Measurement of an optical anisotropy of biotissues

Simonenko, Georgy V.; Denisova, Tatyana P.; Lakodina, Nina A.; Tuchin, Valery V.

doi:10.1117/12.384167

Cited by 6 publications

(8 citation statements)

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“…33. A tissue layer works as a phase plate (or number of phase plates), [296][297][298] whose linear birefringence is spatially and temporally dependent. As scattering goes down with time due to RI matching, the birefringence of fibrillar structure of the sclera affects the transmittance of the optical system in crossed polarizers (see also Fig.…”

Section: Polarization-sensitive Optical Coherence Tomographymentioning

confidence: 99%

Polarized light interaction with tissues

2016

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This tutorial-review introduces the fundamentals of polarized light interaction with biological tissues and presents some of the recent key polarization optical methods that have made possible the quantitative studies essential for biomedical diagnostics. Tissue structures and the corresponding models showing linear and circular birefringence, dichroism, and chirality are analyzed. As the basis for a quantitative description of the interaction of polarized light with tissues, the theory of polarization transfer in a random medium is used. This theory employs the modified transfer equation for Stokes parameters to predict the polarization properties of single- and multiple-scattered optical fields. The near-order of scatterers in tissues is accounted for to provide an adequate description of tissue polarization properties. Biomedical diagnostic techniques based on polarized light detection, including polarization imaging and spectroscopy, amplitude and intensity light scattering matrix measurements, and polarization-sensitive optical coherence tomography are described. Examples of biomedical applications of these techniques for early diagnostics of cataracts, detection of precancer, and prediction of skin disease are presented. The substantial reduction of light scattering multiplicity at tissue optical clearing that leads to a lesser influence of scattering on the measured intrinsic polarization properties of the tissue and allows for more precise quantification of these properties is demonstrated.

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Section: Polarization-sensitive Optical Coherence Tomographymentioning

confidence: 99%

Polarized light interaction with tissues

2016

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“…1 was used. 13,14,18 In the study samples of the following tissues were used: cartilage of knee articular surface, meniscus and nasal septum, sclera, and tunica testis. To clarify optically a tissue sample via reduction of its scattering coefficient we have used 60%-trazograph solution (Xray contrasting drug for intravenous applications).…”

Section: Methodsmentioning

confidence: 99%

“…22,23 The early studies of polarization properties of sclera, cornea, cartilage, bloodless muscular tissue at optical clearing showed that optical properties of these tissue look like optical properties of uni-axial or bi-axial crystals. 13,14,18 In this paper the study of optical clearing dynamics of various connective tissues was carried out by means of polarization microscopy. Difference in the rate of optical clearing of such tissues as cartilage, meniscus, nasal septum tissues, sclera and tunica testis was found.…”

Section: Introductionmentioning

confidence: 99%

“…[2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] Optical clearing is a very promising technique for monitoring of drugs and metabolic liquids diffusion within a tissue. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] In particular, glucose monitoring in the human skin was provided using refractive index matching ideology. 22,23 The early studies of polarization properties of sclera, cornea, cartilage, bloodless muscular tissue at optical clearing showed that optical properties of these tissue look like optical properties of uni-axial or bi-axial crystals.…”

Section: Introductionmentioning

confidence: 99%

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