Measurement of changes in impedance of DNA nanowires due to radiation induced structural damage

Heimbach, Florian; Arndt, Anselm; Nettelbeck, Heidi; Langner, Frank; Giesen, U.; Rabus, Hans; Sellner, Stefan; Toppari, J. Jussi; Shen, Boxuan; Baek, Woon Yong

doi:10.1140/epjd/e2017-70819-1

Cited by 9 publications

(8 citation statements)

References 17 publications

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“…Both approaches imply to some extent a need for revision of the concepts of nanodosimetry [32]. However, this would actually be aligned with the presently most advanced approach to using nanodosimetry for predicting relative biological effectiveness (RBE) in radiotherapy treatment planning, the so-called track-event theory of Besserer and Schneider [34], [35].Although there have also been first approaches applying nanodosimetry with brachytherapy photon sources [36], the first field where nanodosimetry will be used in treatment planning seems to be radiotherapy using protons or ion beams. For the latter, the variation of the RBE is already accounted for in treatment planning [37], while for protons a constant RBE-weighting factor of 1.1 is used and the likely RBE variation is accounted for by considering the so-called biological range uncertainty [38], [39].Several major challenges still have to be mastered before nanodosimetric treatment planning will come into routine clinical practice.…”

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confidence: 99%

Nanodosimetry – on the ''tracks'' of biological radiation effectiveness

Rabus¹

2020

Zeitschrift für Medizinische Physik

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It is well known that the biological effectiveness of a certain absorbed dose of ionizing radiation depends on the radiation quality, i. e. the spectrum of ionizing particles and their energy distribution [1], [2], [3]. As has been shown in several studies, the biological effectiveness is related to the pattern of energy deposits on the microscopic scale, the socalled track structure [4]. Clusters of lesions in the DNA molecule within site sizes of few nanometers play a particular role in this context [4], [5], [6]. A first approach to measure track structure of ionizing radiation with nanometric resolution was proposed already in 1975 [7]. However, the extension of microdosimetric measurements to site sizes of few nanometer dimension was facing the fundamental problem that in such small sites the number of interactions is too low, such that the assumption fails that the imparted energy is the number of ionizations multiplied by a simple conversion factor [8]. Therefore, the development of methods for measuring track structure details with nanometric resolution required a change of paradigm, namely restricting the characterization of track structure to its ionization component [9], [10].In should be noted in this context that the term nanodosimetry is used in the literature in different meanings. These include ongoing endeavors to extend microdosimetry into the nanometer range to below 100 nm site sizes [11], [12] as well as simulation studies of various kinds that are not focused on quantities that are directly measurable. In this paper we use the term nanodosimetry for studies of charged particle track structure, considering the stochastics of ionizations in nanometric targets.The quantity of interest is the relative frequency distribution of the so-called ionization cluster size, i.e. the number of ionizations inside a considered target (often called the 'site'). As is illustrated in Figure 1, the ionization cluster size distribution (ICSD) varies with the geometrical position of the target with respect to the particle track. Furthermore, it also depends on the size and composition of the target and, most importantly, on the radiation quality. The ICSD can also be characterized by its statistical moments or the complementary cumulative frequencies of ionization clusters exceeding a certain minimum size [13].Around the turn of the century, three different types of nanodosimeters have been developed to measure the frequency distribution of ionization cluster size [14]. All devices are gas counters that simulate nanometric sensitive volumes based on a density scaling principle [15]. They Figure 1. Schematic illustration of nanodosimetric ionization cluster size (ICS) distributions in a spread-out Bragg peak (SOBP) of protons in water. The orange spheres indicate the loci of ionizing interactions of the proton or of the emitted secondary electrons. The blue and red cylinders represent nanometric targets located in the core and in the penumbra region of the track, respectively. The histograms with the blue and red...

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confidence: 99%

Nanodosimetry – on the ''tracks'' of biological radiation effectiveness

Rabus¹

2020

Zeitschrift für Medizinische Physik

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“…Develop density scaling relationships for micro- and nano-dosimetry ( 19 , 20 ) using theoretical and simulation studies as well as the characterisation of existing ( 21 ) and emerging nanodosimetric detectors ( 22–24 ) .…”

Section: Vision 1: Towards Updated Fundamental Dose Concepts and Quantitiesmentioning

confidence: 99%

“…Identify biologically relevant target sizes from a comprehensive characterisation of track structure; develop track structure imaging techniques ( 25 , 26 ) , complemented by experimental investigations of radiation interactions in condensed phase nanometric objects ( 22 , 27 , 28 ) .…”

Section: Vision 1: Towards Updated Fundamental Dose Concepts and Quantitiesmentioning

confidence: 99%

Eurados Strategic Research Agenda 2020: Vision for the Dosimetry of Ionising Radiation

Harrison

Ainsbury

Alves

et al. 2021

Radiation Protection Dosimetry

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Since 2012, the European Radiation Dosimetry Group (EURADOS) has developed its Strategic Research Agenda (SRA), which contributes to the identification of future research needs in radiation dosimetry in Europe. Continued scientific developments in this field necessitate regular updates and, consequently, this paper summarises the latest revision of the SRA, with input regarding the state of the art and vision for the future contributed by EURADOS Working Groups and through a stakeholder workshop. Five visions define key issues in dosimetry research that are considered important over at least the next decade. They include scientific objectives and developments in (i) updated fundamental dose concepts and quantities, (ii) improved radiation risk estimates deduced from epidemiological cohorts, (iii) efficient dose assessment for radiological emergencies, (iv) integrated personalised dosimetry in medical applications and (v) improved radiation protection of workers and the public. This SRA will be used as a guideline for future activities of EURADOS Working Groups but can also be used as guidance for research in radiation dosimetry by the wider community. It will also be used as input for a general European research roadmap for radiation protection, following similar previous contributions to the European Joint Programme for the Integration of Radiation Protection Research, under the Horizon 2020 programme (CONCERT). The full version of the SRA is available as a EURADOS report (www.eurados.org).

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“…Papers [14][15][16][17] are devoted to the analysis of the structural changes and damage of biological objects exposed to ionizing radiation.…”

Section: Radiobiological Effectsmentioning

confidence: 99%

“…In reference [17] the authors investigate the impact of radiation-induced damages on the change the electrical impedance of a DNA molecule. The damage due to ionising radiation is shown to have a direct effect on the electrical transport properties of DNA.…”

Section: Radiobiological Effectsmentioning

confidence: 99%