Measurement of Bone Mineral in vivo: An Improved Method

Cameron, John; Sorenson, James A.

doi:10.1126/science.142.3589.230

Cited by 739 publications

(111 citation statements)

References 5 publications

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“…If the calcium balance is zero, CaA -Cauv should be equal to the net secreted Ca. The bone density was determined from the absorption of 'I photon by bone with Norland-Cameron bone mineral analyzer (14). It was expressed as the ratio of bone mineral content and bone width in grams per square centimeter.…”

Section: Clinical Datamentioning

confidence: 99%

The Hypercalciurias CAUSES, PARATHYROID FUNCTIONS, AND DIAGNOSTIC CRITERIA

Pak¹,

Oata²,

Lawrence³

et al. 1974

J. Clin. Invest.

495

137

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A B S T R A C T The causes for the hypercalciuria and diagnostic criteria for the various forms of hypercalciuria were sought in 56 patients with hypercalcemia or nephrolithiasis (Ca stones), by a careful assessment of parathyroid function and calcium metabolism. A study protocol for the evaluation of hypercalciuria, based on a constant liquid synthetic diet, was developed. In 26 cases of primary hyperparathyroidism, characteristic features were: hypercalcemia, high urinary cyclic AMP (cAMP, 8.58+3.63 SD gmol/g creatinine; normal, 4.02±0.70 umol/g creatinine), high immunoreactive serum parathyroid hormone (PTH), hypercalciuria, the urinary Ca exceeding absorbed Ca from intestinal tract (CaA), high fasting urinary Ca (0.2 mg/mg creatinine or greater), and low bone density by 'I photon absorption. The results suggest that hypercalciuria is partly secondary to an excessive skeletal resorption (resorptive hypercalciuria). The 22 cases with renal stones had normocalcemia, hypercalciuria, intestinal hyperabsorption of calcium, normal or low serum PTH and urinary cAMP, normal fasting urinary Ca, and normal bone density. Since their CaA exceeded urinary Ca, the hypercalciuria probably resulted from an intestinal hyperabsorption of Ca (absorptive hypercalciuria). The primacy of intestinal Ca hyperabsorption was confirmed by responses to Ca load and deprivation under a metabolic dietary regimen. During a Ca load of 1,700 mg/day, there was an exaggerated increase in the renal excretion.of Ca and a suppression of cAMP excretion. The urinary Ca of 453±+154 SD mg/day was significantly higher than the control group's 211+42 mg/ day. The urinary cAMP of 2.26±0.56 umol/g creatinine was significantly lower than in the control group. In contrast, when the intestinal absorption of calcium was limited by cellulose phosphate, the hvpercalciuria was kc'ceiz(l for plblicatifn 9 July 1073 and in rezxsed form 11 September 1973. corrected and the suppressed renal excretion of cAMP returned towards normal. Two cases with renal stones had normocalcemia, hypercalciuria, and high urinary cAMP or serum PTH. Since CaA was less than urinary Ca, the hypercalciuria may have been secondary to an impaired renal tubular reabsorption of Ca (renal hypercalciuria). Six cases with renal stones had normal values of serum Ca, urinary Ca, urinary cAMP, and serum PTH (normocalciuric nephrolithiasis). Their CaA exceeded urinal Ca, and fasting urinary Ca and bone density were normal. The results support the proposed mechanisms for the hypercalciuria and provide reliable diagnostic criteria for the various forms of hypercalciuria.

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Section: Clinical Datamentioning

confidence: 99%

The Hypercalciurias CAUSES, PARATHYROID FUNCTIONS, AND DIAGNOSTIC CRITERIA

Pak¹,

Oata²,

Lawrence³

et al. 1974

J. Clin. Invest.

495

137

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show abstract

“…Some 10 years ago the technique of scanning using an isotope point source was introduced by Cameron and Sorenson (1963) and over the intervening decade this method has been further improved (Sorenson and Cameron, 1967). They claim a 2 per cent.…”

Section: Introductionmentioning

confidence: 99%

The use of photon densitometry to evaluate bone mineral in a group of patients with spinal gord injury

Griffiths

Zimmerman²

1973

Spinal Cord

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“…Many of the pioneers of nuclear medicine, including Mayneord, [45][46][47] Anger,48,49 Cameron and Sorenson, 50 and Kuhl 51 recognized that a radionuclide imaging system could be augmented by adding an external radioisotope source to acquire transmission data for anatomical correlation of the emission image. Furthermore, Kuhl et al 52 added an external radionuclide source on his Mark IV brain scanner to produce anatomical images useful for both localizing regions of radionuclide uptake and to correct for soft tissue absorption in the radionuclide emission data.…”

Section: Brief History Of Dual-modality Imagingmentioning

confidence: 99%