Measurement of intrarenal plasma flow with antiglomerular basement-membrane antibody

Wallin, J. D.; Rector, Floyd C.; Seldin, Donald W.

doi:10.1152/ajplegacy.1971.221.6.1621

Cited by 26 publications

(10 citation statements)

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“…Few (45) found no differences in plasma flow in outer cortical, midcortical, and inner cortical glomeruli in hydropenic dogs.…”

Section: Resultsmentioning

confidence: 94%

“…DISCUSSION Microspheres with an average diameter of approximately 15 sm lodge in glomerular capillaries without recirculation (29,30,31,44), and after injection into the left ventricle or the root of the aorta, their distribution in the renal cortex reflects the GBFD at the time of injection. However, in comparison of the intrarenal distribution of antiglomerular basement membrane antibody with that of microspheres, Wallin, Rector, and Seldin (45,46) It is well-established that maturation of the kidney follows a centrifugal pattern, the deeper structures at any given age being more mature than those in more superficial regions. Spitzer and Brandis (27) have shown in guinea pigs that during the first few days of life the filtration rate in the outer cortical glomeruli is 1/10th that of the juxtamedullary glomeruli.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Postnatal Changes in Renal Glomerular Blood Flow Distribution in Puppies

Olbing¹,

Blaufox²,

Aschinberg³

et al. 1973

J. Clin. Invest.

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“…Few (45) found no differences in plasma flow in outer cortical, midcortical, and inner cortical glomeruli in hydropenic dogs.…”

Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Postnatal Changes in Renal Glomerular Blood Flow Distribution in Puppies

Olbing¹,

Blaufox²,

Aschinberg³

et al. 1973

J. Clin. Invest.

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“…Glomerular perfusion rate was estimated to be approximately 155 nl/min in superficial nephrons and 170 nl/min in juxtamedullary nephrons (33). If each kidney contained 13,000 glomeruli/g (34), 65% of which were superficial, a renal plasma flow of 104 ml/min could be calculated.…”

Section: Resultsmentioning

confidence: 99%

Mechanism of Natriuresis after Closure of Chronic Arteriovenous Shunts

Mandin¹

1973

J. Clin. Invest.

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A B S T R A C T Animals subjected to certain cardiovascular manipulations, such as arteriovenous fistulas, diminish their urinary sodium excretion. It has been shown that closure of such fistulas results in a prompt increase in the rate of sodium excretion. However, the nature of the renal mechanisms increasing the excretion of sodium when the initial cardiovascular abnormality is corrected has remained unclear. Since the elucidation of such mechanisms might provide information pertinent to other sodium-retaining states, the effect of closure of chronic Teflon-Silastic arteriovenous shunts was studied in desoxycorticosterone acetate (DOCA) -treated dogs by utilizing micropuncture techniques.Nephron filtration rates were measured first during a control period vith open arteriovenous shunts and then again after closure of the shun.s in 12 dogs. Nephron filtration rate rose 32% while total glomerular filtration rate (GFR) decreased 8%. After closure of the arteriovenous shunt, fractional reabsorption increased 6%, while total kidney filtration fraction increased from 0.31 to 0.35. Renal plasma flow decreased from a mean of 111 ml/min to 90 ml/min. Closure of the arteriovenous shunts increased sodium excretion from a mean of 21Aeq/min to 45 Aeq/min. Concomitantlv, a redistribution of filtrate to superficial nephrons occurred. Since pharmacological doses of DOCA wvere being administered while total GFR was not increased and fractional reaisorption of sodium in the proximal tubule was not inhibited, it was concluded that filtrate distribution to superficial nephrons may have contributed to the observed natriuresis, although alternate explanations were also deemed possible.

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“…However, many studies indicate that the microspheres are subject to ski rnming at the origin of the affer ent arterioles and therefore underestimate blood flow in deep glomeruli, and overesti mate superficial glomerular flow [Aukland, 1980: Bankir et al, 1979Clausen et al, 1980;Mimran and Casellas, 1979;0J}ord and Clausen, 1983], A promising attempt to avoid this shortcoming was the use of antiglomerular basement membrane antibody, which is dissolved in plasma and is therefore not subject to skimming. However, while the first report by Wallin et al [1971] showed 96% glomerular extraction of the antibody in one passage through the dog kidney, later studies in dogs [Stein et al, 1973] and rats [Trin Trang Tan et al, 1978] gave far from complete extraction -about 40%. In an attempt to combine the virtues of these two techniques we have studied the extraction of two cationic dyes, alcian blue (AB) and ru thenium red (RR).…”

Section: Introductionmentioning

confidence: 99%

An Attempt to Measure Glomerular Plasma Flow by the Cationic Dyes Alcian Blue and Ruthenium Red

Lavik¹,

Aukland²

1985

Kidney Blood Press Res

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Autoradiography showed that ³H-labelled alcian blue injected into the rat renal artery was concentrated in the glomeruli. To test if the uptake could be used as a measure of local glomerular plasma flow, the one-pass extraction was measured in 19 rats. The average extraction was 31.9% (SD 8.0%). Impurities and heterogeneity of the tracer as well as reversible binding to erythrocytes may have contributed to the low estimated extraction. The average extraction of ¹⁰³Ru-ruthenium red was 26.3%. We conclude that neither of these dyes are suitable for measurement of glomerular plasma flow.

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Measurement of intrarenal plasma flow with antiglomerular basement-membrane antibody

Cited by 26 publications

References 0 publications

Postnatal Changes in Renal Glomerular Blood Flow Distribution in Puppies

Postnatal Changes in Renal Glomerular Blood Flow Distribution in Puppies

Mechanism of Natriuresis after Closure of Chronic Arteriovenous Shunts

An Attempt to Measure Glomerular Plasma Flow by the Cationic Dyes Alcian Blue and Ruthenium Red

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