Measurement of Naringin from Citrus Fruits by High-Performance Liquid Chromatography – a Review

Csuti, Aron; Sik, Beatrix; Ajtony, Zsolt

doi:10.1080/10408347.2022.2082241

Cited by 8 publications

(8 citation statements)

References 131 publications

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“…Naringin is a flavonoid found primarily in citrus species with especially high level found in grapefruit (Citrus paradisi Macfad. ), bitter orange (Citrus × aurantium L.), and pomelo [Citrus grandis (L.) Osbeck] (Csuti et al, 2022). Administration of naringenin, a commonly occurring flavonoid aglycone, at 10 and 20 mg/kg to sepsis rats model significantly decreased the sepsis-induced apoptosis of kidney cells, and also reduced Bax and raised Bcl-2 expression.…”

Section: Naringeninmentioning

confidence: 99%

Plants’ bioactive secondary metabolites in the management of sepsis: Recent findings on their mechanism of action

et al. 2022

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Sepsis is a severe inflammatory response to systemic infection and is a threatening cause of death in intensive care units. In recent years, a number of studies have been conducted on the protective effect of natural products against sepsis-induced organ injury. However, a comprehensive review of these studies indicating the mechanisms of action of the bioactive compounds is still lacking. In this context, this review aimed to provide an updated analysis of the mechanism of action of plants’ secondary metabolites in the management of sepsis. Scopus, Science Direct, Google Scholar, and PubMed were searched from inception to July 2022. A variety of secondary metabolites were found to be effective in sepsis management including allicin, aloin, cepharanthine, chrysin, curcumin, cyanidin, gallic acid, gingerol, ginsenoside, glycyrrhizin, hesperidin, kaempferol, narciclasine, naringenin, naringin, piperine, quercetin, resveratrol, rosmarinic acid, shogaol, silymarin, sulforaphane, thymoquinone, umbelliferone, and zingerone. The protective effects exerted by these compounds can be ascribed to their antioxidant properties as well as induction of endogenous antioxidant mechanisms, and also via the downregulation of inflammatory response and reduction of biochemical and inflammatory markers of sepsis. These findings suggest that these secondary metabolites could be of potential therapeutic value in the management of sepsis, but human studies must be performed to provide strength to their potential clinical relevance in sepsis-related morbidity and mortality reduction.

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Section: Naringeninmentioning

confidence: 99%

Plants’ bioactive secondary metabolites in the management of sepsis: Recent findings on their mechanism of action

et al. 2022

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“…Naringin (NG) (4′,5,7—trihydroxy flavanone 7—rhamnoglucoside), a natural plant phenolic, is a flavanone-7-O-glycoside formed between the aglycon naringenin and the disaccharide neohesperidose, composed of a glucose and a rhamnose subunits ( Figure 1 ). Its structure was explained for the first time in 1928 [ 1 ]. NG is mainly extracted from grapes and citrus fruits [ 2 ], the highest concentrations being found in the peel of grapefruit, Citrus paradisi (3.25%) and bitter orange, Citrus aurantium (2.11%) conferring them the bitter taste [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…Its structure was explained for the first time in 1928 [ 1 ]. NG is mainly extracted from grapes and citrus fruits [ 2 ], the highest concentrations being found in the peel of grapefruit, Citrus paradisi (3.25%) and bitter orange, Citrus aurantium (2.11%) conferring them the bitter taste [ 1 ]. Studies revealed that the NG levels in plants decrease with their development towards maturity due to the conversion of this bioflavonoid into non-bitter compounds such as aglycone naringenin (NGN) [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Studies revealed that the NG levels in plants decrease with their development towards maturity due to the conversion of this bioflavonoid into non-bitter compounds such as aglycone naringenin (NGN) [ 3 ]. NG was also detected in dried rosemary leaves (1261 mg/kg), in certain orchid-type leaves (110 mg/kg), peppermint (20 mg/kg), tomatoes (0.88 mg/kg) and other herb species [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…was necessary. A recent review presents an overview of the extraction and sample preparation methods for NG chromatographic analysis from citrus fruits [ 1 ]. NG is a chiral compound and the ratio of the optically active isomers depends on the fruit maturation state [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Electroanalysis of Naringin at Electroactivated Pencil Graphite Electrode for the Assessment of Polyphenolics with Intermediate Antioxidant Power

et al. 2022

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A simple and rapid differential pulse voltammetric (DPV) method using a single-use electroactivated pencil graphite electrode (PGE*) is proposed for the rapid screening of the total content of polyphenolics (TCP) with intermediate antioxidant power (AOP) in grapefruit peel and fresh juice. The results were compared and correlated with those provided by the HPLC-DAD-MS method. NG voltammetric behavior at PGE* was studied by cyclic voltammetry and an oxidation mechanism was suggested. The experimental conditions (type of PGE, electroactivation procedure, pH, nature and concentration of supporting electrolyte) for NG DPV determination were optimized. The NG peak current varied linearly with the concentration in the ranges 1.40 × 10−6–2.00 × 10−5 and 2.00 × 10−5–1.40 × 10−4 mol/L NG and a limit of detection (LoD) of 6.02 × 10−7 mol/L NG was attained. The method repeatability expressed as relative standard deviation was 7.62% for the concentration level of 2.00 × 10−6 mol/L NG. After accumulation for 240 s of NG at PGE* the LoD was lowered to 1.35 × 10−7 mol/L NG, the linear range being 6.00 × 10−7–8.00 × 10−6 mol/L NG. The developed electrochemical system was successfully tested on real samples and proved to be a cost-effective tool for the simple estimation of the TCP with intermediate AOP in citrus fruits.

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Shatianyu dietary fiber (Citrus grandis L. Osbeck) promotes the production of active metabolites from its flavonoids during in vitro colonic fermentation

Deng,

Ye,

Zhang

et al. 2024

J Sci Food Agric

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BACKGROUNDRecent studies reveal that dietary fiber (DF) might play a critical role in the metabolism and bioactivity of flavonoids by regulating gut microbiota. We previously found that Shatianyu (Citrus grandis L. Osbeck) pulp was rich in flavonoids and DF, and Shatianyu pulp flavonoid extracts (SPFEs) were dominated by melitidin, obviously different from other citrus flavonoids dominated by naringin. The effects of Shatianyu pulp DF (SPDF) on the microbial metabolism and bioactivity of SPFEs is unknown.RESULTSAn in vitro colonic fermentation model was used to explore the effects of SPDF on the microbial metabolism and antioxidant activity of SPFEs in the present study. At the beginning of fermentation, SPDF promoted the microbial degradation of SPFEs. After 24 h‐fermentation, the supplemented SPFEs were almost all degraded in SPFEs group, and the main metabolites detected were the dehydrogenation, hydroxylation and acetylation products of naringenin, the aglycone of the major SPFEs components. However, when SPFEs fermented with SPDF for 24 h, 60.7% of flavonoid compounds were retained, and SPFEs were mainly transformed to the ring fission metabolites, such as 3‐(4‐hydroxyphenyl) propionic acid, 3‐phenylpropionic acid and 3‐(3‐hydroxy‐phenyl) propionic acid. The fermentation metabolites of SPFEs showed stronger antioxidant activity than the original ones, with a further increase in SPDF supplemented group. Furthermore, SPFEs enriched microbiota participating in the deglycosylation and dehydrogenation of flavonoids, while co‐supplementation of SPDF and SPFEs witnessed the bloom of Lactobacillaceae and Lactobacillus, contributing to the deglycosylation and ring fission of flavonoids.CONCLUSIONSDPF promote SPFEs to transform to active metabolites probably by regulating gut microbiota. © 2023 Society of Chemical Industry.

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Measurement of Naringin from Citrus Fruits by High-Performance Liquid Chromatography – a Review

Cited by 8 publications

References 131 publications

Plants’ bioactive secondary metabolites in the management of sepsis: Recent findings on their mechanism of action

Plants’ bioactive secondary metabolites in the management of sepsis: Recent findings on their mechanism of action

Electroanalysis of Naringin at Electroactivated Pencil Graphite Electrode for the Assessment of Polyphenolics with Intermediate Antioxidant Power

Shatianyu dietary fiber (Citrus grandis L. Osbeck) promotes the production of active metabolites from its flavonoids during in vitro colonic fermentation

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