Measurement of circulating tumor cells in squamous cell carcinoma of the head and neck and patient outcomes

Morgan, Tiffany; Wang, Xu; Qian, Ximei; Switchenko, Jeffrey M.; Nie, Shuming; Patel, Kirtesh R.; Cassidy, Richard J.; Shin, Dong M.; Beitler, Jonathan J.

doi:10.1007/s12094-018-1930-4

Cited by 15 publications

(10 citation statements)

References 29 publications

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“…The results of the present study are in accordance with other studies investigating CTCs in solid cancers, including the head and neck, which revealed that the presence of CTCs may influence prognosis (11)(12)(13)(14)(15)(16)(17)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57) similar to what was observed in the patients in the present study (6/8 were positive to CTC preoperatively). A recent meta-analysis comprised of 17 studies confirmed the significant prognostic value of CTCs in patients with head and neck cancer, wherein positive CTCs were significantly associated with poor overall, disease-free and progression-free survival (61).…”

Section: Discussionsupporting

confidence: 92%

Detection of circulating tumor cells in patients with laryngeal cancer using ScreenCell: Comparative pre- and post-operative analysis and association with prognosis

et al. 2020

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The presence of circulating tumor cells (CTCs) in the blood of patients with metastatic breast, colorectal and prostate cancer have been widely investigated; however, few studies have examined CTCs in patients with laryngeal cancer. The present pilot study aimed to detect pre-and postoperative CTCs in the blood of patients with laryngeal cancer and evaluate the association with prognosis. Eight patients with laryngeal squamous cell carcinoma (LSCC) at stage III were included in the present study and underwent total or subtotal laryngectomy and radical bilateral neck lymph node dissection. Blood samples were collected from all patients before and after surgery at different time-points. The following processing steps were followed; preoperative blood sampling, surgery, postoperative blood sampling at 3, 6 and 12 month follow-ups, and prognostic association analysis. CTCs were retained on ScreenCell filters for cytological characterization. The presence of CTCs was associated with a less favorable prognosis, whereas a decrease of CTCs in the postoperative sampling was observed in patients who exhibited an improved therapeutic response. The results of the present pilot study revealed a possible association between the presence of CTCs and a less favorable prognosis in patients with LSCC; therefore, these preliminary findings may encourage further research into the incorporation of a liquid biopsy in the management of LSCC, as this may help identify patients with occult metastatic disease earlier and in a non-invasive manner. In addition, this approach may represent novel independent prognostic factor for use in the clinical evaluation of patients with LSCC.

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Section: Discussionsupporting

confidence: 92%

Detection of circulating tumor cells in patients with laryngeal cancer using ScreenCell: Comparative pre- and post-operative analysis and association with prognosis

et al. 2020

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“…Prevention and early detection of distant metastasis are currently the best options available for OSCC. In the near future, analysis of genetic mutations using liquid biopsy samples may allow us to diagnose distant metastasis early during the initial treatment and ensure timely treatment 17 . In other words, conducting regular systematic checkups in patients with OSCC for risk factors for distant metastasis and implementing appropriate drug therapy should be mandatory.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for distant metastasis in locoregionally controlled oral squamous cell carcinoma: a retrospective study

Tomioka

Yamagata

Oikawa

et al. 2021

Sci Rep

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The control of distant metastasis in oral squamous cell carcinoma is an important determinant of improved prognosis. The study aimed to identify risk factors for distant metastasis in patients with locoregionally controlled oral carcinoma. We identified 982 patients with oral squamous cell carcinoma treated at our hospital between January 2008 and December 2017. After excluding patients with distant metastasis at initial treatment, patients with metastasis to the oral cavity, those receiving palliative treatment, and those lacking follow-up data, 941 patients were selected. Finally, among these 941 patients, 887 with locoregionally controlled oral squamous cell carcinoma were included in the study. Among the 887 patients, 36 had confirmed distant metastasis (4.1%), and the lung was the most common site (31/36 patients, 86.1%). Multivariate analysis showed that the incidence of primary intraosseous carcinoma of the mandible, cervical lymph node metastasis at levels IV and V, and the presence of pathological extranodal extension were significant risk factors for distant metastasis. When treating patients with oral squamous cell carcinoma who are positive for the aforementioned risk factors, the possibility of developing distant metastases must be accounted for, and aggressive treatment should be planned accordingly.

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“…In the latest study, Morgan et al used surface-enhanced Raman scattering (SERS) nanotechnology identified amounts of CTCs in HNSCC. 32 They demonstrated that the number of CTCs was correlated with the disease progression of HNSCC patients, and the level of CTCs was a strong indicator of poor prognosis. In this study, we found that PFS and OS of HNSCC patients with CTCs-positive were shorter than those of CTCs-negative patients by survival analysis, which is consistent with most of the previous studies.…”

Section: Discussionmentioning

confidence: 99%

Circulating Tumor Cells Correlate With Prognosis in Head and Neck Squamous Cell Carcinoma

Zhou

Wang

Zhang

et al. 2021

Technol Cancer Res Treat

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Background: To investigate the relationship of circulating tumor cells (CTCs) and the clinical characteristic parameters and prognosis in patients with head and neck squamous cell carcinoma (HNSCC). Methods: The retrospective clinical study included 95 patients with HNSCC who after surgery in Shanghai Ninth People’s Hospital affiliated to Shanghai Jiao Tong University School of Medicine between December 2015 and December 2016. All patients were followed up for survival until the end of June 2019. The CTCs detection was performed by negative enrichment (NE) immunofluorescence-in situ hybridization (im-FISH) of chromosome 8. Results: Patients with higher CTCs counts are associated with a worse prognosis with an area under the receiver operator characteristic (ROC) curve of 0.756 [95% confidence interval (CI) 0.640-0.872, p = 0.001]. The CTCs-positive rate of HNSCC patients was 58.9% (56/95) by using the cut-point of 3. Both the chi-square test and binary logistic regression analysis showed that the N stage and clinical stage were significantly associated with CTCs-positive in patients with HNSCC ( p < 0.05). Further Non-parametric test analysis indicated that more CTCs counts were detected in late N and clinical stages patients ( p < 0.001). The Kaplan-Meier survival analysis indicated that CTCs-positive were correlated with shorter progression-free survival (PFS) ( p < 0.001) and overall survival (OS) ( p = 0.001). Further, the CTCs-positive was an independent prognostic factor for PFS and OS according to the Cox multivariate regression analysis ( p < 0.05). Conclusion: More CTCs were associated with N stage, clinical stage, poor prognosis in patients with HNSCC, which might be used as a prognostic biomarker.

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Measurement of circulating tumor cells in squamous cell carcinoma of the head and neck and patient outcomes

Abstract: Liquid biopsy techniques in HNSCC show promise as a means of identifying patients at greater risk of disease progression.

Cited by 15 publications

References 29 publications

Detection of circulating tumor cells in patients with laryngeal cancer using ScreenCell: Comparative pre- and post-operative analysis and association with prognosis

Detection of circulating tumor cells in patients with laryngeal cancer using ScreenCell: Comparative pre- and post-operative analysis and association with prognosis

Risk factors for distant metastasis in locoregionally controlled oral squamous cell carcinoma: a retrospective study

Circulating Tumor Cells Correlate With Prognosis in Head and Neck Squamous Cell Carcinoma

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