Measurement of macular structure-function relationships using spectral domain-optical coherence tomography (SD-OCT) and pattern electroretinograms (PERG)

Park, Keunheung; Kim, Jinmi; Lee, Jiwoong

doi:10.1371/journal.pone.0178004

Cited by 21 publications

(14 citation statements)

References 25 publications

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“…The mean deviation for their study groups was –1.89, –0.85, and 0.14, respectively. The results of the study by Park et al 15 coincide with our results as they had an average VF MD of –0.97, –3.23, and –12.2 for their three groups: normal, early glaucoma, and advanced glaucoma, respectively.…”

Section: Discussionsupporting

confidence: 91%

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Pattern electroretinogram changes in patients with primary open-angle glaucoma in correlation with visual field and optical coherence tomography changes

Elgohary

Elbedewy

Saad

et al. 2019

European Journal of Ophthalmology

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Purpose: To study the pattern electroretinogram changes in primary open-angle glaucoma patients in correlation with visual field changes and optical coherence tomography measurements of retinal nerve fiber layer thickness in the peripapillary region in an attempt to evaluate the clinical value of pattern electroretinogram as an objective test of functional deficit in glaucoma. Patients and Methods: The study included 81 eyes of 81 participants: 50 primary open-angle glaucoma patients, 16 primary open-angle glaucoma suspects, and 15 controls. All subjects underwent visual field testing using 24-2 Humphrey standard automated perimetry, peripapillary retinal nerve fiber layer average thickness using the 3.4-mm circular scan of the Heidelberg OCT spectralis and pattern electroretinogram using CSO RetiMax device in accordance with the International Society for Clinical Electrophysiology of Vision guidelines. Results: We had three main groups: normal, glaucoma suspect, and primary open-angle glaucoma patients, and the last group included three subgroups: mild, moderate, and severe. There was significant difference in the visual field mean deviation, peripapillary retinal nerve fiber layer average thickness, and most pattern electroretinogram measured parameters between the three main groups and in between primary open-angle glaucoma subgroups. There was significant positive correlation between visual field mean deviation and the peripapillary retinal nerve fiber layer average thickness, P50 amplitude, and P50–N95 amplitude (p < 0.001, p = 0.018, and p < 0.001, respectively). Significant negative correlation was also found between peripapillary retinal nerve fiber layer average thickness and N95 amplitude (p < 0.001). Significant positive correlation was found between retinal nerve fiber layer average thickness and P50–N95 amplitude (p = 0.001). Significant negative correlation was found between peripapillary retinal nerve fiber layer average thickness and N95 amplitude (p = 0.001) and significant positive correlation of retinal nerve fiber layer average thickness with P50–N95 amplitude (p = 0.017) in primary open-angle glaucoma patients. Conclusion: Peripapillary retinal nerve fiber layer average thickness shows significant negative correlation with pattern electroretinogram N95 amplitude and a significant positive correlation with P50–N95 amplitude. In combination with optical coherence tomography, pattern electroretinogram can be used to objectively assess functional loss in glaucoma.

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Section: Discussionsupporting

confidence: 91%

“…They concluded that pERG amplitude was significantly correlated with GCIPLT in early glaucoma patients, while visual field test results showed no correlation with GCIPLT or pERG. 15…”

Section: Discussionmentioning

confidence: 99%

Pattern electroretinogram changes in patients with primary open-angle glaucoma in correlation with visual field and optical coherence tomography changes

Elgohary

Elbedewy

Saad

et al. 2019

European Journal of Ophthalmology

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“…These results are in general agreement with an earlier report by Park et al ., who did not find a connection between macular GCIPL thickness and VF loss 9 . In that study, a significant association between GCIPL thickness and VF damage was found only in patients with advanced glaucoma 9 . In the present report, patients with early stage glaucoma were included: Mean MD was determined to be −2.8 dB in the PFS group and −2.6 dB in the PNS group.…”

Section: Discussionmentioning

confidence: 84%

“…PERGs are known to generally measure electrical activity upon central stimulation of the macula (typically <15° stimulus field) 3,9 . Recently, several types of PERG were developed in which the visual angle was extended to 44° horizontally, which is similar to the horizontal visual angle (52°) examined by 24-2 standard automated perimetry (SAP 24-2) 5,10 .…”

Section: Introductionmentioning

confidence: 99%

Comparison of pattern electroretinograms of glaucoma patients with parafoveal scotoma versus peripheral nasal step

Jung

Jeon

Kim

et al. 2019

Sci Rep

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Retinal ganglion cells are distributed disproportionately with retinal eccentricity. Pattern electroretinogram (PERG) stimuli resulted in reduced responses with more eccentric stimuli. Therefore, we investigated whether PERG amplitude is associated with the location of visual field (VF) defect in primary open-angle glaucoma. Data from Twenty-nine glaucoma patients with a parafoveal scotoma (PFS) within the central 10° of fixation, 23 glaucoma patients with a peripheral nasal step (PNS), and 27 normal control subjects were analyzed in this study. Electroretinograms (ERGs) were obtained using a commercial ERG stimulator (Neuro-ERG). The thickness of the ganglion cell-inner plexiform layer (GCIPL) was measured using spectral-domain optical coherence tomography. A lower N95 amplitude was observed in both PFS and PNS compared to the normal control (Both P < 0.001). The N95 amplitude of the PFS group was significantly lower than that of the PNS group (P = 0.034). Average GCIPL thickness correlated positively with N95 amplitude (r = 0.368, P = 0.002), but did not correlate significantly with global mean sensitivity (r = 0.228, P = 0.073) or mean deviation on 24-2 standard automated perimetry (r = 0.173, P = 0.176). In conclusion, parafoveal VF defects were associated with the lower PERG amplitude. Therefore, it is necessary to take into account the location of VF defects in evaluating PERGs of glaucoma patients.

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“…Foveal threshold (FT), MD, total deviation (TD), and pattern standard deviation (PSD) were evaluated. TD was divided into three areas (central, midperipheral, and peripheral areas) without Mariotte blind spot ( Fig 1 ) based on the important location of the VF for the quality of vision such as reading and mobility [ 11 ], which were compared by average value for each area. Then, we compared the difference in these parameters among EDOF group, bifocal group and monofocal group.…”

Section: Methodsmentioning

confidence: 99%

Influence of extended depth of focus intraocular lenses on visual field sensitivity

Takahashi¹,

Yamashiro

Yoshimoto

et al. 2020

PLoS ONE

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Purpose To investigate the influence of EDOF IOLs, TECNIS Symfony ® (Johnson & Johnson Surgical Vision, Inc.), on visual field sensitivity and to compare the IOLs with other kinds of IOLs. Methods The subjects included the normal fellow eyes of patients who underwent the Humphrey Field Analyzer (HFA) 30–2 with Swedish Interactive Threshold Algorithm Fast within 6 months after cataract due to glaucoma or suspected glaucoma. Each parameter of HFA was compared among eyes implanted with TENIS Symfony ® (EDOF group), diffractive bifocal IOLs (bifocal group), and monofocal IOLs (monofocal group). Results The total of 76 eyes, including 24 eyes in the EDOF group, 26 eyes in the bifocal group, and 26 eyes in the monofocal group, were included in this study. Mean deviation (MD) of HFA was -0.24±0.58 dB in the EDOF group, -1.38±0.58 dB in the bifocal group, and 0.02±0.44 dB in the monofocal group. Foveal threshold (FT) of HFA was 35.8±1.6 dB in the EDOF group, 33.6±1.7 dB in the bifocal group, and 36.6±1.4 dB in the monofocal group. In both MD and FT, there was significant difference between the bifocal group and the others (p<0.001). There was no difference between the EDOF group and the monofocal group. Moreover, there was no significant difference between the three groups about pattern standard deviation (PSD) of HFA. Conclusion TECNIS Symfony ® may have little influence on visual field sensitivity, whereas diffractive bifocal IOLs decrease visual field sensitivity.

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Measurement of macular structure-function relationships using spectral domain-optical coherence tomography (SD-OCT) and pattern electroretinograms (PERG)

Cited by 21 publications

References 25 publications

Pattern electroretinogram changes in patients with primary open-angle glaucoma in correlation with visual field and optical coherence tomography changes

Pattern electroretinogram changes in patients with primary open-angle glaucoma in correlation with visual field and optical coherence tomography changes

Comparison of pattern electroretinograms of glaucoma patients with parafoveal scotoma versus peripheral nasal step

Influence of extended depth of focus intraocular lenses on visual field sensitivity

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