∼3 sccm O 2 is supplied to CC; this values falls at 0.1 A to ∼0.4 sccm. While it would have been possible to simply generate ozone from air pumped by a miniature air pump, as we have reported in many previous publications, − , and improve the sensitivity, the sub-μg/L LOD still possible under these conditions (vide infra) led us to choose not to further modify the present setup.…”

Section: Resultsmentioning

confidence: 96%

“…We have previously reported on borohydride-based arsine generation coupled to a gas-phase chemiluminescence (GPCL) detector that can differentiate between As(III) and As(V) based on reaction pH and thus can sensitively measure total As or just As(III), followed by a sequential measurement of As(V) . Several comparative and validation studies of the GPCL detection scheme have been described. − This GPCL detector is sufficiently economical, sensitive, and portable; it is currently being used in South Asia . Sodium borohydride is the primary cost of the analysis; this moisture-sensitive reagent also has a limited lifetime in tropical climate.…”

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confidence: 99%

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Oxidation State-Differentiated Measurement of Aqueous Inorganic Arsenic by Continuous Flow Electrochemical Arsine Generation Coupled to Gas-Phase Chemiluminescence Detection

Sengupta

Dasgupta

2011

Anal. Chem.

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The electrochemical reduction of inorganic As on a graphite cathode depends on the current density. We observed that while only inorganic As(III) is reduced to AsH(3) at low current densities, at high current densities both forms of inorganic As are reduced. We describe a unique electrochemical reactor in which the cylindrical anode compartment is isolated from the outer concentric cathode compartment by a Nafion tube in which a hole is deliberately made and the entire anode compartment is inside the cylindrical cavity of a small volume (∼115 μL) cathode chamber. The evolved arsine is then quantitated by gas-phase chemiluminescence (GPCL) reaction with ozone; the latter is generated from oxygen formed during electrolysis. For the dimensions used, inorganic As(III) can be selectively determined at a current of 0.1 A while total inorganic As (both As(III) and As(V)) respond equally at an applied electrolysis current at 0.85 A, without any sample treatment. For a 1-mL sample, the system provides a limit of detection (LOD, S/N = 3) of 0.09 μg/L for total As (i = 0.85 A) and an LOD of 0.76 μg/L for As(III) (i = 0.10 A); As(V) is obtained by difference. Comparison of ICP-MS results for total As in groundwater samples that span a large range of concentration and total inorganic As determined by the present method showed a high correlation (r(2) = 0.9975) and a near unity slope. The basic electrochemical arsine generation technique and current-differentiated oxidation state speciation should be applicable as the front end to many other arsenic measurements techniques, including atomic spectrometry.

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Section: Resultsmentioning

confidence: 96%

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confidence: 99%

Oxidation State-Differentiated Measurement of Aqueous Inorganic Arsenic by Continuous Flow Electrochemical Arsine Generation Coupled to Gas-Phase Chemiluminescence Detection

Sengupta

Dasgupta

2011

Anal. Chem.

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“…It is very flexible, and it achieves a sensitivity of few pMol [1]. Hence, it has been used for detection of explosives [2], environmental control of soil and dusts [3], screening in food [4], bacteria identification [5], biohazard applications [6], and for medical diagnostics [7,8]. The new frontier in diagnosis is point-of-care testing.…”

Section: Introductionmentioning

confidence: 99%

Cancer marker detection in human serum with a point-of-care low-cost system

Grosso

Carrara

Stagni

et al. 2010

Sensors and Actuators B: Chemical

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a b s t r a c tChemiluminescence, i.e. the emission of light from a chemical reaction, offers interesting opportunities for developing point-of-care biosensors. However, commercially available systems are expensive, bulky, and primarily addressed to laboratory usage. The goal of this paper is to present a novel work related to the design and experimental validation of a point-of-care device for cancer marker detection in human serum. The new system has been especially developed for cost-sensitive applications using only lowcost off-the-shelf components. The system was tested with blood serum. The output signal from spots with specific proteins uptake was two orders of magnitude higher than that from control spots: it was 14 ± 3 mV/s from the detection spots, while it was only 260 V/s and 242 V/s from the control spots.

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“…Inductively coupled plasma mass spectrometry (ICPMS) is the benchmark analytical technique for many trace metals because of the high sensitivity and wide dynamic range that it provides; arsenic (As) is no exception. , For arsenic, a monoisotopic element, an isobaric overlap between 75 As + and the 40 Ar 35 Cl + molecular ion causes a problem during quantification. Of several approaches to overcome this issue, the hydride generation (HG) technique is predominant. , Since its introduction, HG has been widely used as a selective means to convert a few elements to their volatile hydrides (or to the element).…”

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An Automated Hydride Generation Interface to ICPMS for Measuring Total Arsenic in Environmental Samples

Sengupta

Dasgupta

2009

Anal. Chem.

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An automated hydride generation (AHG) interface to inductive coupled plasma mass spectroscopy (ICPMS) was developed for measuring arsenic in environmental samples. This technique provides statistically indistinguishable response slopes (within about 3%) for hydride generation-ICPMS (HG-ICPMS) analysis of all major As species, inorganic As(III), dimethylarsinic acid (DMA), monomethylarsonic acid (MMA), and inorganic As(V); this has not previously been achieved. Previously, sample pretreatment to convert all forms of As into As(V) has been a prerequisite for measuring total arsenic in complex matrices. Under our operating conditions, arsenobetaine (AsB), until now regarded to be inert, also generates a hydride (albeit the response is only approximately 7% of others). The limit of detection (LOD) based on three times the standard deviation of the blank with this technique for AsB, DMA, As(III), MMA, and As(V) is 90, 66, 63, 63, and 63 pg As, respectively. This AHG-ICPMS technique was compared with a flow injection-UV photolysis-HG-ICPMS (FI-UV-ICPMS) and liquid chromatography-UV-HG-ICPMS analysis of arsenic content in National Institute of Standards & Technology (NIST) standard rice flour (standard reference material: SRM 1568a) and rice samples collected from West Bengal, India. Both oxidative acid digestion and methanol:water (1:1) extraction were used. The analytical results for total As in the SRM 1568a digest were 99.2 +/- 0.6 and 100.2 +/- 0.8% of the certified value (290 +/- 3 microg As/kg) by the AHG-ICPMS and the FI-UV-HG-ICPMS techniques, respectively. For rice extracts and the digests, the two techniques provided results that were correlated with linear r2 values of 0.9988 and 0.9987 with intercepts statistically indistinguishable from zero. Chromatographic analysis indicated that As in these rice samples were 75-90% inorganic.

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Measurement of soil/dust arsenic by gas phase chemiluminescence

Cited by 15 publications

References 55 publications

Oxidation State-Differentiated Measurement of Aqueous Inorganic Arsenic by Continuous Flow Electrochemical Arsine Generation Coupled to Gas-Phase Chemiluminescence Detection

Oxidation State-Differentiated Measurement of Aqueous Inorganic Arsenic by Continuous Flow Electrochemical Arsine Generation Coupled to Gas-Phase Chemiluminescence Detection

Cancer marker detection in human serum with a point-of-care low-cost system

An Automated Hydride Generation Interface to ICPMS for Measuring Total Arsenic in Environmental Samples

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