Cardiac output (CO) can be determined using pulmonary artery catheters and thermodilution techniques. The purpose of this paper is to describe the thermodilution principle and to consider factors and pathology which may invalidate the CO determination.
Thermodilution techniqueThe injection of a known amount of indicator (a cool solution) into the right atrium through the proximal port of a pulmonary artery catheter (PAC) is detected distally by a thermistor located 4 cm from the end of the PAC. ~ The change in temperature of blood in pulmonary artery causes a change in the thermistor Wheatstone bridge resistance which allows a computer to calculate the area under the thermodilution curve (Figure (a)). This and the volume of injectate allow computation of CO. 2 The shape of the thermodilution curve is similar to dye dilution curves except thermodilution recirculation is small (about four per cent of the peak of the curve). 3 The thermodilution curve peaks rapidly and then follows an exponential decay, until there is recirculation or delayed cooling from the residual indicator in the PAC. 4 This last portion of the curve should not be used in determining the area under the curve.Cardiac output is determined from the following equation 2 CO = Vt (TB --Ti)KtK2/ATB(t)dt where Vj is the injectate volume, TB is the blood From the