Measurement of deep gray matter perfusion using a segmented true–fast imaging with steady‐state precession (True‐FISP) arterial spin‐labeling (ASL) method at 3T

Grossman, Elan J.; Zhang, Ke; An, Jing; Voorhees, Abram; Inglese, Matilde; Ge, Yulin; Oesingmann, Niels; Xu, Jian; McGorty, Kelly Anne; Chen, Qun

doi:10.1002/jmri.21794

Cited by 14 publications

(17 citation statements)

References 34 publications

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“…This is especially the case at higher fields, such that EPI at the basal ganglia level can be particularly challenging due to an increased iron component. Therefore, in this study we have used True FISP ASL [25], a non-EPI based method of ASL preparation which is a particularly attractive method of measuring local tissue perfusion in cerebral deep gray matter with high spatial resolution and without the distortion artifacts commonly associated with EPI based techniques [26]. …”

Section: Discussionmentioning

confidence: 99%

“…However, in true FISP ASL [25], a flow-sensitive alternating inversion recovery (FAIR) ASL [29] perfusion preparation is used in which the EPI sequence is replaced with a true FISP steady state precession data acquisition strategy. The benefits of such a sequence include high spatial resolution images with none of the distortion artifacts commonly associated with EPI based methods of ASL [26]. …”

Section: Methodsmentioning

confidence: 99%

“…In the current work true fast imaging with steady state precession arterial spin labeling (true FISP ASL) [25] was employed for the measurement and quantification of local cerebral perfusion. True FISP ASL is an MRI method of investigating CBF that uses blood water as an endogenous, freely diffusible tracer and yields high resolution images without distortion artifacts or the need for exogenous endovascular contrast agents [26]. …”

Section: Introductionmentioning

confidence: 99%

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Assessment of thalamic perfusion in patients with mild traumatic brain injury by true FISP arterial spin labelling MR imaging at 3T

et al. 2009

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Functional blood flow abnormalities after brain injury have been demonstrated in animal models of head trauma and are considered to contribute to post concussive syndrome (PCS). In order to better characterize cerebral blood flow (CBF) changes and PCS in patients with mild traumatic brain injury (MTBI), we determined CBF in different brain regions using a true fast imaging with steady state precession arterial spin labeling (True FISP ASL) imaging at 3T. We also investigated the severity of neuropsychological functional impairment with respect to hemodynamic changes. Twenty-one patients with clinically diagnosed MTBI and 18 healthy age-matched controls were studied. The median time since the onset of brain injury in patients was 26.5 months. True FISP ASL MRI was performed at 3T MR in which a flow-sensitive alternating inversion recovery (FAIR) preparation was applied. Measurements of regional CBF were made in both deep gray matter including thalamus and white matter at the basal ganglia level. The mean regional CBF was reduced and more significantly in both sides of thalamus in patients with MTBI (45.9±9.8ml/100g/min) as compared to normal controls (57.4±10.3ml/100g/min; p=0.002). The decrease of thalamic CBF was significantly correlated with several computerized neuropsychological measures including processing and response speed, memory, verbal fluency, and executive function in patients with MTBI. These results indicate that hemodynamic impairment can occur and persist in patients with MTBI, the extent of which is more severe in thalamic regions and correlate with neuropsychological impairment during the extended course of the disease.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of thalamic perfusion in patients with mild traumatic brain injury by true FISP arterial spin labelling MR imaging at 3T

et al. 2009

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“…4,6,12-14 In a previous cross-sectional study, 6 we applied segmented true fast imaging with steady-state precession ASL 21 to the investigation of patients with MTBI, a newly developed MR imaging technique that uses blood water as an endogenous freely diffusible tracer that can provide CBF measurements in the thalamus and deep gray matter while excluding susceptibility artifacts commonly associated with these regions in other similar approaches to data acquisition. Results demonstrated that in patients with MTBI, CBF in the thalamus was decreased and was associated with neuropsychological performance.…”

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confidence: 99%

Cognitive Impairment in Mild Traumatic Brain Injury: A Longitudinal Diffusional Kurtosis and Perfusion Imaging Study

Grossman

Jensen

Babb³

et al. 2012

AJNR Am J Neuroradiol

167

134

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BACKGROUND AND PURPOSE Cognitive impairment is frequent among patients with mild traumatic brain injury despite the absence of detectable damage on conventional MR imaging. In this study, the quantitative MR imaging techniques DTI, DKI, and ASL were used to measure changes in the structure and function in the thalamus and WM of patients with MTBI during a short follow-up period, to determine whether these techniques can be used to investigate relationships with cognitive performance and to predict outcome. MATERIALS AND METHODS Twenty patients with MTBI and 16 controls underwent MR imaging at 3T and a neuropsychological battery designed to yield measures for attention, concentration, executive functioning, memory, learning, and information processing. MK, FA, MD, and CBF were measured in the thalamus by using region-of-interest analysis and in WM by using tract-based spatial statistics. Analyses were performed comparing regional imaging measures of subject groups and the results of testing of their associations with neuropsychological performance. RESULTS Patients with MTBI exhibited significant differences from controls for DTI, DKI, and ASL measures in the thalamus and various WM regions both within 1 month after injury and >9 months after injury. At baseline, DTI and DKI measures in the thalamus and various WM regions were significantly associated with performance in different neuropsychological domains, and cognitive impairment was significantly associated with MK in the thalamus and FA in optic radiations. CONCLUSIONS Combined application of DTI, DKI, and ASL to study MTBI might be useful for investigating dynamic changes in the thalamus and WM as well as cognitive impairment during a short follow-up period, though the small number of patients examined did not predict outcome.

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“…With the use of fast imaging sequences and higher magnetic field strengths, ASL acquisitions with in-plane resolutions of 1-2 mm (and 5-8 mm slice thickness) have been demonstrated (Grossman et al, 2009;Zuo et al, 2013). To improve SNR, the through-plane resolution is often chosen to be slightly larger than the in-plane resolution (e.g., 3 Â 3 mm in-plane resolution with a 5 mm slice thickness).…”

Section: Image Acquisitionmentioning

confidence: 99%

Perfusion Imaging with Arterial Spin Labeling MRI

Liu

2015

Brain Mapping

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Measurement of deep gray matter perfusion using a segmented true–fast imaging with steady‐state precession (True‐FISP) arterial spin‐labeling (ASL) method at 3T

Cited by 14 publications

References 34 publications

Assessment of thalamic perfusion in patients with mild traumatic brain injury by true FISP arterial spin labelling MR imaging at 3T

Assessment of thalamic perfusion in patients with mild traumatic brain injury by true FISP arterial spin labelling MR imaging at 3T

Cognitive Impairment in Mild Traumatic Brain Injury: A Longitudinal Diffusional Kurtosis and Perfusion Imaging Study

Perfusion Imaging with Arterial Spin Labeling MRI

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