Measurement of Mitral Regurgitation in Man from Simultaneous Atrial and Arterial Dilution Curves after Ventricular Injection

Levinson, Gilbert E.; Stein, Samuel W.; Carleton, Richard A.; Abelmann, Walter H.

doi:10.1161/01.cir.24.4.720

Cited by 16 publications

(3 citation statements)

References 24 publications

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“…F rom th is a d m itte d ly lim ited experience, it w ould appear th a t the detection of an y significant early appearance of dye in the left heart cham bers w ould represent an abnorm al situation pointing to increas ed p u lm o n ary collateral circulation. A lthough it has been suggested th a t there is an increased pulm onary arterial collateral circulation in m itral stenosis [9], none was observed in these lim ited studies. How ever, it has been clearly shown by others th a t in m itral stenosis there is an increase in the size and num ber of bronchial veins [ 10, 111. A 25 year old m ale was studied in a sim ilar m an n er who had con genital absence of th e left pulm onary artery , p a te n t ductus a rte ri osus, and significant pulm onary h y pertension 112].…”

mentioning

confidence: 71%

Studies on Bronchial Arterial Flow and Bronchopulmonary Anastomoses

Averill¹,

Wagner²,

Vogel³

1962

Respiration

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mentioning

confidence: 71%

Studies on Bronchial Arterial Flow and Bronchopulmonary Anastomoses

Averill¹,

Wagner²,

Vogel³

1962

Respiration

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“…During the past 25 years several investigators have tried to develop a method to quantify valvular incompetence. Techniques most commonly employed are cineangiocardiography, indicator dilution technique [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17], and determination of a regurgitant fraction using left ventricular volumes [18][19][20][21]. More recently gated radionuclide angiography and pulsed Doppler echocardiography [27-301 have been extensively investigated.…”

Section: Introductionmentioning

confidence: 99%

Quantification of mitral valvular incompetence

Lopez

Hanson

Orchard

et al. 1985

Cathet. Cardiovasc. Diagn.

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The hemodynamic and angiographic data of 147 individuals were analyzed in an attempt to assess the value of three techniques used in the diagnosis of mitral incompetence. One hundred patients had clinical evidence of mitral incompetence (group A) and 47 had normal hemodynamics (group B). The degree of mitral incompetence was assessed in all 147 individuals by two methods: determination of a regurgitant index (RI) using indicator dilution curves and determination of a regurgitant fraction (RF) using left ventricular volumes. In 26 patients of group A and 26 individuals in group B mitral incompetence was also assessed by cineangiocardiography. Each of these methods was compared with the clinical and hemodynamic evidence of mitral valvular incompetence. Both the determination of RI by dye dilution curves and RF by angiocardiography were found to be useful in separating normal individuals from patients with mitral valvular incompetence. Severe mitral incompetence is associated with an RI greater than 35% and with an RF greater than 55%. The degree of incompetence by either method was not well correlated with any independent hemodynamic variable. The use of cine angiocardiography to quantify the degree of mitral incompetence was found to be too subjective, depending on the observer, and thus less useful.

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“…Vol. 4, January 198 I may be inaccurate due to nonuniform mixing of the indicator with the blood (Armelin et al, 1963;Levinson et al, 1961).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of aortic and mitral valve regurgitation by radionuclide ventriculography: Comparison with the method of sandler and dodge

Kress

Geffers

Stauch

et al. 1981

Clinical Cardiology

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The present investigation was undertaken to introduce a quantitative scintigraphic method for evaluation of regurgitation and to compare it with the generally accepted quantitative method of Sandler and Dodge (Sandler et al., 1963). Radionuclide ventriculography was carried out after injection of 20 mCi 99mtechnetium-labeled red blood cells. Time-activity curves were obtained from the left and right ventricular regions. The ratio (A) of end-diastolic-end-systolic count-rate differences for the left and right ventricles was calculated. The ratio (A) was compared with a hemodynamic ratio (Ah) determined after the method of Sandler and Dodge (1963) with the stroke volume of the left ventricle measured angiographically, and the stroke volume of the right ventricle measured by thermodilution. In 33 patients with aortic and mitral valve regurgitation we found a correlation of r = 0.75 between (A) and Ah). Due to a broad range of normal values of (A) the sensitivity of the scintigraphic method is low. The specificity seems to be high, however, since in 64 patients with all types of heart diseases there were no false positive results. Comparing the described scintigraphic method with other modern or generally accepted methods, the principal advantages are noninvasiveness, good practicability, and the fact that important additional information about the functional state of the heart is gained. This is important in follow-up studies in patients with chronic valvular incompetence. It seems that this method will become a valuable supplement to heart catheterization in the diagnosis of valvular heart disease and may partially replace invasive methods for measuring the regurgitation fraction.

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Measurement of Mitral Regurgitation in Man from Simultaneous Atrial and Arterial Dilution Curves after Ventricular Injection

Abstract: pump (Harvard Apparatus Co., Dover, Mass.) drew blood through 40 em. of polyethylene tubing Circulation, Volume XXIV, October 1961 720 by guest on March 25, 2015 http://circ.ahajournals.org/ Downloaded from

Cited by 16 publications

References 24 publications

Studies on Bronchial Arterial Flow and Bronchopulmonary Anastomoses

Studies on Bronchial Arterial Flow and Bronchopulmonary Anastomoses

Quantification of mitral valvular incompetence

Evaluation of aortic and mitral valve regurgitation by radionuclide ventriculography: Comparison with the method of sandler and dodge

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