Measurement of Blood Flow in Human Myometrium by Local Hydrogen Clearance

Klingenberg, I

doi:10.3109/00016346909156662

Cited by 16 publications

(3 citation statements)

References 3 publications

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“…The uterus has a rich blood supply, and so drug efficacy may appear very fast. The blood flow of the uterus is 64.2 mL/min/100g , while that of the small intestine is 38 mL/min/100g , which is less than that of the uterus. Although the above data for uterine perfusion is not specified as being derived from either the inner or outer myometrium, the inner myometrium is supposed to have richer perfusion compared with the outer myometrium in women of reproductive age .…”

Section: Discussionmentioning

confidence: 83%

Anticholinergic agents result in weaker and shorter suppression of uterine contractility compared with intestinal motion: time course observation with cine MRI

Daido

Nakai

Kido

et al. 2013

Magnetic Resonance Imaging

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Section: Discussionmentioning

confidence: 83%

Anticholinergic agents result in weaker and shorter suppression of uterine contractility compared with intestinal motion: time course observation with cine MRI

Daido

Nakai

Kido

et al. 2013

Magnetic Resonance Imaging

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“…It is worth noting that 3D power Doppler US measurements (32) on the same set of volunteers also showed the same variations as the xenon‐133 clearance report. Perfusion measurements have previously been made in the myometrium (33, 34), however the techniques used were invasive and hence the studies did not make repeated measurements throughout the normal menstrual cycle, concentrating on single measurements in patients with gynecological problems (34). Average values measured from these studies, similar to endometrial perfusion values, were 23 mL/100 g/minute (33) (limited measurements in the follicular phase of the normal menstrual cycle) and 64 mL/100 g/minute (34) (patient study group with wide range of gynecological problems).…”

Section: Discussionmentioning

confidence: 99%

In vivo perfusion, T₁, and T₂ measurements in the female pelvis during the normal menstrual cycle: A feasibility study

Hoad

Fulford

Raine‐Fenning

et al. 2006

Magnetic Resonance Imaging

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Purpose: To quantify T 1 , T 2 , and regional tissue perfusion in uterine tissues, with MR imaging in clinically feasible imaging times, using echo planar imaging (EPI) techniques over a single menstrual cycle. Materials and Methods:A total of 24 healthy ovulating women were scanned; however, complete data sets through the menstrual cycle were not obtained from all women. Three scans were performed to coincide prospectively with the follicular, periovulatory, and luteal phases of the cycle. T 1 and perfusion were measured simultaneously using flow alternating inversion recovery (FAIR), while T 2 was measured using a single Hahn spin-echo (SE) EPI sequence. Results:Between the follicular and periovulatory phases, statistically significant increases (P Ͻ 0.05) were seen for the T 2 of the endometrium and perfusion of the myometrium as well as the T 2 /T 1 ratio for both endometrium and myometrium. A statistically significant decrease was seen in the endometrial T 2 between the periovulatory and luteal phases of the cycle. Tissue differentiation was achieved using the parameters measured, with T 1 and T 2 being statistically greater for the endometrium than for the myometrium, and endometrial perfusion being statistically lower than myometrial perfusion. Conclusion:These results show the feasibility of using these techniques to measure T 1 , T 2 , and perfusion in uterine tissues and of extending this work to study pathological conditions.

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“…Таким образом, уровень микроциркуляции оценивается при использовании локальной генерации водорода, тогда как снабжение органа или ткани артериальной кровью -при ингаляции водорода [13,14]. Регистрация локального и регионарного кровотоков с помощью метода водородного клиренса осуществлялся как в эксперименте, так и в клинических условиях у людей с патологиями матки [15], инсультом [16] и другими [17]. Незамеченным, но крайне важным замечанием J.S.…”

Section: водород для диагностических целейunclassified

Current views on the functional role of hydrogen and its kinetics in the human body

Medvedev

2024

Pulʹmonologiâ (Mosk.)

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The purpose of this overview was to present historical data on the discovery of hydrogen and a brief summary of its physical properties that form the basis for its use in aeronautics. Information is provided on the use of hydrogen, a biologically neutral molecule, in medicine as a diagnostic indicator for penetrating wounds of the gastrointestinal tract, the determination of local blood flow using the hydrogen clearance method, the use of the hydrogen breath test for the diagnosis of malabsorption and carbohydrate intolerance, achlorhydria, the diagnosis of bacterial overgrowth syndrome, the assessment of biodegradation of magnesium-containing implants, the orocecal transit time, and during deep-sea diving. The reasons for the sharp increase in the doctors’ interest in studying the biological role of hydrogen after the discovery of its antioxidant properties by a group of Japanese scientists (2007) are analyzed. In order to increase antioxidant protection of the body, data from recent research on ways to increase its concentration in the body through the supply of exogenous gas by inhalation or by administering hydrogen-rich water or saline solution is presented. Particular attention is paid to a critical analysis of studies on the kinetics of hydrogen by different routes, its concentration in blood and tissues, inhalation, and the use of hydrogen-rich water. Based on an analysis of publications, that the use of molecular hydrogen to relieve oxidative stress in the tissues of the intestines, liver and lungs is most promising, since its highest concentration is found in these tissues. Fermentation of carbohydrates has also been shown to increase the production of hydrogen by the intestinal microbiota. Considering that a large number of molecular hydrogen generators appeared on the market, the data on the requirements for their safety are summarized. Considerations on the use of molecular hydrogen for the purpose of antioxidant protection of the body in cardiology, gastroenterology, pulmonology, and other areas of medicine are based on modern views on the mechanisms of antioxidant, anti-apoptotic, cytoprotective, and anti-inflammatory effects of hydrogen. Particular attention is paid to the analysis of experimental and clinical research on the use of hydrogen in acute and chronic lung lesions, therapy of acute and chronic COVID-19 infection.Conclusion. Based on an analysis of the literature and our own data, a conclusion was drawn on the safety and prospects of the clinical use of molecular hydrogen in a wide range of concentrations in many diseases with the pathogenesis based on oxidative stress. In particular, the need for additional research was highlighted to clarify the regimen, frequency, duration and concentrations of hydrogen used, and a personalized approach to the combination of endogenous (from the intestinal microbiota) and exogenous hydrogen in various diseases.

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Measurement of Blood Flow in Human Myometrium by Local Hydrogen Clearance

Cited by 16 publications

References 3 publications

Anticholinergic agents result in weaker and shorter suppression of uterine contractility compared with intestinal motion: time course observation with cine MRI

Anticholinergic agents result in weaker and shorter suppression of uterine contractility compared with intestinal motion: time course observation with cine MRI

In vivo perfusion, T₁, and T₂ measurements in the female pelvis during the normal menstrual cycle: A feasibility study

Current views on the functional role of hydrogen and its kinetics in the human body

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Measurement of Blood Flow in Human Myometrium by Local Hydrogen Clearance

Cited by 16 publications

References 3 publications

Anticholinergic agents result in weaker and shorter suppression of uterine contractility compared with intestinal motion: time course observation with cine MRI

Anticholinergic agents result in weaker and shorter suppression of uterine contractility compared with intestinal motion: time course observation with cine MRI

In vivo perfusion, T1, and T2 measurements in the female pelvis during the normal menstrual cycle: A feasibility study

Current views on the functional role of hydrogen and its kinetics in the human body

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In vivo perfusion, T₁, and T₂ measurements in the female pelvis during the normal menstrual cycle: A feasibility study