Measurement of Impedimetric Ratio of Blood Cells Using Microfluidic Chip with ZnO Nanowires

Weng, Kuo Yi; Chang, Yaw Jen; Ho, Ching Yuan; Liou, De Ue; Huang, Yu; Chung, Wen Yaw; Chin, Ting‐Yu

doi:10.1007/s40846-017-0333-2

Cited by 6 publications

(4 citation statements)

References 31 publications

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“…Other studies include membrane-based microfluidics for separation [190], effects of osmolality and perfusion on erythrocyte rheology [191], enhanced deposition analysis of sickle cell RBCs [192], and studies on RBC capillary velocities as a function of oxygen content [98]. Electro mechanic experiments include observing rabbit RBCs in optofluidic tweezers and stretchers [193], impedimetric ratio measurements via microfluidic chips and ZnO nanowires [194], blood platelet enrichment methods via surface acoustic wave (SAW) microchannel platforms [195], and MOSFET-based microfluidic gates [196].…”

Section: Miscellaneous Observationsmentioning

confidence: 99%

Advances in Microfluidics for Single Red Blood Cell Analysis

et al. 2023

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The utilizations of microfluidic chips for single RBC (red blood cell) studies have attracted great interests in recent years to filter, trap, analyze, and release single erythrocytes for various applications. Researchers in this field have highlighted the vast potential in developing micro devices for industrial and academia usages, including lab-on-a-chip and organ-on-a-chip systems. This article critically reviews the current state-of-the-art and recent advances of microfluidics for single RBC analyses, including integrated sensors and microfluidic platforms for microscopic/tomographic/spectroscopic single RBC analyses, trapping arrays (including bifurcating channels), dielectrophoretic and agglutination/aggregation studies, as well as clinical implications covering cancer, sepsis, prenatal, and Sickle Cell diseases. Microfluidics based RBC microarrays, sorting/counting and trapping techniques (including acoustic, dielectrophoretic, hydrodynamic, magnetic, and optical techniques) are also reviewed. Lastly, organs on chips, multi-organ chips, and drug discovery involving single RBC are described. The limitations and drawbacks of each technology are addressed and future prospects are discussed.

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Section: Miscellaneous Observationsmentioning

confidence: 99%

Advances in Microfluidics for Single Red Blood Cell Analysis

et al. 2023

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“…These features make microfluidics-ZnO a promising platform for electrochemical sensing of targets such as pH, 53,94 biomolecules, 72,87,92,93,97 gas molecules, 65 and blood. 94,98 Since ZnO is an n-type semiconductor whose surface electron charge could be changed by the surrounding ion charge concentration, this change of surface charge causes electrical conductance modulation at different pH levels and thus allows for pH sensing. It was found that, due to the formation of a depletion layer at the surface, the conductance of the ZnO nanowire array decreases as the pH level is increased.…”

Section: Electrochemical Sensingmentioning

confidence: 99%

“…8B). 98 In addition, based on programmable temperature control and parallel chemical supply within a microfluidic platform, heterogeneous nanomaterial arrays containing ZnO were developed as multiplexed gas sensors for sub-ppm NO 2 and tens of ppm CO gas detection. 65 Similarly, ZnO-based PDMS and paper microfluidic chips have been widely applied for the sensing detection of various biomolecules, such as thyrotropin, 87 glucose, 92 IgG, 93 HIV p24 antigen, 93 amino acids (L-glutamic acid and L-cysteine), 97 and influenza viruses (H1N1, H5N1, and H7N9).…”

Section: Biomaterials Science Reviewmentioning

confidence: 99%

Microfluidics for ZnO micro-/nanomaterials development: rational design, controllable synthesis, and on-chip bioapplications

Hao

Zhang

2020

Biomater. Sci.

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“…Recently, some microfluidic electrochemical biosensors were reported for biochemical analysis, which offered shorter detection time, less sample and reagent consumption, automatic operation, and less cross-contamination ( Li et al., 2018 , Nguyen et al., 2018 , Singh et al., 2018 , Soares et al., 2018 , Wang et al., 2018 ). In these microfluidic biosensors, the biological recognition elements were generally immobilized on the surface of the electrodes ( Pursey et al., 2017 , Singh et al., 2017 , Weng et al., 2017 , Ghrera et al., 2018 ), which could capture the targets or enhance the signals resulting in more impedance changes on the electrode–solution interface. However, their reproducibility was often unsatisfied due to the complicated electrode modification procedures, and the binding efficiency was often relatively low due to solid-liquid phase reaction, which limited their practical applications.…”

Section: Introductionmentioning

confidence: 99%

Combining impedance biosensor with immunomagnetic separation for rapid screening of Salmonella in poultry supply chains

Wang

Guo

et al. 2020

Poultry Science

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Salmonella screening is a key to ensure food safety in poultry supply chains. Currently available Salmonella detection methods including culture, polymerase chain reaction and enzyme-linked immuno-sorbent assay could not achieve rapid, sensitive, and in-field detection. In this study, different strategies for separation and detection of Salmonella were proposed, compared, and improved based on our previous studies on immunomagnetic separation and impedance biosensor. First, the coaxial capillary for immunomagnetic separation of target bacteria was improved with less contamination, and 3 strategies based on the improved capillary and immunomagnetic nanoparticles were compared to separate the target bacteria from sample and form the magnetic bacteria. The experimental results showed that the strategy of capture in tube and separation in capillary was the most suitable with separation efficiency of approximately 88%. Then, the immune gold nanoparticles coated with urease were used to label the magnetic bacteria, resulting in the formation of enzymatic bacteria, which were injected into the capillary. After the urea was catalyzed by the urease on the enzymatic bacteria in the capillary, different electrodes were compared to measure the impedance of the catalysate and the screen-printed electrode with higher sensitivity and better stability was the most suitable. This impedance biosensor-based bacterial detection strategy was able to detect Salmonella as low as 10 2 CFU/mL in 2 h without complex operations. Compared to the gold standard culture method for practical screening of Salmonella in poultry supply chains, this proposed strategy had an accuracy of approximately 90% for 75 real poultry samples.

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Measurement of Impedimetric Ratio of Blood Cells Using Microfluidic Chip with ZnO Nanowires

Cited by 6 publications

References 31 publications

Advances in Microfluidics for Single Red Blood Cell Analysis

Advances in Microfluidics for Single Red Blood Cell Analysis

Microfluidics for ZnO micro-/nanomaterials development: rational design, controllable synthesis, and on-chip bioapplications

Combining impedance biosensor with immunomagnetic separation for rapid screening of Salmonella in poultry supply chains

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