Measurement of separate kidney clearance by means of 99mTc-DTPA complex and a scintillation camera

Abstract

A new radioisotopic method of determining the separate glomerular clearance of the kidneys is described. After injection of 99mTc-DTPA, the data from a scintillation camera are recorded by computer. The renal curves are corrected for extrarenal activity and the plasma curve is obtained from a precordial curve. At each instant the slope of the renal curve divided by the corresponding plasma concentration gives the separate clearance value, in the period extending from 80 to 180 s after injection of the tracer. The error and correction factors introduced are discussed. Normal values are established on 25 patients and correspond to inulin clearance values. Left kidney: 60 ml/min (SD=13). Right kidney: 57 ml/min (SD=12). The method is simple for the patient, takes only 20 min, is not dangerous, is particularly applicable to young children and can be repeated frequently in the same patient.

Measurement of Glomerular FiltrationRate by the ^99m< /sup>Tc-DTPA Renogram Is Less Precise than Measured and Predicted Creatinine Clearance

“…However, 99m Tc-DTPA clearance with blood and urinary measurements is still a troublesome technique and a lengthy procedure. The measurement of GFR by the 99m Tc-DTPA renogram was proposed as an answer to the need of simplicity without losing in precision [6, 7, 8]. However, the present study demonstrates that this method is quite inaccurate for the assessment of GFR.…”

“…99m Tc-DTPA holds all the characteristics needed to fulfill usability criteria for the measurement of glomerular filtration rate (GFR) [2, 3, 4, 5, 6, 7, 8]. To ease the procedure, many methods have been introduced to calculate GFR from the 99m Tc-DTPA renogram without blood and urine collection.…”

Extravascular chest wall technetium 99m diethylene triamine penta-acetic acid: implications for the measurement of renal function during renography

“…(4) applied to a renal ROI; Peters et al 1988a, b] from CBP 99mTc-DTPA time-activity curves corrected and uncorrected for extravascular chest wall (ev) activity were then compared in a consecutive series of 35 patients undergoing 99mTc-DTPA gammacamera renography for a variety of indications. A pefirenal ROI, scaled for surface area, was used for background correction, as described by Piepsz et al (1977Piepsz et al ( , 1990. None of these patients was given 99mTc-HSA.…”

“…Most techniques, such as those described by Piepsz et al (1977Piepsz et al ( , 1990, Rutland (1985) and Rehling et al (1985), require a continuous recording of circulating activity. Although it is convenient to base this on a region of interest (ROI) placed over the cardiac blood pool (CBP), it assumes that the detected signal is insignificantly contaminated by activity in the extravascular space, which would principally arise from the posterior chest wall.…”

Quantification of renal haemodynamics with radionuclides

“…Increasing use is being made of the gamma camera for measurement of individual kidney glomerular filtration rate (IKGFR) (Piepsz et al 1977Vivian and Gordon 1983;Rehling et al 1985;Rutland 1985;Peters et al 1987aPeters et al , 1988bDecostre and Salmon 1990a, b) and, more recently, 99mTc-MAG 3 clearance (Tondeur et al 1991). Measurement of differential function is based on the same principles as those for clearance measurement, although it is less labor-intensive, since it does not require a blood sample or correction for kidney depth.…”