Measurement of changes in vital capacity as a means of detecting pulmonary reactions to inhaled aerosolized allergenic extracts in asthmatic subjects

The allergen bronchoprovocation model: an important tool for the investigation of new asthma anti‐inflammatory therapies

“…The response end point was either exclusively or primarily the EAR. Measurements were initially rather crude and included such things as the development of symptoms, signs (coarse breathing; 25, 26), or changes in maximal breathing capacity and/or vital capacity (27)(28)(29)(30)(31). Technology to measure expiratory flow rates including the forced expiratory volume in 1 s (FEV 1 ) was developed in France in the mid-1940s (31).…”

Aerosol Challenge of Animals

“…Fukui et al 27 reported that virulent Pastaurella pestis cells were cleared much more rapidly from lungs of guinea pigs when ifnhaled as an aerosol tnan when introduced intratracheally. Speck and Wolochow attributed this disparity in LD50 to a difference in the infectious process that was affected to an unknown degree by the challenge route.…”

Immunological aspects of asthma

“…Other evidence in favour of an immunological involvement includes the relationship between the induction of an asthmatic attack and unusual environmental antigens like castor bean (Figley & Elrod, 1928), the close seasonal correlation with grass pollens and the evidence afforded by provocation test with aerosol extracts (Lowell & Schiller, 1948).…”