Measurement of electrical activity of long-term mammalian neuronal networks on semiconductor neurosensor chips and comparison with conventional microelectrode arrays

Physiological consequences of selective suppression of synaptic transmission in developing cerebral cortical networks in vitro: Differential effects on intrinsically generated bioelectric discharges in a living ‘model’ system for slow-wave sleep activity

“…Little would be gained with respect to such parameters by sampling more than a single point in a given preparation. Much of the interindividual variance in other variables measured, however, is an expression of regional differences within each explant, as is readily ascertainable by recording either sequentially (see Baker et al, 2006;Crain, 1976) or from several electrodes simultaneously (e.g., Plenz, 2003, 2004;Bettencourt et al, 2007;Chao et al, 2007;Droge et al, 1986;Giugliano et al, 2004;Jimbo and Robinson, 2000;Krause et al, 2006;Madhavan et al, 2007;Potter and DeMarse, 2001;Rolston et al, 2007;Wagenaar et al, 2006a,b). Thus, the mean duration, intensity and oscillatory character of a midi-or maxi-burst tends to be unpredictably site-specific, even in mega-co-cultures , thus giving each age and treatment group an irreducibly large variance with regard to those parameters (Echevarria and Albus, 2000;Pinato et al, 1999;Wagenaar et al, 2006a).…”

Fabrication and characterization of implantable silicon neural probe with microfluidic channels

“…In this paper the technology of trench refill combined with parylene-C was used to fabricate the probe with microfluidic channel. Parylene C has good biocompatibility, outstanding moisture barrier, excellent chemical inert, and extremely high dielectric strength [15]. Moreover, compared with silicon nitride and silicon oxide used to refill the holes, parylene-C has lower deposition temperature and lower stress.…”

New insights into the nanometer-scaled cell-surface interspace by cell-sensor measurements

“…This circumstance has to be considered not only as far as cell-sensor contacts are concerned but is important for all cells adhering to substrates. Why are only some cells able to grow on petri dishes and why, when working with Neuro-chip to monitor action-potentials, electrodes give better signals than FETs (field-effect transistors) are open questions [31], where this work has to be considered and could add a puzzle.…”