Measurement of muscle mass in sarcopenia: from imaging to biochemical markers

Tosato, Matteo; Marzetti, Emanuele; Cesari, Matteo; Savera, Giulia; Miller, Ram R.; Bernabei, Roberto; Landi, Francesco; Calvani, Riccardo

doi:10.1007/s40520-016-0717-0

Cited by 242 publications

(201 citation statements)

References 59 publications

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“…Although, CER is a non‐invasive, easily accessible, inexpensive, and direct measurement of total body muscle mass; it is often not included in the imaging technique armamentarium available and applied for evaluation of muscle mass in clinical intervention studies and observational studies . Each of the imaging techniques that can be applied in clinical intervention and observational studies has its drawbacks, with expenses and availability as most important drawbacks for magnetic resonance imaging and computed tomography, while DEXA and muscle ultrasonography share the major disadvantage of not being able to measure intramuscular adipose tissue . This impedes assessment of muscle quality, a measure which is nowadays more and more appraised as a more important determinant of outcome than quantification of muscle mass without taking intramuscular fat into account .…”

Section: Discussionmentioning

confidence: 99%

Muscle mass determined from urinary creatinine excretion rate, and muscle performance in renal transplant recipients

Stam

Eisenga

Gomes-Neto

et al. 2019

J cachexia sarcopenia muscle

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Background Muscle mass, as determined from 24‐h urinary creatinine excretion rate (CER), is an independent predictor for mortality and graft failure in renal transplant recipients (RTR). It is currently unknown whether CER is comparable with healthy controls after transplantation and whether it reflects muscle performance besides muscle mass. We aimed to compare urinary CER and muscle performance between RTR and healthy controls and to investigate whether urinary CER is associated with muscle performance in RTR. Methods We included RTR, transplanted between 1975 and 2016 in the University Medical Center Groningen. Healthy controls were subjects screened for kidney donation. CER was calculated from a 24‐h urine collection. Muscle performance was assessed by handgrip strength, sit‐to‐stand test, and 2‐min walk test. Statistical analyses were performed using linear regression analyses. Results We included 184 RTR (mean age 56.9 ± 11.9 years, 54% male recipient) and 78 healthy controls (age 57.9 ± 9.9, 47% male recipient). RTR were at a median time of 4.0 (1.1–8.8) years after transplantation. Mean CER was lower in RTR compared to healthy controls (11.7 ± 4.0 vs. 13.1 ± 5.2 mmol/24 h; P = 0.04). Significantly poorer results in muscle performance were found in RTR compared to controls for the handgrip strength (30.5 [23.7–41.1] N vs. 38.3 [29.3–46.0] N, P < 0.001) and the 2‐min walk test (151.5 ± 49.2 m vs. 172.3 ± 12.2 m, P < 0.001) but not for the sit‐to‐stand (12.2 ± 3.3 m vs. 11.9 ± 2.8 m, P = 0.46). In RTR, CER was significantly associated with handgrip strength (std. β 0.33; P < 0.001), independent of adjustment for potential confounders. In RTR, CER was neither associated with the time used for the sit‐to‐stand test (std. β −0.09; P = 0.27) nor with the distance covered during the 2‐min walk test (std. β 0.07; P = 0.40). Conclusions Muscle mass as measured by CER in RTR is lower compared to controls. CER is positively associated with muscle performance in RTR. The results demonstrate that CER does not only reflect muscle mass but also muscle performance in this patient setting. Determination of CER could be an interesting addition to the imaging technique armamentarium available and applied for evaluation of muscle mass in clinical intervention studies and observational studies.

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Section: Discussionmentioning

confidence: 99%

Muscle mass determined from urinary creatinine excretion rate, and muscle performance in renal transplant recipients

Stam

Eisenga

Gomes-Neto

et al. 2019

J cachexia sarcopenia muscle

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“…The determination of decreased muscle mass was termed pre-sarcopenia (3) ; thus, it is necessary to evaluate the other parameters to establish the presence of sarcopenia: assessment of muscle strength and function (3,11) . Despite its importance in clinical nursing practice in the care of the elderly, the evaluation of muscle mass is a challenge in the health services, since its determination requires high cost exams such as magnetic resonance imaging and computed tomography (11)(12) .…”

Section: Introductionmentioning

confidence: 99%

“…Despite its importance in clinical nursing practice in the care of the elderly, the evaluation of muscle mass is a challenge in the health services, since its determination requires high cost exams such as magnetic resonance imaging and computed tomography (11)(12) . Extensive epidemiological studies (5,(13)(14)(15)(16) used Dual Energy X-Ray Absortometry (DEXA) as a reference method to estimate muscle mass, and this method was recommended by the European Consensus of Sarcopenia (3) and for use in scenarios of clinical practice (12,17) .…”

Section: Introductionmentioning

confidence: 99%

Calf circumference: clinical validation for evaluation of muscle mass in the elderly

et al. 2018

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Objective: To validate calf circumference as a technology for assessing muscle mass in the elderly. Method: Cross-sectional study with 132 elderly people from Goiânia, Goiás, Brazil. Decreased muscle mass was determined by the skeletal muscle mass index (IME) using Dual Energy X-Ray Absortometry (DEXA). The cutoff circumferences (CC) cutoff points to indicate muscle mass decrease were estimated by ROC curve, sensitivity, specifi city and accuracy. Results: The most accurate cut-off points for detecting decreased muscle mass in the elderly were 34 cm for men (sensitivity: 71.5%, specifi city: 77.4%) and 33 cm for women (sensitivity: 80.0%; specifi city: 84.6%). Conclusion: CC can be used as a measure for early identifi cation of muscle mass decrease in routine evaluations of the elderly in primary care.

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“…BIA could be a valuable tool to investigate body composition in acute hip fracture patients. There are still concerns that BIA is not sufficiently validated since BIA is influenced by health status and should be validated separately in each population (8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Bones, blood and steel: How bioelectrical impedance analysis is affected by hip fracture and surgical implants

Steihaug

Bogen

Kristoffersen

et al. 2017

Journal of Electrical Bioimpedance

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Introduction Bioelectrical impedance analysis (BIA) is in widespread use, but there is uncertainty about its validity in patients with metal implants or after acute hip fracture and surgery. We aimed to investigate the use of single frequency tetrapolar BIA in patients with hip fracture by answering the following questions: 1) Are BIA measurements affected by recent hip fracture and surgical repair? 2) Are BIA measurements affected by the presence of metal implants used in hip fracture surgery? Setting Two hospitals in Bergen, Norway. Participants A convenience sample of 203 acute hip fracture patients. Methods Participants had their body composition measured by single frequency, tetrapolar BIA on the fractured and unfractured side of the body in the immediate postoperative period and at follow-up three months after hip fracture. Measurements from fractured and unfractured side and measurements in hospital and at follow-up were compared. BIA readings for hips treated with cannulated screws, compression hip screw and hip arthroplasty were compared. Results Resistance was lower on the side of the fractured hip compared to the unfractured side postoperatively, but not at follow-up. BIA readings did not differ by type of surgical implant. Conclusion Recent fracture and surgery influences single frequency tetrapolar BIA resistance. The presence of surgical implants in the hip do not affect BIA measurements. If BIA is used in acute hip fracture patients, the contralateral side to the fracture should be measured.

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Measurement of muscle mass in sarcopenia: from imaging to biochemical markers

Cited by 242 publications

References 59 publications

Muscle mass determined from urinary creatinine excretion rate, and muscle performance in renal transplant recipients

Muscle mass determined from urinary creatinine excretion rate, and muscle performance in renal transplant recipients

Calf circumference: clinical validation for evaluation of muscle mass in the elderly

Bones, blood and steel: How bioelectrical impedance analysis is affected by hip fracture and surgical implants

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