Measurement of exercise cardiac output by thoracic impedance in healthy children

Pianosi, Paul

doi:10.1007/s00421-004-1167-5

Cited by 13 publications

(13 citation statements)

References 21 publications

(30 reference statements)

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“…The slope of the CO-_ V O 2 equation describes the rate of change between the two variables with increasing levels of _ V O 2 In studies with children values at maximal exercise of 4.50 and 6.98 have been reported for Doppler determinations (Rowland et al 1997;Nottin et al 2001) and 6.72 for CO 2 rebreathing in a mixed sample of boys and girls . Previous studies using traditional impedance methods with children identified slopes of 4.6 (Pianosi and Garros 1996;Rowland and Popowski 1996) and 5.2 (Pianosi 2004). Thus the value of 6.3 identified in the present study falls within the range reported from previous studies using a variety of techniques.…”

Section: Discussionsupporting

confidence: 82%

Reliability of peak $$\dot V{\text{O}}_2 $$ and maximal cardiac output assessed using thoracic bioimpedance in children

et al. 2005

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The purpose of this study was to evaluate the reliability of a thoracic electrical bioimpedance based device (PhysioFlow) for the determination of cardiac output and stroke volume during exercise at peak oxygen uptake (peak VO(2) in children. The reliability of peak VO(2) is also reported. Eleven boys and nine girls aged 10-11 years completed a cycle ergometer test to voluntary exhaustion on three occasions each 1 week apart. Peak VO(2) was determined and cardiac output and stroke volume at peak VO(2) were measured using a thoracic bioelectrical impedance device (PhysioFlow). The reliability of peak VO(2) cardiac output and stroke volume were determined initially from pairwise comparisons and subsequently across all three trials analysed together through calculation of typical error and intraclass correlation. The pairwise comparisons revealed no consistent bias across tests for all three measures and there was no evidence of non-uniform errors (heteroscedasticity). When three trials were analysed together typical error expressed as a coefficient of variation was 4.1% for peak VO(2) 9.3% for cardiac output and 9.3% for stroke volume. Results analysed by sex revealed no consistent differences. The PhysioFlow method allows non-invasive, beat-to-beat determination of cardiac output and stroke volume which is feasible for measurements during maximal exercise in children. The reliability of the PhysioFlow falls between that demonstrated for Doppler echocardiography (5%) and CO(2) rebreathing (12%) at maximal exercise but combines the significant advantages of portability, lower expense and requires less technical expertise to obtain reliable results.

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Section: Discussionsupporting

confidence: 82%

Reliability of peak $$\dot V{\text{O}}_2 $$ and maximal cardiac output assessed using thoracic bioimpedance in children

et al. 2005

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“…To collect saliva during the exercise test implies that the exercise test would have had to be interrupted, and this in itself could have implications for the results. The decrease in salivary cortisol levels after the exercise tests may be explained by an increase in circulating blood volume compared with a relative low production rate of cortisol, as has been suggested (33,34) . A certain exercise Brought to you by | University of California -San Francisco Authenticated Download Date | 2/18/15 5:18 PM intensity is needed to increase hypothalamic-pituitary-adrenocortical axis activity probably by changes in plasma lactate levels.…”

Section: Discussionmentioning

confidence: 88%

Non-invasive measurement of adrenal response after standardized exercise tests in prepubertal children

Heijsman

Koers

Bocca³

et al. 2012

Journal of Pediatric Endocrinology and Metabolism

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Objective:To determine the feasibility of non-invasive evaluation of adrenal response in healthy prepubertal children by standardized exercise tests. Methods: On separate occasions, healthy prepubertal children performed a submaximal cycling test, a maximal cycling test, and a 20-m shuttle-run test. Salivary cortisol levels were determined before exercise, and 1 and 15 min after exercise. Results: Immediately after cessation of the cycling and shuttle-run tests, salivary cortisol levels remained unchanged or decreased. Fifteen minutes after the shuttle-run test, salivary cortisol levels increased signifi cantly. This increase in salivary cortisol levels was not observed 15 min after the cessation of the cycling tests. Conclusion:The results of this study demonstrate a different response in salivary cortisol levels after standardized cycling and running tests in prepubertal children. The increase in salivary cortisol levels found after a short standardized running test suggests that this may be a practical non-invasive method for evaluating adrenal response in healthy prepubertal children.

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“…Indeed, impedance cardiography revealed that cardiac output increased mainly by an increase in heart rate (59%) with minimal change in stroke volume (17%). Previous studies have shown that during maximal exercise in children, SV increases approximately 30% over resting values (39, 40). The decreased change in SV observed in this study may represent a limitation affecting exercise cardiac performance.…”

Section: Discussionmentioning

confidence: 95%

Exercise Capacity and Idebenone Intervention in Children and Adolescents With Friedreich Ataxia

Drinkard

Keyser

Paul

et al. 2010

Archives of Physical Medicine and Rehabilitation

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Objective To determine the effects of idebenone on exercise capacity in children and adolescents with Friedreich’s Ataxia. Design Secondary analysis of a randomized double-blind, placebo controlled, phase II clinical trial. Setting Clinical research center, exercise physiology laboratory. Participants 42 subjects (ages 9–17) with genetically confirmed FA. Intervention Six-month idebenone regimens of approximately 5, 15, and 45 mg/kg/day or placebo. Main Outcome Variables Peak oxygen consumption (peak VO2) and peak work rate (WR) were measured during incremental exercise tests before and after treatment. Echocardiography and neurological assessments were also completed before and after theidebenone regimen. Results Baseline peak VO2 was 746+246 ml/min (16.2 ± 5.8 ml/kg/min) and WR was 40+23 watts in all subjects combined. Peak VO2 and WR were correlated with short GAA repeat length and neurological assessments. Relative left ventricular wall thickness (RWT) was increased but left ventricular ejection fraction was normal in the majority of subjects; there was no relationship between any exercise and echocardiographic measure. There were no significant changes in peak VO2 or WR after idebenone treatment. Conclusions Exercise capacity was severely impaired in these children and adolescents with FA and after 6 months of idebenone treatment did not change by an amount thought to be clinically relevant.

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Measurement of exercise cardiac output by thoracic impedance in healthy children

Cited by 13 publications

References 21 publications

Reliability of peak $$\dot V{\text{O}}_2 $$ and maximal cardiac output assessed using thoracic bioimpedance in children

Reliability of peak $$\dot V{\text{O}}_2 $$ and maximal cardiac output assessed using thoracic bioimpedance in children

Non-invasive measurement of adrenal response after standardized exercise tests in prepubertal children

Exercise Capacity and Idebenone Intervention in Children and Adolescents With Friedreich Ataxia

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