Measurement of in Vitro Dissolution of Aerosol Particles for Comparison to in Vivo Dissolution in the Lower Respiratory Tract after Inhalation

Kanapilly, G.M.; Raabe, Otto G.; Goh, C.H.T.; Chimenti, R.

doi:10.1097/00004032-197305000-00004

Cited by 94 publications

(34 citation statements)

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“…The U03 industrial dust from the Comurhex factory in Narbonne (France) (12), Kalkwarf (6), and Ansoborlo et al (9,13 Procedures to obtain these solvents have been described by Ansoborlo et al (9).…”

Section: Samples Of U03mentioning

confidence: 99%

In vitro chemical and cellular tests applied to uranium trioxide with different hydration states.

Ansoborlo¹,

Chalabreysse²,

Hengé-Napoli³

et al. 1992

Environ Health Perspect

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A simple and rapid in Witro chemical solublity test applcable to industrial uranium triode (U03) was dewloped together with two in vitro cellular tests using rat alveolar macrophages maintained either in gas phase or in alginate beads at 37°C Industrial U03 was characterized by particle size, X-ray, and IR spectra, and chemical transformation (e.g., aging and hydration ofthe dust) was also studied. Solvents used for the in ro chemical solubility study included

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Section: Samples Of U03mentioning

confidence: 99%

In vitro chemical and cellular tests applied to uranium trioxide with different hydration states.

Ansoborlo¹,

Chalabreysse²,

Hengé-Napoli³

et al. 1992

Environ Health Perspect

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“…The simulated lung fluid (adapted from Mattson, 1994, andKanapilly andothers, 1973) is produced by dissolving analytical grade chemicals in ultrapure 18-ohm water. Intermediate solutions are made for ammonium chloride, sodium dihydrogen phosphate, sodium citrate, and sulfuric acid by adding each chemical to a 100 mL volumetric flask and filling to the mark with 18-ohm water.…”

Section: Inhalation Pathwaymentioning

confidence: 99%

Assessment of the geoavailability of trace elements from minerals in mine wastes: analytical techniques and assessment of selected copper minerals

Driscoll¹,

Hageman²,

Benzel³

et al. 2012

Scientific Investigations Report

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“…Très tôt des tests de solubilité in vitro ont été développés (Kanapilly et al, 1973 ;Cooke et Holt, 1974 ;Eidson, 1994) utilisant pour la plupart des solutions simulant la composition chimique des liquides extracellulaires décrits par Gamble (1967). Toutefois, l'universalité de cette méthode est parfois mise en défaut compte tenu de la méthodologie appliquée (Fleischer, 1975 ;Carter, 1995).…”

Section: La Nature Des éTudes En Radiotoxicologieunclassified

Mieux connaître le devenir biologique des futurs matériaux nucléaires, une nécessité pour maintenir un bon niveau de radioprotection

Métivier¹,

Guillaumont

2007

Radioprotection

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RésuméUn important programme de recherches, appelé « Generation IV », est actuellement développé au niveau international pour préparer les réacteurs du futur et leurs AbstractTo better know the biological behaviour of future nuclear materials: a need to maintain a good level of protection against ionising radiation.An important program of research, called "Generation IV" is currently developed at an international level to prepare the launching of reactors for the future. Its objective is to satisfy the growing needs in electric power within the framework for a sustainable development. One of the major aspects of this program is the search and the development for new nuclear materials containing fissile/fertile isotopes. Unfortunately, one realizes today that for many compounds considered to be used to manufacture these materials, there are no radiotoxicologic data, allowing to the occupational physicist to evaluate the real risk in the event of contaminations and to prescribe adapted therapeutic de-corporation. An emergency revival of "workplace" studies, where are or will be handled these compounds or materials is mandatory. The lesson of the past showed that the prevision in radioprotection was rather difficult and that an experimental validation of the behaviour of hazardous heavy elements both in vitro and in vivo was necessary.Keywords: nuclear fuels / generation IV / internal dosimetry / biokinetics / DPUI 1 2 allée des Hautes Futaies, 91450 Soisy-sur-Seine, France. 2 Membre de l'Académie des sciences, 7 rue E. Branly, 91120 Palaiseau, France.Article published by EDP Sciences and available at http://www.edpsciences.org/radiopro or http://dx

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Measurement of in Vitro Dissolution of Aerosol Particles for Comparison to in Vivo Dissolution in the Lower Respiratory Tract after Inhalation

Cited by 94 publications

References 0 publications

In vitro chemical and cellular tests applied to uranium trioxide with different hydration states.

In vitro chemical and cellular tests applied to uranium trioxide with different hydration states.

Assessment of the geoavailability of trace elements from minerals in mine wastes: analytical techniques and assessment of selected copper minerals

Mieux connaître le devenir biologique des futurs matériaux nucléaires, une nécessité pour maintenir un bon niveau de radioprotection

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