Measurement of serum hyaluronic acid in patients with chronic hepatitis C and its relationship to liver histology

McHutchison, John G.; Blatt, Lawrence M.; Medina, Montserrat; Craig, John R.; Conrad, Andrew; Schiff, E.; Tong, Myron J.

doi:10.1046/j.1440-1746.2000.02233.x

Cited by 209 publications

(167 citation statements)

References 26 publications

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“…Furthermore, to evaluate diffuse liver diseases in a reliable manner, a specimen sample measuring at least 15 mm is needed. 24 Bedossa et al 7 showed recently that only 65% of biopsies relying on 15-mm samples led to correct diagnoses (using the METAVIR score), whereas 75% of biopsies relying on 25-mm samples were correct. Because there were no benefits to taking bigger samples, the investigators suggested that 25-mm samples are necessary to evaluate fibrosis accurately.…”

Section: Discussionmentioning

confidence: 99%

FIB-4: An inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest

et al. 2007

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Section: Discussionmentioning

confidence: 99%

FIB-4: An inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest

et al. 2007

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“…Vários estudos têm utilizado o AH como preditor de fibrose nos pacientes com HCC (7,12,13,15,27) . Nossos achados corroboram os de Halfon et al (7) , que reuniram 405 portadores de HCC para avaliar a acurácia desse marcador em predizer o estádio da fibrose hepática, e concluíram que o AH poderia ser usado clinicamente como marcador não-invasivo para fibrose e/ou cirrose.…”

Section: Discussionunclassified

Valor preditivo de marcadores séricos de fibrose hepática em pacientes portadores de hepatite crônica viral C

Lima¹,

Martins

Nader

et al. 2008

J. Bras. Patol. Med. Lab.

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Introdução: Os marcadores séricos têm sido empregados na avaliação da fibrose hepática em pacientes portadores de hepatite crônica C (HCC). Objetivos: Avaliar a capacidade do índice aspartato aminotransferase (AST)/alanina aminotransferase (ALT), dos níveis séricos de gama-glutamiltransferase (GGT), contagem de plaquetas, do índice AST/plaquetas (APRI) e do ácido hialurônico (AH) em predizer a intensidade da fibrose hepática na HCC e a variação desses marcadores após tratamento com interferon. Pacientes e métodos: Em 72 pacientes portadores de hepatite C determinamos no soro o índice AST/ALT, GGT, plaquetas, índice APRI (obtido pelo quociente AST/plaquetas) e o AH, que foram comparados ao estadiamento histológico, segundo os critérios de METAVIR. Receberam tratamento com interferon e ribavirina 65 pacientes. Os indivíduos que concluíram o tratamento (n = 33) realizaram nova dosagem dos marcadores séricos de fibrose para comparar com os níveis pré-tratamento. Resultados: Observamos que a GGT, a contagem de plaquetas, o índice APRI e o AH se correlacionaram com estádio de doença hepática (p < 0,01), exceto o índice AST/ALT. A análise das áreas sob as curvas ROC (AUC) evidenciaram que a melhor associação com estadiamento hepático foi para o índice APRI e a dosagem sérica do AH: AUC (APRI) = 0,85 e AUC (AH) = 0,86. Na avaliação pós-terapia com interferon, apenas a GGT e o índice APRI apresentaram redução de seus níveis (p < 0,05). Conclusão: O AH e o índice APRI apresentaram maior acurácia no estadiamento da fibrose, podendo ser aplicados como métodos diagnósticos alternativos na HCC. abstract resumo Introduction: Serum markers have been used in the assessment of liver fibrosis in patients with chronic hepatitis C (CHC). Aims: We evaluated the capacity of aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio, gama-glutamyltransferase (GGT) levels, platelet count, the AST to platelet ratio index (APRI) and serum hyaluronic acid (HA) to predict the intensity of hepatic fibrosis in patients with CHC and the variation of these markers after therapy with interferon. Patients and methods: In 72 patients with hepatitis C, AST/ALT ratio, GGT levels, platelet count, the APRI index (calculated as the ratio of AST to platelets) and

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“…Studies have demonstrated that HA levels correlate with the degree of hepatic fibrosis in patients with chronic HCV. 39,83,84 In alcoholic liver disease, the levels of HA correlate with both the degree of fibrosis and the severity of inflammation. 85 There is a direct linear relationship between HA and procollagen type III amino-terminal peptide (PIIINP) with similar performance by both tests in discriminating between alcoholic patients with and without liver fibrosis.…”

Section: Hamentioning

confidence: 99%

Diagnosis and Quantitation of Fibrosis

2008

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Measurement of serum hyaluronic acid in patients with chronic hepatitis C and its relationship to liver histology

Abstract: Serum HA measurement may be clinically useful to non-invasively assess the degree of fibrosis and cirrhosis. Further prospective studies are warranted to determine the clinical utility of HA as a non-invasive marker of liver fibrosis.

Cited by 209 publications

References 26 publications

FIB-4: An inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest

FIB-4: An inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest

Valor preditivo de marcadores séricos de fibrose hepática em pacientes portadores de hepatite crônica viral C

Diagnosis and Quantitation of Fibrosis

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