Measurement of pH, exudate composition and temperature in wound healing: a systematic review

Power, Gillian D; Moore, Zeh; O’Connor, Tom

doi:10.12968/jowc.2017.26.7.381

Cited by 142 publications

(114 citation statements)

References 52 publications

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“…Injured skin is often accompanied by increased tissue metabolism and immune response, such as inflammatory cytokine induced vasodilation, which leads to changes in temperature in the local area. [ 28 ] However, the mild local temperature changes in the wound relative to normal skin is not sufficient to create a sensitive, wound environment‐specific temperature responsive drug delivery system. Current temperature responsive drug delivery systems are primarily responsive to physiological temperatures (around 37 °C), where materials that exhibit lower critical solution temperature (LCST) within 30 to 40 °C are the most frequently used.…”

Section: Stimuli‐responsive Growth Factor Delivery Systems In Tissue mentioning

confidence: 99%

Stimuli‐Responsive Delivery of Growth Factors for Tissue Engineering

Jiang

Zhou

et al. 2020

Adv Healthcare Materials

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Growth factors (GFs) play a crucial role in directing stem cell behavior and transmitting information between different cell populations for tissue regeneration. However, their utility as therapeutics is limited by their short half‐life within the physiological microenvironment and significant side effects caused by off‐target effects or improper dosage. “Smart” materials that can not only sustain therapeutic delivery over a treatment period but also facilitate on‐demand release upon activation are attracting significant interest in the field of GF delivery for tissue engineering. Three properties are essential in engineering these “smart” materials: 1) the cargo vehicle protects the encapsulated therapeutic; 2) release is targeted to the site of injury; 3) cargo release can be modulated by disease‐specific stimuli. The aim of this review is to summarize the current research on stimuli‐responsive materials as intelligent vehicles for controlled GF delivery; Five main subfields of tissue engineering are discussed: skin, bone and cartilage, muscle, blood vessel, and nerve. Challenges in achieving such “smart” materials and perspectives on future applications of stimuli‐responsive GF delivery for tissue regeneration are also discussed.

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Section: Stimuli‐responsive Growth Factor Delivery Systems In Tissue mentioning

confidence: 99%

Stimuli‐Responsive Delivery of Growth Factors for Tissue Engineering

Jiang

Zhou

et al. 2020

Adv Healthcare Materials

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“…Wound healing effected by temperature as body temperature could affect local blood flow and lymphocyte extravasation, moreover temperature is early indicator of infection which determine wound chronicity. [40]. Therefore, we considered body temperature as important factor in our proposed wound assessment system.…”

Section: ) Measuring Body Temperaturementioning

confidence: 99%

An IoT-Based Intelligent Wound Monitoring System

et al. 2019

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Clinical research of wound assessment focused on physical appearance of wound i.e. wound width, shape, color etc. Although, wound appearance is most crucial factors to influence healing process. however, apart from wound appearance other factors also contribute in healing process. Wound internal and external environment is one such factor that may show positive or negative impact on healing. Internet of things extensively popular during last decade, due to its heavy applications in almost all domains i.e. agriculture, health, marketing, banking, home etc. Therefore, in current research we proposed IoT based intelligent wound assessment system, for assessment of wound status and apply entropy and information gain statistics of decision tree to reflect status of wound assessment by categorization of assessment results in one of three class i.e. good, satisfactory or alarming. We implemented decision tree in MATLAB, in which we select ID3 algorithm for decision tree which based on entropy and information gain for the selection of best feature to split the tree. The efficient feature split of decision tree improved training accuracy rate and performance of decision tree.

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“…Temperature of skin is affected by both internal and external (environmental) factors. Wound healing is affected by temperature as body temperature could affect local blood flow and lymphocyte extravasation; moreover, temperature is an early indicator of infection which determines wound chronicity [13].…”

Section: Temperaturementioning

confidence: 99%

Smart Wound Hydration Monitoring Using Biosensors and Fuzzy Inference System

Sattar

Bajwa

Amin

et al. 2019

Wireless Communications and Mobile Computing

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Skin wounds either minor or chronic may heal up with different time durations. But, this time duration of healing could not be easily predicted as healing is affected by different factors, e.g., age, nutrition, medication, and surroundings. Despite these factors, wound characteristic also plays a role in the healing process. Wound characteristics include wound size, wound type, internal and external wound environment, body temperature, body oxygenation, wound hydration, and infection. erefore, monitoring of wound healing also required careful consideration of wound characteristics. Although the healthcare domain contains many applications for detection and monitoring of diseases, the wound care domain requires efficient techniques and sensing systems for the identification of wound biomarkers such as temperature, blood pressure, oxygen, and infection status of wound using biosensors. In the current research, we provide a wound care solution based on a biosensor-based sensing system to measure basic biomarkers, considered as major wound characteristics, i.e., body temperature and body oxygenation, and design a fuzzy inference system to predict their effect on wound hydration, which ultimately recommends necessary actions to boost healing.

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Measurement of pH, exudate composition and temperature in wound healing: a systematic review

Cited by 142 publications

References 52 publications

Stimuli‐Responsive Delivery of Growth Factors for Tissue Engineering

Stimuli‐Responsive Delivery of Growth Factors for Tissue Engineering

An IoT-Based Intelligent Wound Monitoring System

Smart Wound Hydration Monitoring Using Biosensors and Fuzzy Inference System

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