Measurement of Glomerular Filtration Rate By Low-Dose Iopromide Plasma Clearance

Hackstein, Nils; Wiegand, Cornelia; Langheinrich, Alexander C.; Rau, W. S.

doi:10.1034/j.1600-0455.2003.00037.x

Cited by 7 publications

(2 citation statements)

References 16 publications

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“…Twenty‐three patients received an injection of 12 mL of iopromide, 300 mg of iodine/mL/75 kg of body weight immediately after a plain MRI examination. As described in earlier studies (13–15), plasma clearance of iopromide was then calculated from three plasma probes withdrawn three, four, and five hours after injection.…”

Section: Methodsmentioning

confidence: 99%

Measurement of single‐kidney glomerular filtration rate using a contrast‐enhanced dynamic gradient‐echo sequence and the Rutland‐Patlak plot technique

Hackstein

Heckrodt

Rau

2003

Magnetic Resonance Imaging

148

140

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Purpose:To determine the accuracy of single-kidney glomerular filtration rate (GFR) determination using contrastenhanced dynamic magnetic resonance imaging (MRI) and the Rutland-Patlak plot technique. Materials and Methods:Twenty-eight adult patients were included. As reference method, the GFR was measured by plasma clearance using a small bolus injection of iopromide. A three-dimensional gradient-echo (GRE) sequence with a flip angle of 50°was used for MRI; this showed a good linear relationship between gadolinium (Gd)-DTPA concentration and signal change when measured up to a Gd-DTPA concentration of 10 mmol/liter. A slab containing both kidneys and the abdominal aorta was measured 30 times in approximately 3.5 minutes. During this measurement, 15 mL of Gd-DTPA, 0.5 mol/liter diluted to a volume of 60 mL, was injected over 60 seconds. A Rutland-Patlak plot was calculated from the signal changes in the aorta and the renal parenchyma. Single-kidney GFR was calculated for different time windows from the Rutland-Patlak plot slope. Results:The best correlation compared to the reference method was found with the GFR calculated from the slope of the Rutland-Patlak plot 40 -110 seconds postaortic rise. Pearson's correlation coefficient was r ϭ 0.86, SD was 14.8 mL/minute. In many of the patients, a decrease of the renal signal was observed in the excretory phase, which was probably caused by very high Gd-DTPA concentrations in the collecting tubules. Conclusion:Single-kidney GFR can be calculated from dynamic contrast-enhanced MRI. We found a promising correlation of global GFR calculated by MRI compared to the reference method. In any future study, the amount of Gd-DTPA should by reduced to avoid artificial signal drop in the excretory phase induced by the T2* effect.

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Section: Methodsmentioning

confidence: 99%

Measurement of single‐kidney glomerular filtration rate using a contrast‐enhanced dynamic gradient‐echo sequence and the Rutland‐Patlak plot technique

Hackstein

Heckrodt

Rau

2003

Magnetic Resonance Imaging

148

140

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show abstract

“…By measuring the weight difference of the syringe before and after injection, and by measuring the iodine concentration in three plasma samples withdrawn 3, 4, and 5 hours after injection, the plasma GFR was calculated. The method and the formulas used were described in detail in a previous article (8). As reference value, we calculated the mean of the four iopromide plasma measurements from the four study days, which is hereinafter termed the "GFR(ref).…”

Section: Gfr Reference Methodsmentioning

confidence: 99%

Glomerular filtration rate measured using the Patlak plot technique and contrast‐enhanced dynamic MRI with different amounts of gadolinium‐DTPA

Hackstein

Kooijman

Tomaselli

et al. 2005

Magnetic Resonance Imaging

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We determined the optimum gadolinium (Gd)-DTPA dose and time window for calculating the glomerular filtration rate (GFR) using contrast-enhanced (CE) dynamic MRI and the Patlak plot technique. Twelve adult volunteers with healthy kidneys were included in the study. As a reference method the GFR was measured by iopromide plasma clearance. A three-dimensional gradient-echo (GRE) sequence with a flip angle of 50°was used for MRI. Signal was measured using a body surface coil with four elements. Each volunteer was examined on four days using 2 mL, 4 mL, 8 mL, or 16 mL of Gd-DTPA 0.5 mmol/mL dissolved with sodium chloride (NaCl) 0.9% to a total of 60 mL. The injection rate was 1 mL/second. A Patlak plot was calculated from the kidney and aorta signals. The mean reference GFR was 133 mL/min (min-max, 116 -153 mL/min). The best correlation of GFR calculated from MRI data compared to the reference method was found in a time window 30 -90 seconds after aortic signal rise using 16 mL Gd-DTPA. Pearson's correlation coefficient was r ϭ 0.83, and the standard deviation (SD) from the line of regression was 10.5 mL/minute. We found a significantly lower average GFR(MR) using 16 mL Gd-DTPA compared to 4 mL and 2 mL in the late time window 60 -120 seconds post aortic rise. A dose of 16 mL Gd-DTPA was optimal for measuring GFR using dynamic MRI and the Patlak plot technique. The slope should be measured in a time window of 30 -90 seconds post aortic rise.

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Determination of single-kidney glomerular filtration rate (GFR) with CT urography versus renal dynamic imaging Gates method

You

Zhang

et al. 2017

Eur Radiol

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Measurement of Glomerular Filtration Rate By Low-Dose Iopromide Plasma Clearance

Abstract: Plasma clearance of iopromide is dose-independent on use of iodine amounts of 3.6 g and 36 g I/75 kg b.w. The GFR can be determined by high-dose and low-dose iopromide plasma clearance with identical accuracy.

Cited by 7 publications

References 16 publications

Measurement of single‐kidney glomerular filtration rate using a contrast‐enhanced dynamic gradient‐echo sequence and the Rutland‐Patlak plot technique

Measurement of single‐kidney glomerular filtration rate using a contrast‐enhanced dynamic gradient‐echo sequence and the Rutland‐Patlak plot technique

Glomerular filtration rate measured using the Patlak plot technique and contrast‐enhanced dynamic MRI with different amounts of gadolinium‐DTPA

Determination of single-kidney glomerular filtration rate (GFR) with CT urography versus renal dynamic imaging Gates method

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