Measurement of metabolic heat in a production-scale bioreactor by continuous and dynamic calorimetry

Türker, Mustafa

doi:10.1080/00986440302130

Cited by 18 publications

(22 citation statements)

References 14 publications

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“…Oxygen uptake rate (r o ) and carbon dioxide production rate (r c ) are determined as below using the inert gas balance 29,30 :…”

Section: Methodsmentioning

confidence: 99%

“…Baker's yeast is produced in aerobic fed-batch process. Metabolic behavior of the baker's yeast fermentation process can be defined in three different pathways using the following stoichiometric equations 29,30 : Oxidative growth on carbon source:…”

Section: Growth Stoichiometry Of Yeastmentioning

confidence: 99%

“…Heat balance has been set up around the fermenters to obtain metabolic heat production rate and included as a redundant measurement, which is rarely available in the literature. [28][29][30][31] After the unmeasured conversion rates are calculated, the best estimate values for the measured conversion rates are obtained by recursive application of the reconciliation method.…”

Section: Introductionmentioning

confidence: 99%

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State estimation and error diagnosis in industrial fed‐batch yeast fermentation

Hocalar

Türker²,

Öztürk

2006

AIChE Journal

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“…Oxygen uptake rate (r o ) and carbon dioxide production rate (r c ) are determined as below using the inert gas balance 29,30 :…”

Section: Methodsmentioning

confidence: 99%

Section: Growth Stoichiometry Of Yeastmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

State estimation and error diagnosis in industrial fed‐batch yeast fermentation

Hocalar

Türker²,

Öztürk

2006

AIChE Journal

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“…For that reason, the understanding of the metabolic behavior of the process is essential for successful implementation of control architecture. Metabolic behavior of the baker's yeast fermentation process can be defined in three different pathways using the following stoichiometric equations [26,27].…”

Section: Growth and Stoichiometry Of The Processmentioning

confidence: 99%

“…In order to calculate the unmeasured conversion rates, one first has to derive specific conversion rates from the primary measurements. Oxygen uptake rate (r o ) and carbon dioxide production rate (r c ) are determined as below using inert gas balance [26,27].…”

Section: Calculation Of Conversion Rates and Specific Growth Ratementioning

confidence: 99%

Nonlinear control of large-scale fed-batch yeast fermentation: control of the specific growth rate

Hocalar¹,

Türker²

2014

Turkish J Eng Env Sci

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Abstract:Model-based feedback linearizing control is studied for the control of fed-batch yeast fermentation. For this purpose, the specific growth rate of fed-batch baker's yeast fermentation is controlled with a state feedback linearizing control approach. All control algorithms are constructed on reliable primary measurements, data reconciliation, and state estimations developed previously. The obtained biomass concentrations and specific growth rates are used in the control algorithms. Initially, the results of open-loop specific growth rate controlled fed-batch baker's yeast fermentation are given to show the shortcomings of the existing control method in practice. The state feedback linearizing control of the specific growth rate is then applied to the fed-batch baker's yeast fermentation. Different specific growth rate profiles are investigated and results are presented. The successful implementation of the control of the specific growth rate is shown under the critical specific growth rate value and other limiting factors.

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A Small‐Scale Calorimetric Reactor System Combined with Several Chemical Sensors for the Investigation of Microbial Growth Processes

Hüttl

Harmel

Lißner

et al. 2008

Engineering in Life Sciences

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A miniaturized reactor system based on a small-scale calorimeter (25 mL vessel) equipped with different chemical sensors is presented in this contribution. Apart from the sensor for the detection of the thermal power, the system was equipped with two chemical sensors. In comparison to established calorimeters, this newly designed combination as a whole significantly extends the range of application. The miniaturized chemical sensors can be chosen from a pool of potentiometric and amperometric ones, measuring pH value, redox potential, nitrate and glucose concentrations, as well as dissolved carbon dioxide and oxygen content. The miniaturized sensors were developed by the Kurt-Schwabe-Institute (Meinsberg) and the electrical circuit of the system was designed by IMM (Mittweida). The reactor was tested for batch cultivations using Paracoccus pantotrophus DSM 65 as a model culture.

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Measurement of metabolic heat in a production-scale bioreactor by continuous and dynamic calorimetry

Cited by 18 publications

References 14 publications

State estimation and error diagnosis in industrial fed‐batch yeast fermentation

State estimation and error diagnosis in industrial fed‐batch yeast fermentation

Nonlinear control of large-scale fed-batch yeast fermentation: control of the specific growth rate

A Small‐Scale Calorimetric Reactor System Combined with Several Chemical Sensors for the Investigation of Microbial Growth Processes

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