“…At the same time, recent work has also attempted to link transcription factor localization and binding to transcription. Using cutting edge microscopy (Elf et al, 2007; Hammar et al, 2012) and probing technology (Shah and Tyagi, 2013), efforts to relate the binding of transcription factors to transcription itself are just now shedding light on these relationships (Larson et al, 2011b; Sepúlveda et al, 2016; Shah and Tyagi, 2013; Xu et al, 2015), and single cell reporters of methylation are on the horizon as well (Stelzer et al, 2015). The advent of genome-wide techniques for measuring transcription factor binding provide a glimpse of what the future holds in this regard (Buenrostro et al, 2015; Cusanovich et al, 2015).…”