Measurement of IgE to pollen allergen components is helpful in selecting patients for immunotherapy

Letrán, Antonio; Espinazo, Marisa; Moreno, Francisco

doi:10.1016/j.anai.2013.07.005

Cited by 41 publications

(28 citation statements)

References 7 publications

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“…In the last decade, the gradual development of specific immunological and molecular biology techniques has allowed us to reach a more accurate diagnosis through the identification of allergenic components (molecular diagnosis) 1, 2, 3, 4 and it has also helped to develop AIT treatments with a precise allergen content and, therefore, more effective and safer. Beyond the progress in diagnosis, the publication of European guidelines 5 defining the methodology for clinical trials has allowed investigators to better demonstrate the value of the AIT supported by evidence‐based medicine 6.…”

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confidence: 99%

Variation in allergen content in sublingual allergen immunotherapy with house dust mites

Benítez

Espinazo-Romeu

Camacho

et al. 2015

Allergy

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BackgroundAllergen immunotherapy is a treatment modality which can be applied using different vaccines. The aim of this study was to quantify and compare the allergen content of different house dust mites (HDM)’ sublingual treatments and to review the evidence on their efficacy.MethodsFive sublingual allergen immunotherapy (SLIT) products were ordered and purchased at an ordinary pharmacy and masked for blinding before the study was started. Detection of Dermatophagoides pteronyssinus and Dermatophagoides farinae allergens Der p 1, Der f 1, Der p 2 and Der f 2 was carried out by immunoblotting and fluorescent multiplex. A literature search for meta‐analyses and systematic reviews that included SLIT‐HDM products was performed.ResultsDer p 1 concentrations ranged from 0.6 to 14.5 μg/ml; similar figures were found for Der f 1 that ranged from 0.2 to 12.4 μg/ml. Der p 2+ Der f 2 ranged from 0.2 to 1.5 μg/ml. Data on efficacy are scarce for most of the five products.ConclusionsSubstantial variations regarding allergen content were found among these five SLIT‐HDM products. Therefore, it can be necessary to guarantee the quality of the SLIT‐HDM products and to demonstrate their effectiveness before they are marketed. It seems necessary, for the moment, to take into account these characteristics of the products before prescribing.

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mentioning

confidence: 99%

Variation in allergen content in sublingual allergen immunotherapy with house dust mites

Benítez

Espinazo-Romeu

Camacho

et al. 2015

Allergy

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“…Висновком цих досліджень було те, що важливість пилку ясеня як причини сенсибілізації була недооцінена і, в першу чергу, через нашарування періодів полінації з бере-зою. На сході Австрії, серед 5416 пацієнтів сенси-білізованих до різноманітного пилку, приблизно у 17,6 % виявлені позитивні шкірні тести до ясеня [29]. У Кордобі (Іспанія) проводили SPT екстрактом пилку ясеня 1500 пацієнтам з пилковою алергією і в 59 % осіб вони були позитивними, причому у 8 % була моносенсибілізація [30].…”

Section: обговорення результатів дослідженняunclassified

Analysis of the effectiveness of allergoimmunotherapy in patients with allergies to pollen of spring trees

Зубченко¹,

Chopyak²,

Yuriev³

et al. 2017

ScienceRise: Medical Science

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“…Aufgrund der Speziesspezifität der jeweiligen Majorallergene erlaubt die Umsetzung einer an die regionalen Gegebenheiten angepassten Komponenten-aufgelösten Diagnostik die Korrektur der schon aufgrund von Hauttests getroffenen Therapieentscheidung [16], indem das individuelle Sensibilisierungsmuster der Patienten auf nOle e 1, rPhl p 1 + 5b, die Minorallergene rPhl p 12 und 7 sowie das Pru p 3, Markerallergen für Lipidtransferproteine (LTP), die mit klinischen Symptomen besonders im Mittelmeerraum assoziiert sind, untersucht wurde. Während die Majorallergene es ermöglichten, die Primärsensibilisierung zu detektieren, erwiesen sich Minorallergene und LTP hier als wenig hilfreich.…”

Section: Gräserpollenallergieunclassified

Molekular-allergologische Aspekte der allergenspezifischen Immuntherapie

Jappe

2017

Hautarzt

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Allergen-specific immunotherapy (SIT) does not achieve 100% efficacy, nor is there a reliable marker for therapy failure. However, advances in molecular allergology over the past few years have allowed a significantly improved characterization of the patients using molecular-allergological analysis methods (molecular phenotyping). Thus, major and minor allergens can be identified. In addition, the marker allergens for the severity of an allergic reaction, the pathological and therapeutic predictive marker allergens, and sensitization patterns are identified.

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Measurement of IgE to pollen allergen components is helpful in selecting patients for immunotherapy

Cited by 41 publications

References 7 publications

Variation in allergen content in sublingual allergen immunotherapy with house dust mites

Variation in allergen content in sublingual allergen immunotherapy with house dust mites

Analysis of the effectiveness of allergoimmunotherapy in patients with allergies to pollen of spring trees

Molekular-allergologische Aspekte der allergenspezifischen Immuntherapie

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