Measurement of particle size distribution in multilayered skin phantoms using polarized light spectroscopy

Bartlett, Matthew; Jiang, Huabei

doi:10.1103/physreve.65.031906

Cited by 11 publications

(7 citation statements)

References 10 publications

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“…13,14 Polystyrene spheres ͑760-nm diameter͒ have strong scattering and negligible absorption in the NIR spectral range and are widely used to simulate tissue scattering. [15][16][17] Several phantoms with the same concentration of polystyrene microspheres and different concentrations of D-glucose were used in the experiments. The sphere concentrations were chosen to provide scattering coefficients s Х 50 and 100 cm Ϫ1 at ϭ 1.31 m ͑typical for tissues in the NIR spectral range͒.…”

Section: Phantomsmentioning

confidence: 99%

Phase-sensitive optical low-coherence reflectometry for the detection of analyte concentrations

Larin¹,

Akkin²,

Esenaliev³

et al. 2004

Appl. Opt.

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Optical techniques may potentially be used for noninvasive glucose sensing. We investigated the application of phase-sensitive optical low-coherence reflectometry (PS-OLCR) to the measurement of analyte concentrations. The dependence of the PS-OLCR signal on the concentration of various analytes, including aqueous solutions of glucose, calcium chloride, magnesium chloride, sodium chloride, potassium chloride, potassium bicarbonate, urea, bovine serum albumin, and bovine globulin, were determined in clear and turbid media. Obtained results demonstrated (1) a high degree of sensitivity and accuracy of the phase measurements of analyte concentrations with PS-OLCR; (2) a concentration-dependent change in the phase-shift for glucose that is significantly greater than that of other analytes sampled over the same physiological range; and (3) a high submillimolar sensitivity of PS-OLCR for the measurement of glucose concentration. Further exploration of the application of PS-OLCR to the noninvasive, sensitive, and specific monitoring of glucose concentration seems warranted.

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Section: Phantomsmentioning

confidence: 99%

Phase-sensitive optical low-coherence reflectometry for the detection of analyte concentrations

Larin¹,

Akkin²,

Esenaliev³

et al. 2004

Appl. Opt.

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“…This technique was first described by Bartlet [15] to form a slurry, and sonicated. The slurry is then placed in the hot bath.…”

Section: Formulationmentioning

confidence: 99%

Quantitative endoscopic imaging elastic scattering spectroscopy: model system/tissue phantom validation

Lindsley

Farkas

2008

SPIE Proceedings

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We have designed and built an imaging elastic scattering spectroscopy endoscopic instrument for the purpose of detecting cancer in vivo. As part of our testing and validation of the system, known targets representing potential disease states of interest were constructed using polystyrene beads of known average diameter and TiO 2 crystals embedded in a two-layer agarose gel. Final construction geometry was verified using a dissection microscope. The phantoms were then imaged using the endoscopic probe at a known incident angle, and the results compared to model predictions. The mathematical model that was used combines classic ray-tracing optics with Mie scattering to predict the images that would be observed by the probe at a given physical distance from a Mie-regime scattering media. This model was used generate the expected observed response for a broad range of parameter values, and these results were then used as a library to fit the observed data from the phantoms. Compared against the theoretical library, the best matching signal correlated well with known phantom material dimensions. These results lead us to believe that imaging elastic scattering can be useful in detection/diagnosis, but further refinement of the device will be necessary to detect the weak signals in a real clinical setting.

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“…They demonstrated the feasibility of measuring the particle size distribution of internal cell structures in vitro by use of polarized light spectroscopy. 18,40 Hielscher et al 13 performed experimental study of the spatial variations of the diffuse-backscattered intensity when linearly polarized light is incident upon highly scattering media. It has been demonstrated that these polarization-dependent surface intensity maps can be used to determine the concentration, size, and anisotropy factor of the particles that constitute the scattering medium.…”

Section: Polarization Algorithmmentioning

confidence: 99%

Theoretical model for assessing multiple scattering and coherence gating on polarized sensitive images

2006

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We develop a Monte Carlo model for optical coherence signal simulation and providing accurate and high resolution information on the birefringence properties of the connective tissues. To understand the polarized sensitive optical coherence tomography imaging mechanism the Monte Carlo technique is generalized for simulation of polarized low-coherent backscattering of optical radiation scattered within the randomly inhomogeneous turbid medium like the connective tissues. The results of simulation demonstrate a good agreement both with the theoretical and experimental predictions.

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Measurement of particle size distribution in multilayered skin phantoms using polarized light spectroscopy

Cited by 11 publications

References 10 publications

Phase-sensitive optical low-coherence reflectometry for the detection of analyte concentrations

Phase-sensitive optical low-coherence reflectometry for the detection of analyte concentrations

Quantitative endoscopic imaging elastic scattering spectroscopy: model system/tissue phantom validation

Theoretical model for assessing multiple scattering and coherence gating on polarized sensitive images

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