Measurement of 
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 charge- and mass-changing cross sections on H, C, O, and Si targets in the energy range 70–220 MeV/u for radiation transport calculations in ion-beam therapy

Horst, Felix; Aricò, Giulia; Brinkmann, Kai-Thomas; Brons, Stephan; Ferrari, A.; Haberer, Thomas; Mairani, A.; Parodi, Katia; Reidel, Claire-Anne; Weber, Uli; Zink, K.; Schuy, Christoph

doi:10.1103/physrevc.99.014603

Cited by 22 publications

(40 citation statements)

References 48 publications

(93 reference statements)

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“…The majority of the cross section measurements in Table 1 are for carbon projectiles; however, the growing amount of interest in particle therapy with other projectiles has led to recent new initiatives. For instance, valuable new cross section measurements for 4 He [98,99] are displayed in Figure 2. This figure illustrates a general problem with many cross sections: there are differences between data sets, and for analytical or MC model parameterizations, it is ambiguous with which measurements the tuning should be done.…”

Section: Measurements Of Cross Sections On Thin Targetsmentioning

confidence: 99%

Challenges in Monte Carlo Simulations as Clinical and Research Tool in Particle Therapy: A Review

2020

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The use and interest in Monte Carlo (MC) techniques in the field of medical physics have been rapidly increasing in the past years. This is the case especially in particle therapy, where accurate simulations of different physics processes in complex patient geometries are crucial for a successful patient treatment and for many related research and development activities. Thanks to the detailed implementation of physics processes in any type of material, to the capability of tracking particles in 3D, and to the possibility of including the most important radiobiological effects, MC simulations have become an essential calculation tool not only for dose calculations but also for many other purposes, like the design and commissioning of novel clinical facilities, shielding and radiation protection, the commissioning of treatment planning systems, and prediction and interpretation of data for range monitoring strategies. MC simulations are starting to be more frequently used in clinical practice, especially in the form of specialized codes oriented to dose calculations that can be performed in short time. The use of general purpose MC codes is instead more devoted to research. Despite the increased use of MC simulations for patient treatments, the existing literature suggests that there are still a number of challenges to be faced in order to increase the accuracy of MC calculations for patient treatments. The goal of this review is to discuss some of these remaining challenges. Undoubtedly, it is a work for which a multidisciplinary approach is required. Here, we try to identify some of the aspects where the community involved in applied nuclear physics, radiation biophysics, and computing development can contribute to find solutions. We have selected four specific challenges: i) the development of models in MC to describe nuclear physics interactions, ii) modeling of radiobiological processes in MC simulations, iii) developments of MC-based treatment planning tools, and iv) developments of fast MC codes. For each of them, we describe the underlying problems, present selected examples of proposed solutions, and try to give recommendations for future research.

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Section: Measurements Of Cross Sections On Thin Targetsmentioning

confidence: 99%

Challenges in Monte Carlo Simulations as Clinical and Research Tool in Particle Therapy: A Review

2020

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“…10 Except for proton + target → proton + X. 11 A set of total cross sections for helium ions in the therapeutic energy range was recently measured within the scope of their application in ion therapy [42,43]. 12 This situation is currently being partially addressed.…”

Section: Measurement Strategies and Experimental Setupmentioning

confidence: 99%

“…Concerning total reaction cross sections for 4 He-induced reactions, there exists a quite comprehensive database, especially for light targets [42,43,[63][64][65][66][67][68][69][70][71][72][73][74][75][76][77][78][79][80]. Figure 12 shows an overview of this total cross section data set.…”

Section: Total Cross Sectionsmentioning

confidence: 99%

“…Figure 12 shows an overview of this total cross section data set. Recently, measurements of charge-and mass-changing cross sections at therapeutic energies (70-220 MeV/n) were performed at HIT, Heidelberg, because for this energy range there were practically no data available in the literature [42,43]. Accurate nuclear reaction models are required for precise dose calculations and treatment planning in ion therapy [53] and for transport code simulations of dose reduction in space shielding materials [81].…”

Section: Total Cross Sectionsmentioning

confidence: 99%

“…Inclusive 3 He production cross sections can be obtained by subtracting 4 He charge-from mass-changing cross sections. This method has been used to calculate 3 He production cross section data for 4 He projectiles on 12 C, 16 O, and 28 Si targets [42,43]. 3 He production cross sections for 630, 970, and 1,017 MeV/n 4 He projectiles impinging on H targets were reported by 70, 93, 94.…”

Section: Light Ion Fragment Production Partial (Non-differential) Cromentioning

confidence: 99%

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Are Further Cross Section Measurements Necessary for Space Radiation Protection or Ion Therapy Applications? Helium Projectiles

et al. 2020

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The helium (4He) component of the primary particles in the galactic cosmic ray spectrum makes significant contributions to the total astronaut radiation exposure. 4He ions are also desirable for direct applications in ion therapy. They contribute smaller projectile fragmentation than carbon (12C) ions and smaller lateral beam spreading than protons. Space radiation protection and ion therapy applications need reliable nuclear reaction models and transport codes for energetic particles in matter. Neutrons and light ions (1H, 2H, 3H, 3He, and 4He) are the most important secondary particles produced in space radiation and ion therapy nuclear reactions; these particles penetrate deeply and make large contributions to dose equivalent. Since neutrons and light ions may scatter at large angles, double differential cross sections are required by transport codes that propagate radiation fields through radiation shielding and human tissue. This work will review the importance of 4He projectiles to space radiation and ion therapy, and outline the present status of neutron and light ion production cross section measurements and modeling, with recommendations for future needs.

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Development and benchmarking of the first fast Monte Carlo engine for helium ion beam dose calculation: MonteRay

et al. 2022

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Background: Monte Carlo (MC) simulations are considered the gold-standard for accuracy in radiotherapy dose calculation; however, general purpose MC engines are computationally demanding and require long runtimes. For this reason, several groups have recently developed fast MC systems dedicated mainly to photon and proton external beam therapy, affording both speed and accuracy. Purpose: To support research and clinical activities at the Heidelberg Ionbeam Therapy Center (HIT) with actively scanned helium ion beams, this work presents MonteRay, the first fast MC dose calculation engine for helium ion therapy. Methods: MonteRay is a CPU MC dose calculation engine written in C++, capable of simulating therapeutic proton and helium ion beams. In this work, development steps taken to include helium ion beams in MonteRay are presented. A detailed description of the newly implemented physics models for helium ions, for example, for multiple coulomb scattering and inelastic nuclear interactions, is provided. MonteRay dose computations of helium ion beams are evaluated using a comprehensive validation dataset, including measurements of spread-out Bragg peaks (SOBPs) with varying penetration depths/field sizes, measurements with an anthropomorphic phantom and FLUKA simulations of a patient plan. Improvement in computational speed is demonstrated in comparison against reference FLUKA simulations.

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Measurement of He4 charge- and mass-changing cross sections on H, C, O, and Si targets in the energy range 70–220 MeV/u for radiation transport calculations in ion-beam therapy

Cited by 22 publications

References 48 publications

Challenges in Monte Carlo Simulations as Clinical and Research Tool in Particle Therapy: A Review

Challenges in Monte Carlo Simulations as Clinical and Research Tool in Particle Therapy: A Review

Are Further Cross Section Measurements Necessary for Space Radiation Protection or Ion Therapy Applications? Helium Projectiles

Development and benchmarking of the first fast Monte Carlo engine for helium ion beam dose calculation: MonteRay

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