Measurement of Lamotrigine Under Conditions Measuring Phenobarbitone, Phenytoin, and Carbamazepine Using Reversed-Phase High-Performance Liquid Chromatography at Dual Wavelengths

Simultaneous determination of lamotrigine, phenobarbitone, carbamazepine and phenytoin in human serum by high-performance liquid chromatography

“…For research work related to the study of drug interactions, pharmacokinetic studies and routine therapeutic drug monitoring, analytical methods that can reliably and simultaneously measure LTG and other AEDs are highly desirable. But there are very few HPLC methods for the determination of LTG simultaneously with other AEDs in plasma or serum [14][15][16][17].…”

Simultaneous liquid chromatographic determination of lamotrigine, oxcarbazepine monohydroxy derivative and felbamate in plasma of patients with epilepsy

“…Different simple HPLC-UV procedures based on direct HPLC injection after sample deproteinization or even without sample pretreatment have been reported for the individual determination of LTG [10][11][12][13], MHD [14] and FBM [15,16] in human plasma. Shortcomings of these methods for TDM in patients with epilepsy include the need for dual-wavelength monitoring [10] or a gradient elution [15] to eliminate interferences, low analyte extraction efficiency [14], inadequate limit of quantitation (LOQ) [11], inappropriate choice of the internal standard [16] and short guard column [14] or column life [12]. Only one recently published method allows for the simultaneous determination of LTG and MHD [17], but it requires laborious and expensive sample pre-treatment.…”

Development of a simple column-switching high-performance liquid chromatography (HPLC) method for rapid and simultaneous routine serum monitoring of lamotrigine, oxcarbazepine and 10-monohydroxycarbazepine (MHD)

“…The results were in accordance with previous findings. Lamotrigine areas were comparable within 2 days and peak heights for oxcarbazepine and its metabolite MHD were comparable within 24 h, when kept in the autosampler at room temperature [12,13]. The application of this HPLC method offers the possibility of a simultaneous detection of various antidepressants and neuroleptics within the same run that might be prescribed to patients suffering from bipolar disorders.…”