Measurement of plasma choline in acute coronary syndrome: importance of suitable sampling conditions for this assay

Ohkawa, Ryunosuke; Kurano, Makoto; Sakai, Noboru; Kishimoto, Tatsuya; Nojiri, Takefumi; Igarashi, Koji; Hosogaya, Shigemi; Dohi, Tomotaka; Miyauchi, Katsumi; Daida, Hiroyuki; Aoki, Junken; Okubo, Shigeo; Ikeda, Hitoshi; Tozuka, Minoru; Yatomi, Yutaka

doi:10.1038/s41598-018-23009-x

Cited by 14 publications

(7 citation statements)

References 45 publications

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“…Certain AF-related GM features may be attractive candidates for detecting the disease at the self-terminating PAF. Moreover, many clinical studies have investigated the importance of choline as a biomarker for several human diseases, such as acute coronary syndrome (34)(35)(36)(37). The significant association between GM, choline, and atrial diameter (RASLD, LALRD, and LAAPD) has been identified in the current work.…”

Section: Discussionmentioning

confidence: 67%

Different Types of Atrial Fibrillation Share Patterns of Gut Microbiota Dysbiosis

Zuo

Yin

et al. 2020

mSphere

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Dysbiotic gut microbiota (GM) and disordered metabolic patterns are known to be involved in the clinical expression of atrial fibrillation (AF). However, little evidence has been reported in characterizing the specific changes in fecal microbiota in paroxysmal AF (PAF) and persistent AF (psAF). To provide a comprehensive understanding of GM dysbiosis in AF types, we assessed the GM signatures of 30 PAF patients, 20 psAF patients, and 50 non-AF controls based on metagenomic and metabolomic analyses. Compared with control subjects, similar changes of GM were identified in PAF and psAF patients, with elevated microbial diversity and similar alteration in the microbiota composition. PAF and psAF patients shared the majority of differential taxa compared with non-AF controls. Moreover, the similarity was also illuminated in microbial function and associated metabolic alterations. Additionally, minor disparity was observed in PAF compared with psAF. Several distinctive taxa between PAF and psAF were correlated with certain metabolites and atrial diameter, which might play a role in the pathogenesis of atrial remodeling. Our findings characterized the presence of many common features in GM shared by PAF and psAF, which occurred at the self-terminating PAF. Preventative and therapeutic measures targeting GM for early intervention to postpone the progression of AF are highly warranted. IMPORTANCE Atrial fibrillation has been identified to be associated with disordered gut microbiota. Notably, atrial fibrillation is a progressive disease and could be categorized as paroxysmal and persistent based on the duration of the episodes. The persistent atrial fibrillation patients are accompanied by higher risk of stroke and lower success rate of rhythm control. However, the microbial signatures of different categories of atrial fibrillation patients remain unknown. We sought to determine whether disordered gut microbiota occurs in the self-terminating PAF or intestinal flora develops dynamically during atrial fibrillation progression. We found that different types of atrial fibrillation show a limited degree of gut microbiota shift. Gut microbiota dysbiosis has already occurred in mild stages of atrial fibrillation, which might act as an early modulator of disease, and therefore may be regarded as a potential target to postpone atrial fibrillation progression.

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Section: Discussionmentioning

confidence: 67%

Different Types of Atrial Fibrillation Share Patterns of Gut Microbiota Dysbiosis

Zuo

Yin

et al. 2020

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“…Concentrations of WBCho and PlCho increase during the early period of AMI, due to coronary plaque destabilization and stimulation of PLD by macrophages in tissue ischemia. Therefore, it has been suggested that cardiac ischemia can be detected early if choline levels of patients with ischemic symptoms are observed 52,53…”

Section: Resultsmentioning

confidence: 99%

<p>Biomarkers in acute myocardial infarction: current perspectives</p>

Aydın

Uğur

Aydın

et al. 2019

VHRM

328

204

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PurposeAcute myocardial infarction (AMI) is the most common cause of death in the world. Comprehensive risk assessment of patients presenting with chest pain and eliminating undesirable results should decrease morbidity and mortality rates, increase the quality of life of patients, and decrease health expenditure in many countries. In this study, the advantages and disadvantages of the enzymatic and nonenzymatic biomarkers used in the diagnosis of patients with AMI are given in historical sequence, and some candidate biomarkers – hFABP, GPBB, S100, PAPP-A, RP, TNF, IL6, IL18, CD40 ligand, MPO, MMP9, cell-adhesion molecules, oxidized LDL, glutathione, homocysteine, fibrinogen, and D-dimer procalcitonin – with a possible role in the diagnosis of AMI are discussed.MethodsThe present study was carried out using meta-analyses, reviews of clinical trials, evidence-based medicine, and guidelines indexed in PubMed and Web of Science.ResultsThese numerous AMI biomarkers guide clinical applications (diagnostic methods, risk stratification, and treatment). Today, however, TnI remains the gold standard for the diagnosis of AMI. Details in the text will be given of many biomarkers for the diagnosis of AMI.ConclusionWe evaluated the advantages and disadvantages of routine enzymatic and nonenzymatic biomarkers and the literature evidence of other candidate biomarkers in the diagnosis of AMI, and discuss challenges and constraints that limit translational use from bench to bedside.

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“…Plasma choline level was measured using a fully automated colorimetric assay (Alfresa Pharma Corp., Osaka, Japan) 40 . Placenta samples were collected immediately after delivery.…”

Section: Methodsmentioning

confidence: 99%

“…Plasma choline level was measured using a fully automated colorimetric assay (Alfresa Pharma Corp., Osaka, Japan). 40 Placenta samples were collected immediately after delivery. Placenta samples measuring 2 cm × 2 cm × placenta depth (30-100 g) were collected from placental center while excluding amniotic membranes.…”

Section: Sample Collectionmentioning

confidence: 99%

Effects of maternal and fetal choline concentrations on the fetal growth and placental DNA methylation of 12 target genes related to fetal growth, adipogenesis, and energy metabolism

Nakanishi

Funahashi

Fukuoka

et al. 2020

J of Obstet and Gynaecol

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Aim: We performed a birth cohort study involving 124 mother-infant pairs to investigate whether placental DNA methylation is associated with maternal choline status and fetal development. Methods: Plasma choline concentration was assayed longitudinally in the 1st and 3rd trimesters and at termpregnancy in mothers and cord blood. Placental DNA methylation was measured for 12 target candidate genes that are related to fetal growth, adipogenesis, lipid and energy metabolism, or long interspersed nuclear elements. Results: Higher maternal plasma and cord blood choline levels at term tended to associate with lower birthweight (r = −0.246, P < 0.013; r = −0.290, P < 0.002) and body mass index (BMI) at birth (r = 0.344, P < 1E−3; r = −0.360, P < 1E−3). The correlation between maternal plasma choline level and cord blood choline level was relatively modest (r = 0.049, P = 0.639). There was an inverse correlation between placental DNA methylation at the retinoid X receptor alpha (RXRA) gene and maternal plasma choline level

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Measurement of plasma choline in acute coronary syndrome: importance of suitable sampling conditions for this assay

Cited by 14 publications

References 45 publications

Different Types of Atrial Fibrillation Share Patterns of Gut Microbiota Dysbiosis

Different Types of Atrial Fibrillation Share Patterns of Gut Microbiota Dysbiosis

<p>Biomarkers in acute myocardial infarction: current perspectives</p>

Effects of maternal and fetal choline concentrations on the fetal growth and placental DNA methylation of 12 target genes related to fetal growth, adipogenesis, and energy metabolism

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