Measurement of retinal wall-to-lumen ratio by adaptive optics retinal camera: a clinical research

Meixner, Eva; Michelson, Georg

doi:10.1007/s00417-015-3115-y

Cited by 49 publications

(61 citation statements)

References 40 publications

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“…Concerning arterioles, previous imaging methods had already detected enlargement with age [30]. More recently, in line with our findings, studies using AOC showed the increase of WLR with age in small populations [31]. In addition, WLR anatomical components have been studied individually [6] indicating that aging is associated with a significant increase in wall thickness, whereas internal diameter remained invariant.…”

Section: Discussionsupporting

confidence: 90%

Effects of age, blood pressure and antihypertensive treatments on retinal arterioles remodeling assessed by adaptive optics

Rosenbaum

Mattina

Koch

et al. 2016

Journal of Hypertension

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Section: Discussionsupporting

confidence: 90%

Effects of age, blood pressure and antihypertensive treatments on retinal arterioles remodeling assessed by adaptive optics

Rosenbaum

Mattina

Koch

et al. 2016

Journal of Hypertension

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“…45 This phenomenon is supported by the measurement of retinal vessel wall using adaptive optics retinal camera, and age was associated with the increased wall-to-lumen ratio (WLR) of the retinal arterioles. 46 A significant increase of WLR was found in the middle age group (40–59 years), compared to young group (20–39 years). In the G3 group in the present study, there was no significant drop of the retinal vessel density, possibly indicating intact tissue perfusion.…”

Section: Discussionmentioning

confidence: 82%

Age-Related Alterations in the Retinal Microvasculature, Microcirculation, and Microstructure

Wei

Jiang

Shi

et al. 2017

Invest. Ophthalmol. Vis. Sci.

130

126

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PurposeTo characterize age-related alterations in the retinal microcirculation, microvascular network, and microstructure in healthy subjects.MethodsSeventy-four healthy subjects aged from 18 to 82 years were recruited and divided into four age groups (G1 with age <35 years, G2 with age 35 ∼ 49 years, G3 with age 50 ∼ 64 years, and G4 with age ≥65 years). Custom ultra-high resolution optical coherence tomography (UHR-OCT) was used to acquire six intraretinal layers of the macula. OCT angiography (OCTA) was used to image the retinal microvascular network. The retinal blood flow velocity (BFV) was measured using a Retinal Function Imager (RFI).ResultsCompared to G1, G2 had significant thinning of the retinal nerve fiber layer (RNFL) (P < 0.05), while G3 had thinning of the RNFL and ganglion cell and inner plexiform layer (GCIPL) (P < 0.05), in addition to thickening of the outer plexiform layer (OPL) and photoreceptor layer (PR) (P < 0.05). G4 had loss in retinal vessel density, thinning in RNFL and GCIPL, and decrease in venular BFV, in addition to thickening of the OPL and PR (P < 0.05). Age was negatively related to retinal vessel densities, the inner retinal layers, and venular BFV (P < 0.05). By contrast, age was positively related to OPL and PR (P < 0.05).ConclusionsDuring aging, decreases in retinal vessel density, inner retinal layer thickness, and venular BFV were evident and impacted each other as observed by simultaneous changes in multiple retinal components.

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“…Using AO retinal imaging, WLR can be measured non‐invasively and has been shown to increase with mean blood pressure, body mass index and age . The WLR in healthy individuals is highly predictable from the size of the vessel, with a strong linear relationship (R 2 ~ 0.98) between lumen and total diameter for the gamut of vessels spanning from 10 to 150 μm in size (that is, all except the capillaries) .…”

Section: Scientific Advances With Ao Imaging: Vessel Structurementioning

confidence: 99%

“…48 Using AO retinal imaging, WLR can be measured non-invasively and has been shown to increase with mean blood pressure, body mass index and age. [49][50][51][52] The WLR in healthy individuals is highly predictable from the size of the vessel, with a strong linear relationship (R 2~0 .98) between lumen and total diameter for the gamut of vessels spanning from 10 to 150 μm in size (that is, all except the capillaries). 53 In hypertension the correlation remains strong but some vessels show significant departures from the predicted relationship, with narrowing of the lumen and concomitant thickening of the wall.…”

Section: Lumen and Vessel Wallmentioning

confidence: 99%

Adaptive optics imaging of the retinal microvasculature

Bedggood

Metha

2020

Clinical and Experimental Optometry

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The eye has long been recognised as the window to pathological processes occurring in the brain and other organs. By imaging the vasculature of the retina we have improved the scientific understanding and clinical best practice for a diverse range of conditions, ranging from diabetes, to stroke, to dementia. Mounting evidence suggests that damage to the smallest and most delicate vessels in the body, the capillaries, is the first sign in many vasculopathies. These are the most critical vessels involved in the exchange of metabolites with tissue. Accurate assessment of retinal capillary structure and function would therefore be of great benefit across a broad range of disciplines in medical science; however, their small size does not make this an easy task. This has led to the development of high‐resolution adaptive optics imaging methods to non‐invasively explore retinal microvascular networks in living human eyes. This review describes the present state of the art in the field, the scientific breakthroughs that have been made possible in the understanding of vessel structure and function in health and disease, and future directions for this emerging technology.

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Measurement of retinal wall-to-lumen ratio by adaptive optics retinal camera: a clinical research

Cited by 49 publications

References 40 publications

Effects of age, blood pressure and antihypertensive treatments on retinal arterioles remodeling assessed by adaptive optics

Effects of age, blood pressure and antihypertensive treatments on retinal arterioles remodeling assessed by adaptive optics

Age-Related Alterations in the Retinal Microvasculature, Microcirculation, and Microstructure

Adaptive optics imaging of the retinal microvasculature

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