Measurement of blood phosphorus: A quick and inexpensive method for detection of the existence of cancer in the body. Too good to be true, or forgotten knowledge of the past?

Papaloucas, Christos; Papaloucas, Marios; Kouloulias, Vassilis; Neanidis, K.; Pistevou-Gompaki, Kyriaki; Kouvaris, John; Zygogianni, Anna; Mystakidou, K.; Papaloucas, Aristofanis

doi:10.1016/j.mehy.2013.10.028

Cited by 25 publications

(24 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…supported by further observations313233. Recently, Papaloucas et al 34. reported significantly higher P content in the serum of a group of cancer patients measured before the commencement of any treatment (12 head and neck, 13 cervical and 25 non-small cell lung cancer cases) compared to a group of 50 healthy individuals.…”

Section: Discussionmentioning

confidence: 61%

“…reported significantly higher P content in the serum of a group of cancer patients measured before the commencement of any treatment (12 head and neck, 13 cervical and 25 non-small cell lung cancer cases) compared to a group of 50 healthy individuals. Unfortunately, there is a current uncertainty in whether the increased P content in the serum observed in these cancer patients34 and elevated interstitial Pi content observed in various mouse model tumors in our work is causal.…”

Section: Discussionmentioning

confidence: 79%

“…Thus, oncological hypophosphatemia has been proposed to reflect transfer of serum Pi into proliferating malignant cells36. The authors34 consider that increased amount of phosphorus in the blood, when excluding other causes justifying such an increase, may indicate the existence of unidentified cancerous lesions, therefore providing a quick and inexpensive method for detection of an emergence of cancer in the body. In our opinion, measurement of interstitial [Pi] might be more sensitive and specific to cancer compared to blood measurements allowing for localized [Pi] measurements in tumor tissue.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Interstitial Inorganic Phosphate as a Tumor Microenvironment Marker for Tumor Progression

Bobko

Eubank

Driesschaert

et al. 2017

Sci Rep

104

View full text Add to dashboard Cite

Noninvasive in vivo assessment of chemical tumor microenvironment (TME) parameters such as oxygen (pO2), extracellular acidosis (pHe), and concentration of interstitial inorganic phosphate (Pi) may provide unique insights into biological processes in solid tumors. In this work, we employ a recently developed multifunctional trityl paramagnetic probe and electron paramagnetic resonance (EPR) technique for in vivo concurrent assessment of these TME parameters in various mouse models of cancer. While the data support the existence of hypoxic and acidic regions in TME, the most dramatic differences, about 2-fold higher concentrations in tumors vs. normal tissues, were observed for interstitial Pi - the only parameter that also allowed for discrimination between non-metastatic and highly metastatic tumors. Correlation analysis between [Pi], pO2, pHe and tumor volumes reveal an association of high [Pi] with changes in tumor metabolism and supports different mechanisms of protons and Pi accumulation in TME. Our data identifies interstitial inorganic phosphate as a new TME marker for tumor progression. Pi association with tumor metabolism, buffer-mediated proton transport, and a requirement of high phosphorus content for the rapid growth in the “growth rate hypothesis” may underline its potential role in tumorigenesis and tumor progression.

show abstract

Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Interstitial Inorganic Phosphate as a Tumor Microenvironment Marker for Tumor Progression

Bobko

Eubank

Driesschaert

et al. 2017

Sci Rep

104

View full text Add to dashboard Cite

show abstract

“…A separate study found no association between dietary zinc and the risk of cervical disease [17] , although a subsequent investigation found that dietary zinc reduced the risk of CIN [18] , while low intake of zinc was a risk factor for cervical cancer [19] . Furthermore, dietary phosphorus was found to be significantly associated with cancer development [20] . Although there is no reported direct association between dietary phosphorus and cervical cancer [18] , a significant association was found between the dietary calcium-to-phosphorus ratio and the risk of CIN [15] .…”

Section: Ivyspringmentioning

confidence: 99%

Lower dietary mineral intake is significantly associated with cervical cancer risk in a population-based cross-sectional study

Wang

Yang

et al. 2021

J. Cancer

View full text Add to dashboard Cite

Population-based studies investigating the association between dietary mineral intake and risk of cervical intraepithelial neoplasia (CIN) or cervical cancer in Chinese women are few. We performed a cross-sectional analysis of screening data obtained from 2,304 women in 2014 within an ongoing cohort study comprising 40,000 women in China. Dietary intake was assessed using a semiquantitative food frequency questionnaire. Nutrition intake was calculated using a 26-item list of food sources drawn from a validated, comprehensive database. All participants were surveyed through in-person interviews, physical examinations, and laboratory tests. The Pearson chi-square test was used for categorical variables. Multivariable logistic regression models were used to evaluate the relationship between dietary mineral intake and CIN+ risk. The food frequency questionnaire exhibited acceptable reproducibility and reasonable validity in assessing nutrient intakes among these women. After adjusting for multiple potential confounders, low dietary calcium intake was associated with CIN2+ risk (first versus fourth quartile: odds ratio [OR]=1.52, 95% confidence interval [CI]: 1.01-2.32). Similar for magnesium (OR=1.80, 95% CI: 1.20-2.68), phosphorus (OR=1.69, 95% CI: 1.12-2.55), zinc (OR=1.55, 95% CI: 1.03-2.34), and potassium (OR=1.92, 95% CI: 1.28-2.88). Low dietary intakes of calcium and potassium were significantly associated with CIN1 risk. Increased CIN2+ risk correlated with rates of no oral contraceptives and lower levels of dietary Potassium. These results thus proposed that low dietary mineral intake was an independent risk factor, potential synergy may exist between low dietary mineral levels and oral contraceptives contribute to the development of higher-grade CIN and cervical cancer.

show abstract

“…While serum phosphorus levels are not always a reliable indicator of phosphate stored in the body, a study of cancer patients found that they had abnormally higher serum phosphate levels compared to control patients [33]. The Health Professionals Follow-Up Study found that high-grade prostate cancer was associated with high dietary phosphate levels [34].…”

Section: Dysregulated Phosphate Metabolism and Cancermentioning

confidence: 99%

Dysregulated Phosphate Metabolism, Periodontal Disease, and Cancer: Possible Global Health Implications

Brown

2019

Dentistry Journal

View full text Add to dashboard Cite

An association between periodontal disease and cancer has been established in recent studies, but no common etiology has been identified in the hopes of reducing the global burden of these non-communicable diseases. This perspective article hypothesizes that the determinant mediating the association of periodontal disease with cancer is dysregulated phosphate metabolism. Phosphate, an essential dietary micronutrient, is dysregulated in chronic kidney disease, and both cancer and periodontal disease are associated with chronic kidney disease. Reviewed evidence includes the association between phosphate toxicity and cancer development, and the association between periodontal disease and chronic kidney disease-mineral and bone disorder includes conditions such as ectopic calcification and bone resorption, which may be indirectly related to periodontal disease. Dental calculus in periodontal disease contains calcium phosphate crystals that are deposited from excess calcium and phosphate in saliva. Alveolar bone resorption may be linked systemically to release of parathyroid hormone in response to hypocalcemia induced by hyperphosphatemia. More research is needed to examine the role of dysregulated phosphate metabolism in periodontal disease.

show abstract

Measurement of blood phosphorus: A quick and inexpensive method for detection of the existence of cancer in the body. Too good to be true, or forgotten knowledge of the past?

Cited by 25 publications

References 9 publications

Interstitial Inorganic Phosphate as a Tumor Microenvironment Marker for Tumor Progression

Interstitial Inorganic Phosphate as a Tumor Microenvironment Marker for Tumor Progression

Lower dietary mineral intake is significantly associated with cervical cancer risk in a population-based cross-sectional study

Dysregulated Phosphate Metabolism, Periodontal Disease, and Cancer: Possible Global Health Implications

Contact Info

Product

Resources

About