Measurement of Colonic Mucosal Concentrations of 5-Aminosalicylic Acid Is Useful for Estimating Its Therapeutic Efficacy in Distal Ulcerative Colitis: Comparison of Orally Administered Mesalamine and Sulfasalazine

Naganuma, Makoto; Iwao, Yasushi; Ogata, Haruhiko; Inoue, Nagamu; Funakoshi, Shinsuke; Yamamoto, Shojirou; Nakamura, Yuji; Ishii, Hiromasa; Hibi, Toshifumi

doi:10.1097/00054725-200108000-00007

Cited by 86 publications

(70 citation statements)

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“…However, there have been few reports investigating the relationship between colonic mucosal concentrations of 5-ASA and its clinical efficacy. One study showed that tissue concentration of 5-ASA was much higher in patients who received oral and rectal 5-ASA by enema than in patients who had oral 5-ASA alone [65]. These results support the role of rectal 5-ASA as a first-line therapy for mild or moderately active distal UC, and offer guidelines for its use [65,67].…”

Section: Discussionmentioning

confidence: 85%

“…Some studies have shown that clinical and histological remissions are more evident when 5-ASA is administered by enema when compared with oral administration, suggesting that the drug has a topical effect greater than systemic [45,46,65,66]. However, there have been few reports investigating the relationship between colonic mucosal concentrations of 5-ASA and its clinical efficacy.…”

Section: Discussionmentioning

confidence: 99%

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5-Aminosalicylic Acid (5-ASA) Can Reduce Levels of Oxidative DNA Damage in Cells of Colonic Mucosa With and Without Fecal Stream

et al. 2010

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

5-Aminosalicylic Acid (5-ASA) Can Reduce Levels of Oxidative DNA Damage in Cells of Colonic Mucosa With and Without Fecal Stream

et al. 2010

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“…Idiosyncratic side effects such as interstitial nephritis, myocarditis, or pancreatitis are very rare even when oral and systemic forms of 5-ASA are used [19]. The effects of 5-ASA are dependent on the concentration in the colonic mucosa [28]. In Switzerland, a previous report revealed that the consumption rate of topical 5-ASAs was 31.6% compared with the 42.5% for oral 5-ASA [26].…”

Section: Treatmentmentioning

confidence: 99%

Optimized Management of Ulcerative Proctitis: When and How to Use Mesalazine Suppository

et al. 2018

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Background: Ulcerative proctitis, one of the disease types of ulcerative colitis, is considered one of the initial manifestations of ulcerative colitis. Prevention of aggravation of ulcerative proctitis is important for improving the prognosis of ulcerative colitis. Here we reviewed the epidemiology, diagnosis, and management of ulcerative proctitis. Summary: The number of patients with ulcerative proctitis is increasing. Disease extension occurs in many patients with ulcerative proctitis. Differential diagnosis from other chronic proctitis is important and should be performed based on the clinical history and endoscopical and histological features. Mesalazine suppository has been the first-line therapy for patients with ulcerative proctitis because of its high effectiveness and safety. Topical treatment of ulcerative proctitis, particularly using mesalazine suppository has been underused in clinical practice. Key Messages: Mesalazine suppositories are more effective than dose intensification of oral mesalazine for relapsed patients with maintenance dose of oral mesalazine. However, low adherence to rectal mesalazine has hindered remission in patients with ulcerative proctitis.

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“…Bystrowska et al (2000) have performed the determination of 5-ASA in plasma and urine samples Simultaneous assay of 5-aminosalicylic acid and its metabolite 351 ORIGINAL RESEARCH by liquid chromatography following prior derivatization to its acetylated metabolite. Few procedures have been described for the estimation by liquid chromatography of 5-ASA in human ileocolonic biopsy (De Vos et al, 1992;Palumbo et al, 1995;Hussain et al, 1998;Naganuma et al, 2001). Therefore, the objective of this work is to present a one-step liquid-liquid extraction procedure before simultaneous determination of 5-ASA and its metabolite by HPLC in human plasma.…”

Section: Introductionmentioning

confidence: 99%

A validated HPLC method with electrochemical detection for simultaneous assay of 5‐aminosalicylic acid and its metabolite in human plasma

Palumbo

Bacchi

Primavera

et al. 2004

Biomedical Chromatography

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A high-performance liquid chromatographic method was developed, validated and applied to the simultaneous determination of 5-aminosalicylic acid (5-ASA) and its acetylated metabolite (acetyl-5-ASA) in human plasma. The method involves liquid-liquid extraction with methanol followed by isocratic reversed-phase chromatography on a Kromasil KR100 C(18) column with electrochemical detection. The recovery, selectivity, linearity, precision and accuracy of the method were evaluated from spiked human plasma samples. The effects of mobile phase composition, buffer concentration, mobile phase pH and concentration of organic modifiers on retention of 5-ASA, acetyl 5-ASA and internal standard were investigated. Limits' of detection were 5 ng/mL for 5-ASA and 10 ng/mL for acetyl-5-ASA, respectively. The method can be used for supporting therapeutical drug monitoring and pharmacokinetic studies.

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Measurement of Colonic Mucosal Concentrations of 5-Aminosalicylic Acid Is Useful for Estimating Its Therapeutic Efficacy in Distal Ulcerative Colitis: Comparison of Orally Administered Mesalamine and Sulfasalazine

Abstract: We demonstrated that the colonic mucosal concentration of 5-ASA was significantly higher in the sulfasalazine group than in the mesalamine group. Furthermore, the concentrations of mucosal 5-ASA may be a good marker for the estimation of its efficacy in the treatment of ulcerative colitis.

Cited by 86 publications

References 14 publications

5-Aminosalicylic Acid (5-ASA) Can Reduce Levels of Oxidative DNA Damage in Cells of Colonic Mucosa With and Without Fecal Stream

5-Aminosalicylic Acid (5-ASA) Can Reduce Levels of Oxidative DNA Damage in Cells of Colonic Mucosa With and Without Fecal Stream

Optimized Management of Ulcerative Proctitis: When and How to Use Mesalazine Suppository

A validated HPLC method with electrochemical detection for simultaneous assay of 5‐aminosalicylic acid and its metabolite in human plasma

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