Measurement of Intraocular Optical Distances Using Partially Coherent Laser Light

Fercher, Adolf Friedrich; Hitzenberger, Christoph K.; Juchem, M.

doi:10.1080/09500349114551491

Cited by 67 publications

(45 citation statements)

References 18 publications

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“…Similarly, various point-of-care diagnostic devices have been developed and among them optical imaging and sensing techniques are highly advantageous as they can provide real-time, highresolution and highly sensitive quantitative information, potentially assisting rapid and accurate diagnosis. [30][31][32][33][34][35][36][37][38][39][40] To date, a number of optical techniques have been proposed for point-of-care diagnostics such as in vitro optical devices, [41][42][43][44][45][46][47][48][49][50][51][52][53] including portable optical imaging systems, optical microscopes integrated to cell phones or in vivo optical devices, [54][55][56][57][58][59][60][61][62][63] involving confocal microscopy, microendoscopy and optical coherence tomography techniques. Among these approaches, lens-free computational on-chip imaging 64 has been an emerging technique that can eliminate the need for bulky and costly optical components while also preserving (or even enhancing in certain cases) the image resolution, field of view and sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Handheld high-throughput plasmonic biosensor using computational on-chip imaging

et al. 2014

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We demonstrate a handheld on-chip biosensing technology that employs plasmonic microarrays coupled with a lens-free computational imaging system towards multiplexed and high-throughput screening of biomolecular interactions for point-of-care applications and resource-limited settings. This lightweight and field-portable biosensing device, weighing 60 g and 7.5 cm tall, utilizes a compact optoelectronic sensor array to record the diffraction patterns of plasmonic nanostructures under uniform illumination by a single-light emitting diode tuned to the plasmonic mode of the nanoapertures. Employing a sensitive plasmonic array design that is combined with lens-free computational imaging, we demonstrate label-free and quantitative detection of biomolecules with a protein layer thickness down to 3 nm. Integrating large-scale plasmonic microarrays, our on-chip imaging platform enables simultaneous detection of protein mono-and bilayers on the same platform over a wide range of biomolecule concentrations. In this handheld device, we also employ an iterative phase retrieval-based image reconstruction method, which offers the ability to digitally image a highly multiplexed array of sensors on the same plasmonic chip, making this approach especially suitable for high-throughput diagnostic applications in field settings.

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Section: Introductionmentioning

confidence: 99%

Handheld high-throughput plasmonic biosensor using computational on-chip imaging

et al. 2014

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“…The technique has evolved rapidly in the past decade from initial investigations of different biological tissues [3][4][5][6][7] to in vivo applications. 8,9 Special attention has been given to applications in ophthalmology, 10 with different setups for measurement of intraocular distances [11][12][13][14] being devised and the technique being used to assess macula health. 15 Lately, the emphasis has shifted steadily toward imaging, 16 and this provides a useful complement to other approaches, e.g., ultrasonography, magnetic resonance, and scanning laser ophthalmoscopy.…”

Section: Introductionmentioning

confidence: 99%

Transversal and Longitudinal Images from the Retina of the Living Eye Using Low Coherence Reflectometry

et al. 1998

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An optical coherence tomography (OCT) system to produce both longitudinal and transversal images of the in vivo human eye is presented. For the first time, OCT transversal images collected from the living eye at 50-m depth steps show details unobtainable with the state-of-the-art scanning laser ophthalmoscope. Images of up to 3ϫ3 mm are produced from the retina in less than a second. For images larger than 1.6ϫ1.6 mm, a path modulation is introduced by the galvanometric scanning mirror and is used as an effective phase modulation method.© 1998 Society of Photo-Optical Instrumentation Engineers. [S1083-3668(98)

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“…The basic idea of using FD PCI for ocular biometry can already be found in an early paper from 1991 by Fercher et al 34 Although the paper deals with TD PCI, the following sentence can be found in the theory section: "Secondly, we can use a spectrometer to evaluate the spectral modulation given by equation (6). Here, D can be obtained from the distance δω of two dark bands in the channeled spectrum."…”

Section: Fourier-domain Optical Coherence Tomographymentioning

confidence: 99%

Adolf Friedrich Fercher: a pioneer of biomedical optics

Hitzenberger

2017

J. Biomed. Opt

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Abstract. Adolf Friedrich Fercher, an outstanding pioneer of biomedical optics, passed away earlier this year. He was a brilliant and visionary researcher who pioneered various fields of biomedical optics, such as laser speckle flowgraphy, tissue interferometry, and optical coherence tomography (OCT). On the occasion of the 25th anniversary of OCT, this paper reviews and commemorates Fercher's pioneering work. © The Authors.Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Measurement of Intraocular Optical Distances Using Partially Coherent Laser Light

Cited by 67 publications

References 18 publications

Handheld high-throughput plasmonic biosensor using computational on-chip imaging

Handheld high-throughput plasmonic biosensor using computational on-chip imaging

Transversal and Longitudinal Images from the Retina of the Living Eye Using Low Coherence Reflectometry

Adolf Friedrich Fercher: a pioneer of biomedical optics

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