Measurement of muscle strength with a handheld dynamometer in patients with chronic spinal muscular atrophy

Febrer, Anna; Rodrı́guez, Natalia; Alías, Laura; Tizzano, Eduardo F.

doi:10.2340/16501977-0507

Cited by 22 publications

(29 citation statements)

References 17 publications

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“…19 This observation also recalls the relative vulnerability of different motor neuron pools in SMA; some muscle groups are more affected while others are relatively spared. 2,26 In contrast to our prior short-term clinical observation, 11 neither ambulatory status at baseline nor gender were significantly associated with longer-term pulmonary outcome although female subjects still tended to have a more pronounced decline in FVC at months 24 and 36 (table e-3). We did, however, observe a greater decline in pulmonary function at 24 and 36 months in those with FVC Ն70% at baseline.…”

Section: Discussioncontrasting

confidence: 50%

“…These findings are consistent with previous reports. 11,16,20,26 CMAP amplitude and AUC, as well as DXA FFMI, all biological measures, were significantly associated with motor function, a clinical measure. On routine laboratory testing, the relatively low creatinine is likely related to decreased muscle mass, while the relatively low CO 2 could be the result of the catabolic state and subtle metabolic acidosis.…”

Section: Discussionmentioning

confidence: 99%

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Prospective cohort study of spinal muscular atrophy types 2 and 3

et al. 2012

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Objective: To characterize the natural history of spinal muscular atrophy type 2 and type 3 (SMA 2/3) beyond 1 year and to report data on clinical and biological outcomes for use in trial planning. Methods:We conducted a prospective observational cohort study of 79 children and young adults with SMA 2/3 who participated in evaluations for up to 48 months. Clinically, we evaluated motor and pulmonary function, quality of life, and muscle strength. We also measured SMN2 copy number, hematologic and biochemical profiles, muscle mass by dual x-ray absorptiometry (DXA), and the compound motor action potential (CMAP) in a hand muscle. Data were analyzed for associations between clinical and biological/laboratory characteristics cross-sectionally, and for change over time in outcomes using all available data. Results:In cross-sectional analyses, certain biological measures (specifically, CMAP, DXA fatfree mass index, and SMN2 copy number) and muscle strength measures were associated with motor function. Motor and pulmonary function declined over time, particularly at time points beyond 12 months of follow-up. Conclusion:

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Section: Discussioncontrasting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Prospective cohort study of spinal muscular atrophy types 2 and 3

et al. 2012

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“…Handgrip strength was measured in both hands using a mechanical hand-held dynamometer, a valid tool for measuring overall muscle strength. 34,35 …”

Section: Methodsmentioning

confidence: 99%

Physical Activity, Fitness, and Cardiometabolic Risk Factors in Adult Survivors of Childhood Cancer with a History of Hematopoietic Cell Transplantation

Slater

Steinberger

Ross

et al. 2015

Biology of Blood and Marrow Transplantation

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Purpose Along with other childhood cancer survivors (CCS), hematopoietic cell transplantation (HCT) survivors are at high risk of treatment-related late effects, including cardiovascular disease and diabetes. Cardiometabolic risk factor abnormalities may be exacerbated by inadequate physical activity (PA). Relationships between PA and cardiometabolic risk factors have not been well described in CCS with HCT. Methods PA (self-report), mobility (Timed Up and Go test), endurance (six-minute walk test), handgrip strength, and cardiometabolic risk factors were measured in 119 HCT survivors and 66 sibling controls aged ≥18 years. Adjusted comparisons between HCT survivors and controls and between categories of low and high PA, mobility, endurance, and strength were performed with linear regression. Results Among HCT survivors, the high PA group had lower waist circumference (WC) (81.9±2.5 v 88.6±3.1 cm±standard error (SE), P=.009) than the low PA group, while the high endurance group had lower WC (77.8±2.6 v 87.8±2.5 cm±SE, P=.0001) and percent fat mass (33.6±1.8 v 39.4±1.7 %±SE, P=.0008) and greater insulin sensitivity (IS) (10.9±1.0 v 7.42±1.14 mg/kg/min±SE via euglycemic insulin clamp, P=.001) than the low endurance group. Differences were greater in HCT survivors than in controls for WC between low and high PA groups, triglycerides between low and high mobility groups, and WC, systolic blood pressure, and IS between low and high endurance groups (all Pinteraction <.05). Conclusions Higher endurance was associated with a more favorable cardiometabolic profile in HCT survivors, suggesting that interventions directed to increase endurance in survivors may reduce the risk of future cardiovascular disease.

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“…Quantitative muscle test performed as a maximal voluntary isometric contraction with a hand-held dynamometer (CitecÔ, C.I.T. Technics BV, Groningen, the Netherlands) and expressed in Newton (N): The reliability of the hand-held dynamometer for use in patients with SMA has been established in several studies [20][21][22].…”

Section: Quantitative Muscle Testmentioning

confidence: 99%

The applicability of four clinical methods to evaluate arm and hand function in all stages of spinal muscular atrophy type II

Werlauff¹,

Steffensen²

2014

Disability and Rehabilitation

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Evaluation of upper limb function in spinal muscular atrophy II Even very weak patients with SMA II have some residual upper limb function that is measurable if the right method is chosen. The Manual muscle test is applicable to all patients with SMA II and is useful to determine possible interventions - such as methods to drive a wheelchair or operate a computer. Abbreviated versions of the EK2 scale and the MFM are useful as methods to evaluate subtle changes in upper limb function resulting from disease progression or interventions.

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Measurement of muscle strength with a handheld dynamometer in patients with chronic spinal muscular atrophy

Abstract: The handheld dynamometer is a valid tool for measuring muscle strength in patients with spinal muscular atrophy. It can be used to measure disease progression and to evaluate changes in therapeutic trials.

Cited by 22 publications

References 17 publications

Prospective cohort study of spinal muscular atrophy types 2 and 3

Prospective cohort study of spinal muscular atrophy types 2 and 3

Physical Activity, Fitness, and Cardiometabolic Risk Factors in Adult Survivors of Childhood Cancer with a History of Hematopoietic Cell Transplantation

The applicability of four clinical methods to evaluate arm and hand function in all stages of spinal muscular atrophy type II

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