Measurement of Proton Beam Dose-Averaged Linear Energy Transfer Using a Radiochromic Film

An, Seohyeon; Pak, Sang‐il; Jeong, Seonghoon; Min, Soonki; Kim, Tae Jeong; Shin, Dongho; Lim, Young Kyung; Jeong, Jee–Heon; Kim, Haksoo; Lee, Se Byeong

doi:10.14316/pmp.2022.33.4.80

Cited by 2 publications

(1 citation statement)

References 16 publications

(21 reference statements)

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“…Thus, LET is viewed as an appropriate first-order approximation of RBE, especially in the clinically relevant LET range [14,21]. This is a useful approximation to make because LET is a directly observable quantity that can be measured experimentally [22], or computed via analytical and Monte Carlo methods [23]. By optimising PBT treatment plans with respect to dose and LET, one can arrive at a biologically optimal plan within an acceptable margin of error.…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review of LET-Guided Treatment Plan Optimisation in Proton Therapy: Identifying the Current State and Future Needs

McIntyre,

Wilson,

Gorayski

et al. 2023

Cancers

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The well-known clinical benefits of proton therapy are achieved through higher target-conformality and normal tissue sparing than conventional radiotherapy. However, there is an increased sensitivity to uncertainties in patient motion/setup, proton range and radiobiological effect. Although recent efforts have mitigated some uncertainties, radiobiological effect remains unresolved due to a lack of clinical data for relevant endpoints. Therefore, RBE optimisations may be currently unsuitable for clinical treatment planning. LET optimisation is a novel method that substitutes RBE with LET, shifting LET hotspots outside critical structures. This review outlines the current status of LET optimisation in proton therapy, highlighting knowledge gaps and possible future research. Following the PRISMA 2020 guidelines, a search of the MEDLINE® and Scopus databases was performed in July 2023, identifying 70 relevant articles. Generally, LET optimisation methods achieved their treatment objectives; however, clinical benefit is patient-dependent. Inconsistencies in the reported data suggest further testing is required to identify therapeutically favourable methods. We discuss the methods which are suitable for near-future clinical deployment, with fast computation times and compatibility with existing treatment protocols. Although there is some clinical evidence of a correlation between high LET and adverse effects, further developments are needed to inform future patient selection protocols for widespread application of LET optimisation in proton therapy.

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Section: Introductionmentioning

confidence: 99%

A Systematic Review of LET-Guided Treatment Plan Optimisation in Proton Therapy: Identifying the Current State and Future Needs

McIntyre,

Wilson,

Gorayski

et al. 2023

Cancers

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Feasibility study for the development of multilayered solar cells for proton linear energy transfer depth profile measurement

Jeong,

Kim,

Kim

et al. 2024

Medical Physics

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BackgroundPrevious study proposed a method to measure linear energy transfer (LET) at specific points using the quenching magnitude of thin film solar cells. This study was conducted to propose a more advanced method for measuring the LET distribution.PurposeThis study focuses on evaluating the feasibility of estimating the proton LET distribution in proton therapy. The feasibility of measuring the proton LET and dose distribution simultaneously using a single‐channel configuration comprising two solar cells with distinct quenching constants is investigated with the objective of paving the way for enhanced proton therapy dosimetry.MethodsTwo solar cells with different quenching constants were used to estimate the proton LET distribution. Detector characteristics (e.g., dose linearity and dose‐rate dependency) of the solar cells were evaluated to assess their suitability for dosimetry applications. First, using a reference beam condition, the quenching constants of the two solar cells were determined according to the modified Birks equation. The signal ratios of the two solar cells were then evaluated according to proton LET in relation to the estimated quenching constants. The proton LET distributions of six test beams were obtained by measuring the signal ratios of the two solar cells at each depth, and the ratios were evaluated by comparing them with those calculated by Monte Carlo simulation.ResultsThe detector characterization of the two solar cells including dose linearity and dose‐rate dependence affirmed their suitability for use in dosimetry applications. The maximum difference between the LET measured using the two solar cells and that calculated by Monte Carlo simulation was 2.34 keV/µm. In the case of the dose distribution measured using the method proposed in this study, the maximum difference between range measured using the proposed method and that measured using a multilayered ionization chamber was 0.7 mm. The expected accuracy of simultaneous LET and dose distribution measurement using the method proposed in this study were estimated to be 3.82%. The signal ratios of the two solar cells, which are related to quenching constants, demonstrated the feasibility of measuring LET and dose distribution simultaneously.ConclusionThe feasibility of measuring proton LET and dose distribution simultaneously using two solar cells with different quenching constants was demonstrated. Although the method proposed in this study was evaluated using a single channel by varying the measuring depth, the results suggest that the proton LET and dose distribution can be simultaneously measured if the detector is configured in a multichannel form. We believe that the results presented in this study provide the envisioned transition to a multichannel configuration, with the promise of substantially advancing proton therapy's accuracy and efficacy in cancer treatment.

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Measurement of Proton Beam Dose-Averaged Linear Energy Transfer Using a Radiochromic Film

Cited by 2 publications

References 16 publications

A Systematic Review of LET-Guided Treatment Plan Optimisation in Proton Therapy: Identifying the Current State and Future Needs

A Systematic Review of LET-Guided Treatment Plan Optimisation in Proton Therapy: Identifying the Current State and Future Needs

Feasibility study for the development of multilayered solar cells for proton linear energy transfer depth profile measurement

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