“…The primary effect of Gd is the shortening of the spinlattice relaxation time T1, resulting in greater signal in T1-weighted images. For low concentrations (C) of the contrast medium, the change in relaxation rate R 1 (= 1=T 1 ) is proportional to C, i.e., R c 1 0 R 1 / C (1) where R c 1 and R 1 are, respectively, the postcontrast and precontrast relaxation rates [4]. If the changes in T1 values can be accurately measured as a function of time (t), an important task in DCE MRI is to further deduce C(t), from which physiological variables associated with tumor microcirculation can be estimated by tracer kinetic modeling [5].…”