2006
DOI: 10.1089/lrb.2006.4.67
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Measurement of Skin Desmosine as an Indicator of Altered Cutaneous Elastin in Draft Horses With Chronic Progressive Lymphedema

Abstract: Chronic progressive lymphedema in draft horses was associated with an initially systemic lower cutaneous elastin level and a deposition of elastin during the progression of the disease. A failure of elastic fibers to appropriately support the skin and its lymphatics is proposed as a possible contributing factor for chronic progressive lymphedema in Shires and Clydesdales.

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Cited by 27 publications
(36 citation statements)
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“…These fibrillin rich structures, which are part of a hierarchical fibrillar elastic apparatus (Gerli et al, 2000), are highly sensitive to interstitial stresses (Swartz and Skobe, 2001) and exert a significant tension on LECs: their main function is to widen the capillary lumen and open the overlapping cell junctions facilitating lymph formation (Cueni and Detmar, 2006). Abnormalities of AFs may reduce adsorption from interstitium and propulsion of lymph and cells and promote pathological conditions such as lymphedema or diseases related to impaired immune responses (De Cock et al, 2006). Dysfunctions may also be induced by extensive and chronic degradation of the ECM that renders lymphatic vessels non-responsive to the changes in the interstitium (Pelosi et al, 2007).…”
Section: Role Of Emilin1 Gc1q In Physiological and Pathological Condimentioning
confidence: 99%
“…These fibrillin rich structures, which are part of a hierarchical fibrillar elastic apparatus (Gerli et al, 2000), are highly sensitive to interstitial stresses (Swartz and Skobe, 2001) and exert a significant tension on LECs: their main function is to widen the capillary lumen and open the overlapping cell junctions facilitating lymph formation (Cueni and Detmar, 2006). Abnormalities of AFs may reduce adsorption from interstitium and propulsion of lymph and cells and promote pathological conditions such as lymphedema or diseases related to impaired immune responses (De Cock et al, 2006). Dysfunctions may also be induced by extensive and chronic degradation of the ECM that renders lymphatic vessels non-responsive to the changes in the interstitium (Pelosi et al, 2007).…”
Section: Role Of Emilin1 Gc1q In Physiological and Pathological Condimentioning
confidence: 99%
“…Symptoms arise secondarily, most likely resulting from a reduced lymphatic drainage in skin and subcutis (De Cock et al . ). In scientific literature, both ‘CPL’ and ‘chronic pastern dermatitis’ (CPD) are used for this multifactorial and incurable disorder (Wallraf et al .…”
Section: Introductionmentioning
confidence: 97%
“…When interstitial fluid pressure increases, anchoring filaments exert tension on LECs, thereby widening the capillary lumen and opening the overlapping cell junctions, which enable fluid and macromolecule uptake and cell entry. It is thought that abnormalities of anchoring filaments may reduce adsorption from the interstitium and propulsion of lymph and cells and promote pathological conditions, such as lymphedema or diseases related to impaired immune responses (9,18). Furthermore, the perivascular ECM plays an integral role in lymphatic-vessel function, as the fluid equilibrium is controlled by the cooperation of both lymphatic function and the ECM (40).…”
mentioning
confidence: 99%