Measurement of Renal Mercury Uptake by External Counting: Separate Functional Testing of Each Kidney

Raynaud, Claude; Desgrez, A.; Kellershohn, C.; Ricard, S.; Girault, Mathias; Blons, M.

doi:10.1016/s0022-5347(17)62687-9

Cited by 27 publications

(8 citation statements)

References 10 publications

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“…However, this scan does not give evaluation of renal function. Raynaud, Desgrez, and Kellershohn (1969) showed that a quantitative measurement can be made of such a scintigraph for obtaining information on renal function; this is the measurement of the fixation rate of lS7HgC1,.…”

Section: Methodsmentioning

confidence: 99%

Comparison of two electrolyte solutions for short perfusion and hypothermic storage in experimental renal preservation

Grenier

Dauchel

Jaeck

et al. 1973

British Journal of Surgery

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In recent years the need for preserving kidneys has become of great importance because of the development of renal transplantation. The most effective and practical method yet described to preserve kidneys outside the body appears to be immersion in a cooled solution combined with initial perfusion. The aim of the present study was to compare two perfusates routinely used in this procedure: Collins solution and Perfudex. A total of 22 kidneys was removed and stored with one of these perfusates and then autotransplanted. Renal function was monitored by radio‐isotope measurements: 197HgCl2 uptake and radio‐hippuran renography. An assessment of the histological evidence of renal damage was made on preserved kidneys 3 months after transplantation. As judged by the results of these investigations the most satisfactory preservation of kidneys was obtained with the Collins solution. The use of this perfusate allows a storage time of 24 hours without decreased function or morphological changes in the kidneys. Other investigators have also confirmed the efficacy of the Collins solution and have provided further evidence for its superiority over conventional perfusates for kidney preservation. The current use of the Collins solution, as now recommended by the France Transplant Association, makes the future of clinical kidney transplantation more hopeful.

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Section: Methodsmentioning

confidence: 99%

Comparison of two electrolyte solutions for short perfusion and hypothermic storage in experimental renal preservation

Grenier

Dauchel

Jaeck

et al. 1973

British Journal of Surgery

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“…This is rather surprising since fundamental work on functional radionuclide examinations, particularly the kidney (which in Europe is the main field of work in paediatric nuclear medicine), has been accomplished in European laboratories: basic work on renography Brown 1969, 1971); the methodology of quantification of renal function with mercury bichloride (Raynaud et al 1968), overall chromium 51 ethylene diaminetetra-acetic acid (EDTA) clearance measurements (Chantler et al 1969;Brochner-Mortensen 1978), separate clearance calculation by means of external detectors (Oberhausen and Romahn 1968;Piepsz etal. This is rather surprising since fundamental work on functional radionuclide examinations, particularly the kidney (which in Europe is the main field of work in paediatric nuclear medicine), has been accomplished in European laboratories: basic work on renography Brown 1969, 1971); the methodology of quantification of renal function with mercury bichloride (Raynaud et al 1968), overall chromium 51 ethylene diaminetetra-acetic acid (EDTA) clearance measurements (Chantler et al 1969;Brochner-Mortensen 1978), separate clearance calculation by means of external detectors (Oberhausen and Romahn 1968;Piepsz etal.…”

Section: Paediatric Nuclear Medicine In Europementioning

confidence: 99%

Paediatric nuclear medicine

Piepsz

Gordon

Hahn³

1991

Eur J Nucl Med

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Until the 1980s no serious attempts were made to develop paediatric nuclear medicine, as for various reasons many centres were reluctant to perform radionuclide examinations on children. Then two books were published on paediatric nuclear medicine in 1984 and 1985, respectively. In 1987, a group of physicians formed an informal club of paediatricians and nuclear medicine specialists in an effort to improve the relationship and cooperation between these specialties. Carrying out nuclear medicine examinations on children requires a completely different approach than on adults. Suggestions are made and tips given, and the specific problems involved are discussed in detail.

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“…Toutes les mesures sont rapportées à un standard, lui-meme rapporté à la dose injectée et les résultats sont exprimés en pourcentage de la dose injectée. La technique et le mode de calcul de la fixation sont étudiés en détail ailleurs (8). Chez le sujet normal, la fixation exprimée en pourcentage de la dose injectée est de 27 ± 3,5 à droite, et de 26 ± 3,5 à gauche, la différence entre les deux reins étant due à l'interférence hépatique.…”

Section: Atériel Et M éThodesunclassified

“…Le coefficient de variation est de 7% . La reprodueibilité de la méthode étudiée chez les 2 sujets normaux est satisfaisante, dans aucun des 2 cas les différences observées entre 2 mesures faites à 1 an de distance pour l'un et 3 semaines pour l'autre, ne dépassaient la valeur d 'un écart type (8). La fixation globale (somme des fixations droite et gauche) est de 53 ± 6b…”

Section: Atériel Et M éThodesunclassified

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Intérêt de la mesure du taux de la fixation rénale du Hg dans l’étude de l’hypertrophie rénale compensatrice chez l’homme

Raynaud¹,

Schoutens²,

Royer³

1968

Nephron

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La mesure du taux de la fixation rénale du Hg injecté sous forme de Cl₂Hg¹⁹⁷ a été utilisée pour étudier l’importance de l’HC. Cet index rénal permet de mesurer la valeur de la fonction rénale au niveau de chaque rein par comptage externe, sans cathétérisme urétéral. Comparés aux valeurs normales, les taux de fixation obtenus au niveau de chaque rein permettent d’apprécier l’importance du déficit ou le degré de la compensation fonctionnelle. Les résultats obtenus indiquent que: 1) Dans les néphropathies unilatérales ou dans les cas de reins solitaires normaux, le rein sain présente une HC telle que son hyperfixation compense l’hypofixation partielle ou totale du côté opposé. La somme des fixations des 2 reins reste dans les limites normales. 2) Dans les néphropathies bilatérales et très dissymétriques et dans les cas de reins solitaires pathologiques où un rein présente une hypertrophie compensatrice et donc une fixation supérieure à la normale, cette hyperfication est insuffisante pour compenser l’hypofixation de l’autre rein. La somme des fixations est inférieure à la normale. L’importance de l’HC d’un rein paraît donc dépendre essentiellement de l’état de ce rein. Si elle est développée sur un rein sain, elle compense le déficit du côté opposé, elle ne le compense plus si elle est développée sur un rein pathologique.

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Measurement of Renal Mercury Uptake by External Counting: Separate Functional Testing of Each Kidney

Cited by 27 publications

References 10 publications

Comparison of two electrolyte solutions for short perfusion and hypothermic storage in experimental renal preservation

Comparison of two electrolyte solutions for short perfusion and hypothermic storage in experimental renal preservation

Paediatric nuclear medicine

Intérêt de la mesure du taux de la fixation rénale du Hg dans l’étude de l’hypertrophie rénale compensatrice chez l’homme

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