Measurement of medial temporal lobe atrophy in diagnosis of Alzheimer's disease

Leon, MonyJ. de; Golomb, James; Convit, Antonio; DeSanti, Susan; Mcrae, ThomasD.; George, Allan; Jobst, K; Smith, A.D.

doi:10.1016/0140-6736(93)92610-6

Cited by 35 publications

(15 citation statements)

References 6 publications

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“…However, in spite of the great interindividual variability, our study shows an age-related decline in hippocampal volumes, and a progressive enlargement of ventricular size, indicative of atrophy and volume loss [29]. Indeed, several data seem to indicate that hippocampal atrophy may be related with memory and cognitive changes [58] and that hippocampal atrophy may be considered a risk factor for the development of AD [59,60].…”

Section: Discussionmentioning

confidence: 99%

Association between Changes in Adrenal Secretion and Cerebral Morphometric Correlates in Normal Aging and Senile Dementia

Magri

Terenzi²,

Ricciardi³

et al. 2000

Dement Geriatr Cogn Disord

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The circadian organization of adrenal secretion was studied in 23 healthy elderly subjects, 23 elderly demented patients and 10 healthy young subjects, in order to investigate the relationships between the hypothalamic-pituitary-adrenal axis and some cerebral morphometric parameters. The cerebral morphometric analysis was performed in some subjects of the three groups by MRI. A significant increase in cortisol levels during evening and nighttime was found in both groups of the aged subjects. In elderly subjects, particularly if demented, the mean serum dehydroepiandrosterone sulfate (DHEAs) levels throughout the 24-hour cycle were significantly lower than in young controls. A significant reduction of the hippocampal and temporal volume and an enlargement of the lateral ventricles were found in aged subjects, these changes being significantly related to subjects’ age. Moreover, the hippocampal volume was positively correlated with the circadian mesor of DHEAs (i.e., the circadian rhythm adjusted mean) and with the cortisol nocturnal increase. Our data may suggest the existence of a link between the selective impairment of cortisol secretion and DHEAs levels, and the progression of hippocampal degeneration.

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Section: Discussionmentioning

confidence: 99%

Association between Changes in Adrenal Secretion and Cerebral Morphometric Correlates in Normal Aging and Senile Dementia

Magri

Terenzi²,

Ricciardi³

et al. 2000

Dement Geriatr Cogn Disord

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“…The image data were interpolated inplane to the equivalent of a 512 × 512 matrix and magnified two times. The voxel size of the fully processed image data was 0.316mm 3 . B 1 field inhomogeneity correction was performed.…”

Section: Mri Methodsmentioning

confidence: 99%

“…After the boundaries of the hippocampi had been delineated on each anatomic slice, the number of voxels was calculated automatically with a summing region of interest function. These were multiplied by voxel volume to give a numeric value in mm 3 .…”

Section: Mri Methodsmentioning

confidence: 99%

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Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia

Jack

Dickson²,

Parisi³

et al. 2002

Neurology

527

363

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Objectives-i) to assess the diagnostic specificity of MRI-defined hippocampal atrophy for Alzheimer's disease (AD) among individuals with a variety of pathologically confirmed conditions associated with dementia as well as changes attributable to typical aging, and, ii) to measure correlations among pre-mortem MRI measurements of hippocampal atrophy, mental status exam performance, and the pathologic stage of AD. Methods-An un-selected series of 67 individuals participating in the Mayo Alzheimer's DiseaseResearch Center/Alzheimer's Disease Patient Registry were identified who had undergone a standardized antemortem MRI study and also post-mortem examination. Hippocampal volumes were measured from antemortem MRI. Each post-mortem specimen was assigned a pathologic diagnosis, and in addition, the severity of AD pathology was staged using the method of Braak and Braak.Results-Individuals with an isolated pathologic diagnosis of AD, hippocampal sclerosis, frontotemporal degeneration, and neurofibrillary tangle-only degeneration usually had substantial hippocampal atrophy while those with changes of typical aging did not. Among all 67 subjects, correlations (all p<0.001) were observed between hippocampal volume and Braak stage (r = −0.39), between hippocampal volume and MMSE score (r = 0.60), and between MMSE score and Braak stage (r = −0.41).Conclusions-Hippocampal atrophy, while not specific for AD, was a fairly sensitive marker of the pathologic AD stage [particularly among subjects with isolated AD pathology (r = −0.63, p = 0.001)] and consequent cognitive status.

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“…Previous studies in nontwin samples found that atrophy in either the whole temporal lobe or in selected temporal lobe structures such as the hippocampus, amygdala, parahippocampal gyrus and entorhinal cortex [8,34,35] allowed a differentiation of 85-95% of AD subjects from the nondemented elderly subjects [5]. In this study of twins, both visual and quantitative ratings of lateral and third ventricular and temporal horn dilation effectively discriminated between individuals afflicted with AD and those without, while cerebellar and fourth ventricular size were similar in these 2 groups.…”

Section: Characterization Of Structural Brain Changesmentioning

confidence: 99%

Neuroimaging Findings in Twins Discordant for Alzheimer’s Disease

et al. 1998

Dement Geriatr Cogn Disord

159

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Data from computed tomography (CT) scans of 12 twin pairs in which one partner had Azheimer’s disease (AD) and the other partner is cognitively intact were analyzed to study structural brain features associated with AD while controlling for familial factors. Visual ratings and analysis of quantified areas and volumes indicated that AD twins showed more dilation of temporal horns, lateral ventricles and third ventricle, and more atrophy of temporal lobes, particularly in the anterior temporal/perisylvian area, than their healthy cotwins. Demented twins did not have smaller intracranial areas or overall brain volumes than their intact partners. The apolipoprotein σ-4 allele was associated with greater dilation of lateral ventricles and ventricular volume. Significant intrapair correlations were found for total intracranial area and volume, cerebellar area and white matter lesions.

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Measurement of medial temporal lobe atrophy in diagnosis of Alzheimer's disease

Cited by 35 publications

References 6 publications

Association between Changes in Adrenal Secretion and Cerebral Morphometric Correlates in Normal Aging and Senile Dementia

Association between Changes in Adrenal Secretion and Cerebral Morphometric Correlates in Normal Aging and Senile Dementia

Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia

Neuroimaging Findings in Twins Discordant for Alzheimer’s Disease

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